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Basic Research Faculty

  • Michael A. Brehm

    Michael A. Brehm, PhD

    Associate Professor, Program in Molecular Medicine, Robert and Sandra Glass Term Chair in Diabetes

    Interests: Understanding the immune mechanisms that regulate the development of human autoimmune disease.  We've developed unique "humanized" mouse models of human immune responses, allowing us to investigate approaches to downregulate as well as activate the human immune system for the treatment of type 1 diabetes as well as potential cancer treatment.

    Brehm Lab      

  • Silvia Corvera

    Silvia Corvera, MD

    Professor, Program in Molecular Medicine, Chair in Diabetes Research, Director, MSTP (MD-PhD) Program

    Interests: Understanding the basic physiopathology of type 2 diabetes, specifically the role of adipose tissue physiology in diabetes pathogenesis. 

    Corvera Lab   

  • Michael P. Czech

    Michael P. Czech, PhD

    Professor, Program in Molecular Medicine, Isadore and Fannie Foxman Chair of Medical Research

    Interests: Our laboratory is dedicated to the discovery of molecular mechanisms whereby insulin signaling regulates energy homeostasis.  This includes RNAi screens, digital imaging and TIRF microscopy, phenotyping mice with gene knockouts and analysis of human adipose tissues.  We hope to translate our findings to the prevention and treatment of type 2 diabetes.

    Czech Lab    

  • Roger J. Davis

    Roger J. Davis, PhD, FRS

    Professor and Chair, Program in Molecular Medicine, Howard Hughes Medical Institute Investigator, Fellow of the Royal Society, Member of the National Academy of Sciences , H. Arthur Smith Chair in Biomedical Research

    Interests: The molecular mechanism by which inflammation contributes to diabetes, cancer and stroke.  Our studies of stress signaling pathways have led to the discovery of new genes that contribute to the development of diabetes and other diseases. 

    Davis Lab     

  • Dale L. Greiner

    Dale L. Greiner, PhD

    Professor, Program in Molecular Medicine, Co-director, Diabetes Center of Excellence, Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research

    Interests: Human immune responses, both how to turn them off for the treatment of type 1 diabetes and autoimmunity and conversely, to use the same pathways to turn the immune response on for the treatment of cancer.  We utilize our unique animal models of human immune responses for investigating these approaches to downregulate as well as activate the human immune system.

    Greiner Lab      

  • David A. Guertin

    David A. Guertin, PhD

    Associate Professor, Program in Molecular Medicine

    Interests: Understanding how insulin resistance develops, especially in obesity and lipodystrophy.  Identifying therapeutic strategies to improve how the body processes blood sugar (glucose). Exploring the biochemical mechanisms controlling cell growth and metabolism and their significance to the pathogenesis of metabolic diseases including type 2 diabetes.

    Guertin Lab    

  • David M. Harlan

    David M. Harlan, MD

    Professor, Department of Medicine, Chief, Diabetes Division, Co-director, Diabetes Center of Excellence, William and Doris Krupp Chair in Diabetes

    Interests: Exploring beta cell biology and the anti-beta cell immune response underlying type 1 diabetes.  We've developed innovative techniques to sort human pancreatic islet endocrine cell subsets, including from donors with both type 1 and type 2 diabetes, to determine the transcriptome from those purified cells.  We're also working to develop better diabetes care delivery models.

    Harlan Lab         Clinical Profile                

  • Sally C. Kent

    Sally C. Kent, PhD

    Associate Professor, Department of Medicine

    Interests: Autoimmune response in human type 1 diabetes.  In particular, T cell responses to self-proteins.  We want to understand how and why these immune cells are attacking the insulin producing beta cells in people with T1D.

    Kent Lab       

  • Jason K. Kim

    Jason K. Kim, PhD

    Professor, Program in Molecular Medicine, Director, UMass Mouse Metabolic Phenotyping Center

    Interests: Our research investigates obesity, diabetes and its complications.  The goal of our research is to understand how obesity causes diabetes and to find its cure.

    Kim Lab   

  • Hardy Kornfeld

    Hardy Kornfeld, MD

    Professor, Department of Medicine

    Interests: The impact of diabetes and hyperlipidemia on Tuberculosis defense

    Kornfeld Lab     UMass Profile

  • Yunsheng Ma

    Yunsheng Ma, MD, PhD, MPH

    Associate Professor, Department of Medicine

    Interests: Prevention and treatment of type 2 diabetes, as well as racial/ethnic disparities in the prevalence, incidence, treatment, medical and survival outcomes among diabetic patients.

    UMass Profile

  • René Maehr

    René Maehr, PhD

    Associate Professor, Program in Molecular Medicine, Glass Charitable Foundation Term Chair in Diabetes

    Interests: The molecular pathways that govern thymus organogenesis and function, and to translate this knowledge to stem cell approaches to recapitulate and investigate human immune syndromes associated with this organ, including type 1 diabetes.

    Maehr Lab     

  • Louis M. Messina

    Louis M. Messina, MD

    Professor and Vice Chair, Department of Surgery, Johnnie Ray Cox Term Chair in Biomedical Research

    Interests: Investigating new hematopoietic stem cell–based therapeutic approaches to treat type 2 diabetes and other common diseases. Determining the effects of T2D on wound healing and identifying the molecular and cellular mechanisms that could lead to potential therapies. 

    Messina Lab          UMass Profile

  • John P. Mordes

    John P. Mordes, MD

    Professor, Department of Medicine

    Interests: Basic and clinical research in the area of type 1 diabetes.

    Clinical Profile

  • Jennifer P. Wang

    Jennifer P. Wang, MD

    Associate Professor, Department of Medicine

    Interests: How innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes 

    Wang Lab       Clinical Profile   

  • Yong-Xu Wang

    Yong-Xu Wang, PhD

    Associate Professor, Program in Molecular Medicine

    Interests: Brown fat development and browning of white fat.  We particularly focus on transcriptional control, epigenetics, non-coding RNAs, and signaling molecules.

    Wang Lab       

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