Michael A. Brehm, PhD
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Associate Director, Diabetes Center of Excellence
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Professor of Molecular Medicine, The Harvey A. Shultz Chair in Diabetes
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Co-Director, UMass Chan Humanized Mouse Core
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Investigator, Breakthrough T1D (formerly JDRF) Center of Excellence in New England
Dr. Brehm specializes in novel preclinical models that simulate human immune responses to investigate approaches for downregulating and activating the human immune system in the treatment of type 1 diabetes (T1D) and cancer. His laboratory examines human beta cells from individuals with T1D in vivo as they interact with intact immune systems from those same donors. The ultimate goal is to understand the etiology and pathogenesis of autoimmune T1D to develop new therapies or drugs for personalized medicine.
Meet Dr. Michael Brehm
Researcher Spotlight: Mina Seedhom, PhD
Mina Seedhom, PhD, a Senior Research Scientist, leads our studies reconstructing human type 1 diabetes using stem cell-derived islets inside our novel models to observe the interactions between insulin-producing beta cells and immune cells in vivo. Learn More
Researcher Spotlight: Carey Zammitti
Carey is a Research Associate involved in our humanized mouse model pre-clinical studies, and testing the functionality of microscopic encapsulation devices to protect insulin-producing islets and beta cells from being recognized and attacked by the immune system. Learn More
Brehm Lab outing to Tree House Brewery in Charlton, MA
Dr. Brehm arranged for the Uhlman's ice cream truck to visit on a beautiful summer afternoon to treat the lab for an ice cream break.