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Some of Our Current Research Includes

Specialized Mouse Avatars for Type 1 Diabetes

Reconstructing human type 1 diabetes (T1D), using cells derived from T1D patients, in our novel immunodeficient mouse.  It provides a better understanding about how humans might react to certain factors.

Use of Specialized Mouse Models to Determine the Role of Costimulation Pathway Reagents in Human Immune Cells In Vivo

Assessing the role of human T cell costimulation pathway reagents in vivo using our unique specialized mouse models. 

Development and Validation of Novel Mouse Models for Human Stem Cell Therapy

Working to generate new models of immunodeficient mice for the functional in vivo evaluation of human stem cells and to validate these models by determining the ability of human stem cells to generate functional differentiated human cells and tissues that ameliorate disease.

Graphene Composite Membranes for Nano-Enabled Macroencapsulation

Developing an encapsulation device using graphene composite membranes in collaboration with Lockheed Martin to assess the viability and function of encapsulated human islets in vivo. 

From New Models to Novel Therapeutics

Co-director with Dale Greiner, PhD, of a pre-clinical/co-clinical core to advance development and use of models of human specific diseases.  The Core is working with The Jackson Laboratory (JAX) Precision Genetics Center (JPGC) promoting interactions with clinicians and hospitals, access to patient data and samples and comprehensive model assessment necessary for generation of models engrafted with human tumors and immune systems for preclinical testing.

Dale Greiner & Michael Brehm with Leonard Schultz of The Jackson Laboratory