Congratulations to our colleague Roger Davis on his election to the National Academy of Sciences!

 

 

 

 


 

In-House Seminar Series 

Paul Greer, Ph.D.
Assistant Professor, PMM

“Detecting interoceptive and exteroceptive chemical signals with MS4A receptors”

Monday, May 7, 2018 @12:00 pm

Molecular Medicine Seminar Room
3rd Floor, Biotech Two


       Save the date

Thursday, November 15, 2018 @ 4:00pm

Pioneers in Molecular Medicine

Peter Walter, Ph.D.
Professor and Chair, Department of Biochemistry/Biophysics, UCSF; Investigator, Howard Hughes Medical Institute

 


 

Chair's Message

In-House Seminar Series

CONFABS

Retreats
2005 - 2008 - 2012 - 2015

Michael Green Election to the National Academy of Sciences 2014

Nobel Prize Reception

Davis Royal Society Reception

Ambros Lasker Reception

Ambros Silverman Lecture


NEWS


 


Paul Greer - Smelling the Cheese
using the mouse olfactory system to explore how sensory input gets translated into action. (video)

Craig Peterson receives $4.5 million outstanding investigator award
from NIH MIRA program encourages investigators to embark on ‘long-term projects of unusual potential’ (announcement)

 
Chancellor’s Award -
Kasmir Ramo
Jun Kinases in Hematopoiesis and
Vascular Development and Function
Roger Davis, PhD, Mentor (announcement)

Jeremy Luban - UMMS study suggests Ebola virus mutation caused recent outbreak (Video); Ebola Evolved Into Deadlier Enemy During the African Epidemic - The New York Times (Article)

Victor Ambros - Awarded 2016 March of Dimes prize for co-discovery of MicroRNAs (announcement)

Katherine Luzuriaga - Elimination of pediatric HIV

Silvia Corvera - UMMS researchers illuminate origins, benefits of ‘beige fat’

Joel Richter named to newly endowed chair - (Article)

Michael Green elected to National Academy of Medicine - (Article)

UMMS scientists identify genes that shut down HIV-1; research published in Nature - (Article)

Discoveries in Luban, Gottlinger labs point to new strategies for disabling viruses - (Article)

Zhao Zhang receives the 2015 Larry Sandler Memorial Award - (Article)

Jeremy Luban and Manuel Garber receive $6.1 Million over 3 years to
establish one of five Genomics of Gene Regulation Programs - (article) 

Victor Ambros awarded 2015 $3M Breakthrough Prize for co-discovery of microRNAs - (Article)

Joel Richter receives $9.3 million over 5 years to establish one of three national Centers for Collaborative Research in Fragile X - (NIH Article)

Victor Ambros named co-recipient of 2014 Gruber Genetics Prize - (Article)

Heinrich Gottlinger, M.D. recipient of 2014 Avant-Garde Award - (Article)

Michael Green elected to National Academy of Sciences - (Article)

Jeremy Luban elected fellow of the American Academy of Microbiology - (Article)

Victor Ambros named recipient of Israel's 2014 Wolf Prize. - (Article)

Thomas Fazzio named one of the nations top scientists - (Article)

Foreign Policy names Luzuriaga a ‘Leading Global Thinker of 2013’ for HIV research - (Article)

Dekker, Sullivan named fellows of prestigious scientific society
American Association for the Advancement of Science fellows announced - (Article)

Roger Davis wins 2013 Steven C. Beering Award - (Article)

Victor Ambros wins Keio Medical Science Prize - (Article)

Katherine Luzuriaga named one of TIME magazine’s TIME 100 - (Article)

Eduardo Torres Named 2013 Searle Scholar - (Article)

Researchers describe first 'functional HIV cure' in an infant (Article)

Bitter taste receptors in airway cells could help treat asthma attacks - (Article)

Roger Davis elected a Fellow of AAAS - (Article)

 

Recent Molecular Medicine Publications

 Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development.

Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, Pazour GJ. Mech Dev. 2018 Apr 4. pii: S0925-4773(18)30009-1. doi: 10.1016/j.mod.2018.04.001. [Epub ahead of print] PMID: 29626631 [PubMed - as supplied by publisher] (Paper)

Intification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline.

Shen EZ, Chen H, Ozturk AR, Tu S, Shirayama M, Tang W, Ding YH, Dai SY, Weng Z, Mello CC. Cell. 2018 Feb 22;172(5):937-951.e18. doi: 10.1016/j.cell.2018.02.002. Epub 2018 Feb 15. PMID: 29456082 [PubMed - in process].  (Paper)

Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon.

Donnard E, Vangala P, Afik S, McCauley S, Nowosielska A, Kucukural A, Tabak B, Zhu X, Diehl W, McDonel P, Yosef N, Luban J, Garber M.  Cell Syst. 2018 Jan 30. pii: S2405-4712(18)30002-4. doi: 10.1016/j.cels.2018.01.002. [Epub ahead of print].  PMID: 29454939 [PubMed - as supplied by publisher]. (Paper)

Identification and characterization of T reg-like cells in zebrafish.

Melissa Kasheta, Corrie A. Painter, Finola E. Moore, Riadh Lobbardi, Alysia Bryll,  Freiman, David Stachura, Arlin B. Rogers, Yariv Houvras, David M. Langenau, Craig J. Ceol .  J Exp Med. 2017 Dec 4;214(12):3519-3530. doi: 10.1084/jem.20162084. Epub 2017 Oct 24. PMID:29066577 PMCID: PMC5716030 [Available on 2018-06-04] DOI: 10.1084/jem.20162084.  (Paper)

Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.

Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG. Structure. 2017 Dec 16. pii: S0969-2126(17)30393-3. doi: 10.1016/j.str.2017.11.019.  PMID: 29276036. PMC5752578.  (Paper)

JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins.

Girnius N, Davis RJ. Cell Rep. 2017 Nov 14;21(7):1910-1921. doi: 10.1016/j.celrep.2017.10.067. PMID: 29141222.  PMCID:  PMC5711519. (Paper)

Using an Inducible CRISPR-dCas9-KRAB Effector System to Dissect Transcriptional Regulation in Human Embryonic Stem Cells.

Parsi KM, Hennessy E, Kearns N, Maehr R.  Methods Mol Biol. 2017;1507:221-233.  PMID:  27832534. DOI: 10.1007/978-1-4939-6518-2_16  (Paper)

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.

Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA. Cell Metab. 2017 Nov 15. pii: S1550-4131(17)30620-4. PMID: 29153407 PMCID: PMC5762420 [Available on 2019-01-09] DOI: 10.1016/j.cmet.2017.10.008   (Paper)

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation.

Huang L, Pan D, Chen Q, Zhu LJ, Ou J, Wabitsch M, Wang YX.  Nat Commun. 2017 Jul 12;8(1):68. doi: 10.1038/s41467-017-00098-2. PMID: 28701693  (Paper)

A microRNA family exerts maternal control on sex determination in C. elegans.

McJunkin K, Ambros V.   Genes Dev. 2017 Feb 15;31(4):422-437. doi: 10.1101/gad.290155.116. Epub 2017 Mar 9.  PMID:28279983.  PMCID:PMC5358761.  (Paper) 

Visualization of self-delivering hydrophobically modified siRNA cellular internalization.

Ly S, Navaroli DM, Didiot MC, Cardia J, Pandarinathan L, Alterman JF, Fogarty K, Standley C, Lifshitz LM, Bellve KD, Prot M, Echeverria D, Corvera S, Khvorova A. Nucleic Acids Res. 2016 Nov 28. pii: gkw1005. [Epub ahead of print].  PMID: 27899655.  (Paper)

Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations.

Duenas-Decamp M, Jiang L, Bolon D, Clapham PR.  PLoS Pathog. 2016 Nov 7;12(11):e1005988. doi: 10.1371/journal.ppat.1005988. eCollection 2016.  PMID: 27820858 (Paper)

Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler

Echtenkamp FJ, Gvozdenov Z, Adkins NL, Zhang Y, Lynch-Day M, Watanabe S, Peterson, CL, Freeman BC.  Mol Cell. 2016 Dec 1;64(5):888-899. doi: 10.1016/j.molcel.2016.09.040. Epub 2016 Nov 3.  PMID:27818141.  DOI:10.1016/j.molcel.2016.09.040 (Paper)

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.

DiStefano MT, Roth Flach RJ, Senol-Cosar O, Danai LV, Virbasius JV, Nicoloro SM, Straubhaar J, Dagdeviren S, Wabitsch M, Gupta OT, Kim JK, Czech MP.   Mol Metab. 2016 Sep 28;5(12):1149-1161.  PMID: 27900258.  (Paper) 

High EBV load and genomic diversity are associated with generation of gp350 specific neutralizing antibodies following Acute Infectious Mononucleosis.

Weiss ER, Alter G, Ogembo JG, Henderson JL, Tabak B, Bakiş Y, Somasundaran M, Garber M, Selin L, Luzuriaga K.  J Virol. 2016 Oct 12. pii: JVI.01562-16. [Epub ahead of print]. PMID: 27733645 DOI: 10.1128/JVI.01562-16.(Paper)

Longevity of Genotype-Specific Immune Responses to Plasmodium falciparum Merozoite Surface Protein 1 in Kenyan Children from Regions of Different Malaria Transmission Intensity.

Bowman NM, Juliano JJ, Snider CJ, Kharabora O, Meshnick SR, Vulule J, John CC, Moormann AM.   Am J Trop Med Hyg. 2016 Aug 1. pii: 15-0710. [Epub ahead of print].  PMID:  27481054. (Paper)

Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration.

Shin J, Salameh JS, Richter JD.  Sci Rep. 2016 Jul 6;6:29395. doi: 10.1038/srep29395.  PMID: 27381259.  (Paper)

Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative polymerase chain reaction. 

Tanriverdi K, Kucukural A, Mikhalev E, Tanriverdi SE, Lee R, Ambros VR, Freedman JE. Anal Biochem.  2016 May 15;501:66-74. doi: 10.1016/j.ab.2016.02.019. Epub 2016 Mar 10.  PMID:26969789.   (Paper)

Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation.

Smulan LJ,  Ding W, Freinkman E, Gujja S, Edwards Y J.K., Walker, AK.   Cell Rep. 2016 Jun 28;16(1):9-18. doi: 10.1016/j.celrep.2016.05.086. Epub 2016 Jun 16. PMID:27320911. PMCID:PMC4934023 (Paper)

The Centrosome Undergoes Plk1-Independent Interphase Maturation during Inflammation and Mediates Cytokine Release.

Vertii A, Ivshina M, Zimmerman W, Hehnly H, Kant S, Doxsey S.  Dev Cell. 2016 May 23;37(4):377-86. doi: 10.1016/j.devcel.2016.04.023.  PMID: 27219065.  (Paper)

Protein Kinase Mitogen Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-Induced Hyperinsulinemia.

Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Garcia Menendez L, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP.  J Biol Chem. 2016 May 20. pii: jbc.M116.718932. Epub 2016 May 20. PMID:27226575. PMCID:PMC4965570.  (Paper)

Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease.

Lee PL, Tang Y, Li H, Guertin DA.  Mol Metab. 2016 Apr 11;5(6):422-32. doi: 10.1016/j.molmet.2016.04.001. eCollection 2016 Jun.  PMID:  27257602.  (Paper)

Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants.

McManus M, Mick E, Hudson R, Mofenson LM, Sullivan JL, Somasundaran M, Luzuriaga K; PACTG 356 Investigators.  PLoS One. 2016 Apr 22;11(4):e0154391. doi: 10.1371/journal.pone.0154391. eCollection 2016.  PMID: 27104621 [PubMed - as supplied by publisher].  (Paper)

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.

Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA.  Nat Commun. 2016 Apr 21;7:11365. doi: 10.1038/ncomms11365. PMID: 27098609 [PubMed - in process].  (Paper)

Endothelial MAP4K4 is critical for lymphatic vascular development and function.

Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP.   Mol Cell Biol. 2016 Apr 4. pii: MCB.01121-15. [Epub ahead of print].  PMID: 27044870 [PubMed - as supplied by publisher] (Paper)

Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma.

Han MS, Barrett T, Brehm MA, Davis RJ.   Cell Rep. 2016 Mar 24. pii: S2211-1247(16)30249-2. doi: 10.1016/j.celrep.2016.03.008. [Epub ahead of print]. PMID: 27052181 [PubMed - as supplied by publisher].  (Paper)

Genetic link between renal birth defects and congenital heart disease.

San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ.  Nat Commun. 2016 Mar 22;7:11103. doi: 10.1038/ncomms11103.  PMID: 27002738. PMCID:PMC4804176  (Paper)

The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation. 

Hung HF, Hehnly H, Doxsey S.   Curr Biol. 2016 Mar 2. pii: S0960-9822(16)00075-0. doi: 10.1016/j.cub.2016.01.025. [Epub ahead of print].  PMID: 26948879.  (Paper)

Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK.

Vernia S, Cavanagh-Kyros J, Barrett T, Tournier C, Davis RJ.   Cell Rep. 2016 Mar 2. pii: S2211-1247(16)30129-2. doi: 10.1016/j.celrep.2016.02.026. [Epub ahead of print].  PMID: 26947074 [PubMed - as supplied by publisher].  (Paper)

The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans.

Tang W, Tu S, Lee HC, Weng Z, Mello CC.   Cell. 2016 Feb 25;164(5):974-84. doi: 10.1016/j.cell.2016.02.008. PMID: 26919432.  (Paper)

Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress.

Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ.  eLife. 2016 Feb 24;5. pii: e10031. doi: 10.7554/eLife.10031.  PMID: 26910012.  . (Paper)

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.

Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP.  Nat Commun. 2016 Feb 16;7:10686. doi: 10.1038/ncomms10686.  PMID: 26880110.  (Paper)

TNFα-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38α MAPK Pathway. 

Girnius N, Davis RJ.   Cancer Cell. 2016 Feb 8;29(2):131-3.  doi: 10.1016/j.ccell.2016.01.008.  PMID:26859448.   (Paper)

Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.

Min SY, Kady J, Nam M, Rojas-Rodriguez R, Berkenwald A, Kim JH, Noh HL, Kim JK, Cooper MP, Fitzgibbons T, Brehm MA, Corvera S.   Nat Med. 2016 Jan 25. doi: 10.1038/nm.4031. PMID:  26808348.  (Paper)


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