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2022 News

May 3, 2022 - Communicating science: Andrei Korostelev using structural biology to tackle antibiotic resistance

May 2, 2022 - New publication from the Zamore Lab - Principles and pitfalls of high-throughput analysis of microRNA-binding thermodynamics and kinetics by RNA Bind-n-Seq. Jouravleva K, Vega-Badillo J, Zamore PD. Cell Rep Methods. 2022 Mar 18;2(3):100185. doi: 10.1016/j.crmeth.2022.100185. eCollection 2022 Mar 28. PMID: 35475222

April 21, 2022 - New publication from the Watts Lab - Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing. Chen Z, Devi G, Arif A, Zamore PD, Sontheimer EJ, Watts JK. ACS Chem Biol. 2022 Apr 21. doi: 10.1021/acschembio.2c00116. Online ahead of print. PMID: 35446558 35475222

February 17, 2022 - New publication from the Xue Lab - Imaging net retrograde axonal transport in vivo: a physiological biomarker. Ann Neurol.Lee PJ, Kennedy Z, Wang Y, Lu Y, Cefaliello C, Uyan Ö, Song CQ, da Cruz Godinho BM, Xu Z, Rusckowski M, Xue W, Brown RH Jr. . 2022 Feb 17. doi: 10.1002/ana.26329. Epub ahead of print. PMID: 35178738.

January 22, 2022 - New publication from the Pai Lab - Widespread occurrence of hybrid internal-terminal exons in human transcriptomes. Fiszbein A, McGurk M, Calvo-Roitberg E, Kim G, Burge CB, Pai AA.Sci Adv. 2022 Jan 21;8(3):eabk1752. doi: 10.1126/sciadv.abk1752. Epub 2022 Jan 19.PMID: 35044812

January 21, 2022 - New publication from the Sontheimer & Xue Labs - A split prime editor with untethered reverse transcriptase and circular RNA template. Bin Liu, Xiaolong Dong, Haoyang Cheng, Chunwei Zheng, Zexiang Chen, Tomás C. Rodríguez, Shun-Qing Liang, Wen Xue & Erik J. Sontheimer  Nat Biotechnol (2022). https://doi.org/10.1038/s41587-022-01255-9

January 11, 2022 - New publication from the Xue Lab - Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.  Shun-Qing Liang, Pengpeng Liu, Jordan L. Smith, Esther Mintzer, Stacy Maitland, Xiaolong Dong, Qiyuan Yang, Jonathan Lee, Cole M. Haynes, Lihua Julie Zhu, Jonathan K. Watts, Erik J. Sontheimer, Scot A. Wolfe & Wen Xue.  Nat Commun13, 437 (2022). https://doi.org/10.1038/s41467-022-28135-9. 

January 5, 2022 - New publication from the Xue Lab - AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway. Shun-Qing Liang, Christopher J. Walkey, Alexa E. Martinez, Qin Su, Mary E. Dickinson, Dan Wang, William R. Lagor, Jason D. Heaney, Guangping Gao, Wen Xue. Molecular Therapy, Volume 30, Issue 1, 2022, Pages 238-243, ISSN 1525-0016, https://doi.org/10.1016/j.ymthe.2021.10.023.

January 5, 2022 - New publication from the Xue Lab. A flexible split prime editor using truncated reverse transcriptase improves dual AAV delivery in mouse liver.. Zheng C, Liang SQ, Liu B, Liu P, Kwan SY, Wolfe SA, Xue W.  Mol Ther. 2022 Jan 5:S1525-0016(22)00005-3. doi: 10.1016/j.ymthe.2022.01.005. Epub ahead of print. PMID: 34998953.