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2020 News

June 4, 2020 -  MD/PhD-student-led research finds potential new gene target for pediatric liver cancer -  MD/PhD student Jordan Smith, Xue Lab, shares details about new research into a promising therapeutic target for a rare, primarily pediatric liver cancer. UMASS MED NOW

May 27, 2020 - Congratulations to Dr. Erik Sontheimer - his proposal, together with colleagues around the world, Editing the Failing Heart, has been awarded a grant under the Leducq Foundation Network's 2020 Transatlantic Networks of Excellence Program.

May 27, 2020 - Dr. Wen Xue presented "CRISPR-Based In Vivo Genome Editing and Base Editing" webinar - View Now

May 26, 2020 - New publication from the Xue Lab - YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte‐like cells. Jordan L. Smith, Tomás C. Rodríguez, Haiwei Mou, Suet‐Yan Kwan, Henry Pratt, Xiao‐Ou Zhang, Yueying Cao, Shunqing Liang, Deniz M. Ozata, Tianxiong Yu, Qiangzong Yin, Max Hazeltine, Zhiping Weng, Erik J. Sontheimer, Wen Xue. 2020 26 May, AASLD, doi:10.1002/hep.31389

May 19, 2020 - New publication from the Korostelev Lab - mRNA Stem-Loops Can Pause the Ribosome by Hindering A-site tRNA Binding.  Chen Bao , Sarah Loerch , Clarence Ling , Andrei A Korostelev , Nikolaus Grigorieff , Dmitri N Ermolenko. ELife 2020 May 19;9:e55799. doi: 10.7554/eLife.55799

May 18, 2020 - Congratulations to Anastasia Khvorova, Ph.D. for receiving the Women in Science & Health Achievement Faculty Award. 

May 11, 2020 - Anastasia Khvorova elected director of the American Society of Gene and Cell Therapy  UMass Medical School RNA therapeutics expert Anastasia Khvorova, PhD, has been elected by the membership of the American Society of Gene and Cell Therapy to a three-year term as director-at-large/scientific & research council chair, which will begin at the 2020 ASGCT virtual annual meeting.

May 11, 2020 - New publication from the Sontheimer Lab - An engineered ScCas9 with broad PAM range and high specificity and activity. Pranam Chatterjee, Noah Jakimo, Jooyoung Lee, Nadia Amrani, Tomás Rodríguez, Sabrina R. T. Koseki, Emma Tysinger, Rui Qing, Shilei Hao, Erik J. Sontheimer & Joseph Jacobson. Nat Biotechnol (2020). https://doi.org/10.1038/s41587-020-0517-0

May 5, 2020 - New publication from the Watts Lab - Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Chembiochem. 2020 May 5. doi: 10.1002/cbic.202000136. [Epub ahead of print] PMID: 32372560

April 27, 2020 - New publication from the Watts Lab - RNA therapeutics on the rise.
Wang F, Zuroske T, Watts JK.  Nat Rev Drug Discov. 2020 Apr 27. doi: 10.1038/d41573-020-00078-0. No abstract available.

April 24, 2020 - New publicaton from the Xue Lab - Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope  Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu & Wen Xue. Nat Commun 11, 1979 (2020). https://doi.org/10.1038/s41467-020-15892-8

April 23, 2020 - News from the RTI - Erik Sontheimer, Ph.D., Professor and Vice Chair, RNA Therapeutics Institute, amazing scientist and kind and wise colleague, on his being appointed to the Pillar Chair in Biomedical Research. Erik becomes the fourth RTI faculty member to be recognized with an endowed chair position, and the third endowed chair among our current faculty. 

March 19, 2020 - New publication from the Sontheimer Lab - Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems. Davidson AR, Lu WT, Stanley SY, Wang J, Mejdani M, Trost CN, Hicks BT, Lee J, Sontheimer EJ. Annu Rev Biochem. 2020 Mar 18. doi: 10.1146/annurev-biochem-011420-111224. PMID: 32186918

February 4, 2020 - New publication from the Zamore & Gao LabsEffective and Accurate Gene Silencing by a Recombinant AAV-Compatible MicroRNA Scaffold. Xie J, Tai PWL, Brown A, Gong S, Zhu S, Wang Y, Li C, Colpan C, Su Q, He R, Ma H, Li J, Ye H, Ko J, Zamore PD, Gao G. Mol Ther. 2020 Feb 5;28(2):422-430. doi: 10.1016/j.ymthe.2019.11.018. Epub 2019 Nov 27.

January 13, 2020 - New review from the Watts Lab - RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease.  Watts JK, Ockene IS. Nucleic Acid Ther. 2020 Jan 13. doi: 10.1089/nat.2019.0835. PMID: 31928497