RNA Therapeutics Institute Faculty

Focus:
Pathogenesis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease.

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High-resolution electron cryo-microscopy of macromolecular machines to understand their molecular mechanisms and the cellular processes they are involved in.

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Focus:
The interface between microscopy development and (nuclear) cell biology, with a strong focus on the travels of mRNA and nucleocytoplasmic transport.

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Focus:
Development of novel oligonucleotide-based therapeutics, drug development. Mechanism of small RNA trafficing, RNA medicinal chemistry and delivery.

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Focus:
Structure and function of ribosome.

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Focus:
Investigation of the mechanism of RNA interference; investigation of how embryonic cells differentiate and communicate during development.

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Focus:
Post-transcriptional gene regulation in eukaryotes via mechanisms involving RNA.

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Focus:
Kinetics of RNA processing; genetic and genomic investigations of the dynamics of alternative mRNA splicing.

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Focus:
Biology and mechanism of RNA-based gene regulation; CRISPR interference; RNA-directed genome editing and gene control.

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Focus:
Chemistry and chemical biology of oligonucleotides; Nucleic acid drug development.

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Focus:
Mouse models of cancer. Use CRISPR genome editing to functionally dissect cancer mutations in liver and lung cancer.

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Focus:
Dissecting the RNAi and miRNA pathways.

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