Overview Mice2

Cardiovascular Core

The Cardiovascular Core provides state-of-the-art phenotyping of cardiovascular system in mouse models of metabolic disease and an easily accessible cardiovascular disease model pipeline. The Core services enhance whole body metabolic characterization given that cardiovascular complications represent the major source of morbidity and mortality in obesity and diabetes. The Core also offers sophisticated disease models that encompass the three major cardiovascular complications of diabetes: peripheral vascular disease, coronary atherosclerosis, and heart failure. The Core phenotyping services include:

  • 2-D and M-mode echocardiography in lightly-anesthetized mice to non-invasively assess cardiac structure and function using state-of-the-art high-frequency, high-resolution in vivo digital imaging platform (VisualSonics Vevo2100)
  • Non-invasive analysis of diastolic function and strain analysis (radial, circumferential, and longitudinal) using pulsed wave color Doppler mode
  • Non-invasive measurement of blood pressure, ECG, and heart rate
  • In vivo assessment of endothelial function using Danish Myo Technology
  • Quantification of aortic atherosclerosis via in vivo ultrasound and ex vivo en face and aortic root Oil Red O staining
  • Hind Limb Ischemia (HLI) and Abdominal Aortic Aneurysm (AAA) disease models to investigate peripheral vascular disease (PVD)
  • Coronary Artery Ligation (CAL) model to investigate chronic myocardial infarction
  • Transverse Aortic Constriction (TAC) model to investigate pressure-overload hypertrophy, congestive heart failure, and aortic stenosis
DIRECTOR

Timothy P. Fitzgibbons MD, PhD
Division of Cardiovascular Medicine
Worcester MA, 01655
Phone: (508) 856-3905
Fax: (508) 856-4571
timothy.fitzgibbons@umassmemorial.org

Fitzgibbons

CO-DIRECTOR

John F. Keaney Jr, M.D. 
Professor of Medicine
Chief, Cardiovascular Medicine
Phone: (508) 856-6907 
Fax: (508) 856-6933 
john.keaney@umassmed.edu

John Keaney

ADDRESS:

University of Massachusetts Medical School
368 Plantation Street
The Albert Sherman Center
9th Floor, Room 1015
Worcester, MA 01605

 
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