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Identifying Novel Cancer Genes and correcting disease genes

Identify novel cancer genes and correct disease gene through CRISPR-mediated genome editing

We are using CRISPR-mediated genome editing to identify novel cancer genes and fix disease genes in vivo. The CRISPR/Cas9 genome editing tools have been successfully applied in many organisms, including mouse and human cells. Given the number of candidate cancer genes being discovered through cancer genome sequencing efforts, simplified methods of testing candidate genes in vivo are critical.

To identify novel cancer genes, we plan to perform in vivo sgRNA validation and sgRNA screening in mouse models of adult liver cancer and childhood hepatoblastoma (Xue et al, Nature, 2014; S├ínchez-Rivera et al, Nature, 2014; ). We will also explore proof-of-concept disease gene correction of Tyrosinemia type I, alpha 1 antitrypsin and other genetic disease in mice (Yin, Xue, et al, Nature Biotech, 2014Yin et al, Nature Biotech, 2016).

Our study will harness the power of the CRISPR/Cas9 system for developing novel cancer models in the mouse. Read more about our study here

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