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RTI Bullet 8/19/2019 Congratulations to Zack Kennedy.  "For ALS medical scientist, finding a cure is personal". Farragher, Thomas (2019) Boston Globe. 

RTI Bullet 8/11/2019 A paper led by Jooyoung Lee in the Sontheimer lab is accepted by RNA.

RTI Bullet 8/9/2019 Ankur and Zack successfully passed PhD defense. Congrats! 

RTI Bullet 7/28/2019 Jordan Smith is selected to present a talk at the UMassmed retreat. Congrats! 

RTI Bullet 7/25/2019 Dr. Xue presented an invited talk at the Society of Chinese Bioscientists in America (SCBA) symposium, Kunming, China.

RTI Bullet 7/01/2019 Xue lab and Gao lab received a 3 year grant from the Cystic Fibrosis Foundation. Many thanks for the support!
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RTI Bullet 6/28/2019 Xue lab at the RTI symposium. 
      

RTI Bullet 6/26/2019 Ankur's co-author paper with the Mercurio lab is accepted by Journal of Cell Science. Congrats! Link

RTI Bullet 5/27/2019 Suet-Yan and Ankur's paper is accepted by Hepatology. Congrats! Link
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RTI Bullet 5/1/2019 Dr. Xue is invited to give a talk at the SCBA annual meeting. 

RTI Bullet 4/16/2019 Dr. Xue is invited to give a talk at the ASGCT annual meeting. 

RTI Bullet 4/2/2019 Dr. Xue is selected as an editorial board member of the FASEB journal.

RTI Bullet 4/1/2019 Dr. Xue is selected to serve as a member of the Cancer Gene & Cell Therapy Committee and the Gene & Cell Therapy of Genetic and Metabolic Diseases Committee of the American Society of Gene & Cell Therapy.

RTI Bullet 3/8/2019 Haiwei, Deniz and Jordan's paper is accepted by Genome Medicine. Congrats! Link
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RTI Bullet 2/18/2019 Jordan Smith received a F30 fellowship from NCI. Congrats! 

RTI Bullet 2/11/2019 Ankur Sheel and Jordan Smith are selected to present short talks at the MCCB cancer retreat. 

RTI Bullet 2/11/2019 Ankur Sheel is selected to present a short talk at the UMMS MD/PhD retreat. 

RTI Bullet 1/21/2019 CRISPR–Cas: a tool for cancer research and therapeutics. by Hao Yin, Wen Xue & Daniel Anderson is published by Nature Reviews Clinical OncologyLink
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RTI Bullet 1/16/2019 Chunqing and Tingting's paper with David Liu and Hao Yin's labs is accepted by Nature biomedical engineering. Congrats!
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RTI Bullet 12/20/2018 A co-authored paper with Dr. Erik Sontheimer is published in Molecular Cell. Link

RTI Bullet 12/20/2018 A co-authored paper with Drs Scott Lowe and Carol Prives is published in Cell. Link

RTI Bullet 12/11/2018 Dr. Xue presented at the NIH somatic cell genome editing workshop. 

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 12/01/2018 Xue lab received NIH somatic cell genome editing funding with the Gao lab to improve genome editing techniques. Link

RTI Bullet 11/09/2018 Dr. Xue presented an invited talk at the SCBA Hepatology Division First Annual Scientific Symposium.

RTI Bullet 11/05/2018 Jordan and Haiwei's Research Highlight paper is published in Genome BiologyLink

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RTI Bullet 09/21/2018 A collaboration with Dr. Sontheimer's lab is published in Genome Biology. Link

RTI Bullet 08/27/2018 A collaboration with Dr. Weng's lab is published in PLoS GeneticsLink

RTI Bullet 08/14/2018 Chunqing's paper is selected as the cover for Human Gene TherapyLink. A nice editorial by Dr. Flotte. Link.
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RTI Bullet 08/04/2018 Zack Kennedy received a travel grant from the Oligonucleotide Therapeutics Society. Congrats! 

RTI Bullet 07/05/2018 Ankur Sheel received a F30 fellowship from NCI. Congrats! 

RTI Bullet 06/28/2018 Ankur Sheel chaired a session at the RTI symposium. 

RTI Bullet 06/20/2018 UMass cancer walk fundraisers visited the Xue lab.

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06/15/2018 Chunqing Song received a faculty position at the Xihu University. Congrats!

RTI Bullet 06/02/2018 Dan Wang's paper is accepted by Nature Biotechnology. New publication from Xue, Zamore, and Gao labs. Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Dan WangJia LiChun-Qing SongKaren TranHaiwei MouPei-Hsuan WuPhillip W L TaiCraig A MendoncaLingzhi RenBlake Y WangQin SuDominic J GesslerPhillip D ZamoreWen Xue & Guangping Gao. Nat Biotechnol. 2018. Link
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RTI Bullet 05/09/2018 Dr. Xue gave a talk at the Alpha-1 Support day event.

RTI Bullet 04/05/2018 The Xue lab received funding as part of Dr. Erik Sontheimer's grant from UMASS Center for Clinical and Translational Science (UMCCTS). Many thanks for the support from UMass CCTS. 
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RTI Bullet 03/19/2018 Chunqing's paper with Dr. Flotte is published in Human Gene TherapyLink

RTI Bullet 02/14/2018 Chunqing's review article is published in Nature Reviews Gastroenterology & HepatologyLink
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RTI Bullet 01/01/2018 Dr. Xue is invited to give a talk at the AACR annual meeting, Chicago.

RTI Bullet 12/11/2017 Chunqing and SuetYan's paper (with Hao Yin, Bob Langer and Dan Andersonon) is accepted by Nature Chemical BiologyLink
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RTI Bullet 11/18/2017 SuetYan gave an invited talk at the RNA Summit meeting, Boston. 

RTI Bullet 08/25/2017 A paper led by Hao Yin, Bob Langer and Dan Andersonon is accepted by Nature Biotechnology. Chunqing, Haiwei and SuetYan in the Xue lab are co-authors. Link
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RTI Bullet 08/02/2017 A paper led by Dr. Xin Wei Wang at NCI is published in Cancer Cell. Link

RTI Bullet 08/02/2017 Jordan Smith has been selected for the UMass Cancer Biology T32 fellowship. The selection process this year was extremely competitive. Big congrats!

RTI Bullet 07/03/2017 Dr. Xue is invited to give a talk at the American Association for the Study of Liver Diseases (AASLD) meeting, Washington, DC.

RTI Bullet 06/14/2017 An editorial  on how CRISPR induces exon skipping & what does it mean for your experiments. Link

RTI Bullet 05/01/2017 Haiwei and Jordan's paper is accepted by Genome Biology. Congrats!
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RTI Bullet 04/01/2017 Dr. Xue is invited to give a talk on CRISPR mouse models at the American Gastroenterological Association (AGA) Digestive Disease Week, Chicago.

RTI Bullet 04/01/2017 Great editorial on 's paper in Gastroenterology:Cancer Gene Discovery in Hepatocellular Carcinoma: The CRISPR/CAS9 Accelerator 

RTI Bullet 03/20/2017 Haiwei Mou's paper with Dr. Michal Green is published in PNAS. Congrats! 

RTI Bullet 02/03/2017 The Xue lab received funding as part of Dr. Robert Brown's grant from the ALS Association to the ALS ONE-Massachusetts Partnership. Many thanks for the great support.

RTI Bullet 02/01/2017 Zack Kennedy is selected to give a talk at the American Academy of Neurology 69th Annual Meeting.

RTI Bullet 12/04/2016 Chun-Qing Song, Yingxiang Li and Haiwei Mou's paper on CRISPR screen is accepted by Gastroenterology (impact factor 18). Many thanks to our collaborators: Drs. Zhiping Weng, Xin Wei Wang (NCI), and Snorri Thorgeirsson (NCI).
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RTI Bullet 11/16/2016 UMass cancer walk fundraisers visited the Xue lab.
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RTI Bullet 11/10/2016 Chun-Qing Song is invited to speak at the CRISPR congress meeting.

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10/04/2016 Dr. Xue is awarded the 2016 NIH Director's New Innovator Award. Wen's project titled "CRISPR-BASED MODULAR THERAPY FOR PRECISION MEDICINE " is part of a NIH High-Risk, High-Reward Research (HRHR) program supporting highly creative and exceptional scientists with bold approaches to major challenges in biomedical research. This award will be for five years, total about 2.5 millon dollars. For more, please click here.
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RTI Bullet 09/23/2016 The Xue lab receives $250,000 for pediatric cancer research from Hyundai Hope on Wheels. Many thanks for the great support from Hyundai. For more, please click here.Kenneth Laferriere helps his son, Kaiden, put a red handprint on the pocket of the new Hyundai Hope on Wheels lab coat given to grant awardee Wen Xue, PhD.
(Kenneth Laferriere helps his son, Kaiden, put a red handprint on the pocket of the new Hyundai Hope on Wheels lab coat given to grant awardee Wen Xue, PhD.)

RTI Bullet 09/16/2016 The Xue lab was selected to receive a $150,000, 2 years award from The Lung Cancer Research Foundation (LCRF). Many thanks for the continued support from LCRF.
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RTI Bullet 08/19/2016 Dr. Xue presented a short talk at the CSHL meeting GenomeEngineering: The CRISPR/Cas 9 Revolution.

RTI Bullet 08/10/2016 The Xue lab received a subproject of a five-year P01 grant (PI: Dr. Terence Flotte) from NIH/NHLBI. The Xue lab will receive about 1.5 millon dollars in direct cost to develop new genome editing tools. Many thanks to our collaborators Drs. Terence Flotte, Guangping Gao, Christian Mueller, and Mai ElMallah. For more, please click here.
Members of the program project grant team, left to right, include Terence R. Flotte, MD; Wen Xue, PhD; Guangping Gao, PhD; Christian Mueller, PhD; and Mai ElMallah, MD.

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RTI Bullet 08-02-2016 New publication from the Xue lab. Ankur Sheel's "in the spotlight" article is online at Cancer Discovery. Big congrats! Many thanks to Dr. Darryl Conte for his great edits.

RTI Bullet 07-18-2016 Dr. Xue will attend American Cancer Society's annual "Making Strides Against Breast Cancer kickoff breakfast" at WPI on July 23rd.

RTI Bullet 07-06-2016 Dr. Xue was interviewed by Lung Cancer Research Foundation (LCRF). The article will be published in LCRF's annual report.

RTI Bullet 06-03-2016 Haiwei Mou presented a poster at the 81st Cold Spring Harbor Laboratory Symposium - Targeting Cancer.

RTI Bullet 05-11-2016 Dr. Xue attended UMass inKNOWvation event, "The Return of Gene Therapy".

RTI Bullet 04/11/2016 The Xue lab won research grant from UMASS Center for Clinical and Translational Science (UMCCTS) Pilot Award. Many thanks for the support from UMass CCTS.
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RTI Bullet 04/07/2016 The Xue lab won research grant from American Cancer Society. The $791,000 in funds will support studying KRAS inhibition in lung cancer. Many thanks for the support from ACS. For more, please click here
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RTI Bullet 03/25/2016 The Xue lab is feasured in a Nature News article about our CRISPR work.

RTI Bullet 03/04/2016 Chun-Qing Song is invited to speak at the Harvard-Yale Symposium IBC Symposium: CRISPR/Cas9 Research Risks Intersection of Science, Safety and Policy.

RTI Bullet 02/24/2016 Dr. Xue gave a invited talk at the 2nd CRISPR congress meeting.

 

RTI Bullet 02/01/2016

NBT paper is online. Therapeutic genome editing by “This finding really excites us because it makes us think that this is a gene repair system that could be used to treat a range of diseases — not just tyrosinemia but others as well,” Daniel Anderson says.combined viral and non-viral delivery of CRISPR system components to the mouse liver. 

“This finding really excites us because it makes us think that this is a gene repair system that could be used to treat a range of diseases — not just tyrosinemia but others as well,” says Dr. Daniel Anderson.

“It’s really exciting to see our team develop this new delivery approach for CRISPR, which I believe has the potential to have far-reaching implications,” says Dr. Robert Langer.Image Ernesto del Aguila III/NHGRI

Nat Biotechnology. 2016 Link   PDF

CRISPR/Cas9 therapeutic for Tyrosinemia type I delivered to mice (UMass Med Now)
Curing disease by repairing faulty genes (MIT news)

RTI Bullet 01/20/2016

Dr. Xue is invited to give a talk at the Fourth Symposium on Translational Genomics with a Special Focus on Liver Cancer at NCI.

RTI Bullet 01/05/2016 Chunqing Song presented at the CRISPR supergroup. Well done!

RTI Bullet 12-01-2015 A co-authored paper led by Dr. Hao Yin at MIT is accepted by J Hepatology. The title is "Control of liver size by RNAi-mediated multiplex knockdown and its application for discovery of regulatory mechanisms". Link
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RTI Bullet 11-14-2015 Dr. Xue was invited to give a lecture at "The 18th SAPA-NE Scientific Symposium - The New Era of Gene Therapy".

RTI Bullet 11-07-2015 New publication with Dr. Xin Wei Wang at NCI.   Xue W#, Wang XW#. The search for precision models clinically relevant to human liver cancer. Hepatic Oncology. (Editorial) Vol. 2, No. 4,  315-319. (# co-corresponding authors) Link
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 RTI Bullet 10-29-2015 Dr. Xue received Award from Dr. Jan Baranski, Director of Scientific Programs of LCRF at the 10th Annual Lung Cancer Awareness Luncheon in NYC. "The LCRF Scientific Merit Award acknowledges the investigator whose proposal was selected for outstanding overall merit by the Foundation's Scientific Advisory Board. Dr. Xue received the accolade for his research targeting small RNA-mediated KRAS inhibition in lung cancer". News Release

Quote from LCRF: "Among those newly awarded is Wen Xue, PhD, assistant professor at the RNA Therapeutics Institute at the University of Massachusetts Medical School. Dr. Xue also received the LCRF Scientific Merit Award, which acknowledges the investigator whose proposal was selected for outstanding overall merit by the Foundation's Scientific Advisory Board. Dr. Xue received the accolade for his research targeting small RNA-mediated KRAS inhibition in lung cancer. "Continued support for lung cancer research is critical to driving advancements in the field. I'm thankful to LCRF for believing in this important research, which will potentially lead to better patient outcomes." said Dr. Xue. "
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RTI Bullet10-21-2015 A paper led by Elliot Akama-Garren and Nik Joshi in Dr. Tyler Jacks's lab is accepted by Scientific Reports. Akama-Garren E, Joshi N, Tammela T, Chang G, Wagner B, Lee D, Rideout W, Papagiannakopoulos T, Xue W, and Jacks T. A Modular Assembly Platform for Rapid Generation of DNA Constructs.
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RTI Bullet 10-20-2015 Haiwei presented at the RNA club "Overcome resistance to Kras silencing in lung cancer". Well done.

RTI Bullet 10-08-2015 Dr. Xue was selected to receive the 2015 Scientific Merit Award of the Lung Cancer Research Foundation (LCRF).  News Release

RTI Bullet 10-08-2015 The Xue lab won a 2015 Lung Cancer Research Foundation (LCRF) grant  for the project titled " Small RNA-mediated KRAS inhibition in lung cancer". For details, click here.
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RTI Bullet 09-25-2015 Dr. Xue presented at the CSHL Meeting on GENOME ENGINEERING: THE CRISPR/CAS REVOLUTION on liver cancer mouse models.
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RTI Bullet 09-22-2015 Dr. Xue was invited to present a lecture at "Discovery on Target: Developing CRISPR-based Therapies, 2015" in Boston.
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RTI Bullet 09-05-2015 Dr. Xue was selected as a co-chair with Dr. Xinwei Wang to organize a Special Interest Groups (SIGs) Workshop at the 9th annual meeting of International Liver Cancer Association (ILCA).Link
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RTI Bullet 08-10-2015 Dr. Xue is selected to join the Editorial Board of Human Gene Therapy. Link

RTI Bullet 06-19-2015 Haiwei's CRISPR paper is published in Human Gene Therapy. This work is in collaboration with Drs. Dan Anderson, Erik Sontheimer, Zhiping Weng and Guangping Gao. 
Wang D*, Mou H*, Li SY*, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer EJ, Weng Z#, Gao G#, Xue W#. Adenovirus-mediated somatic genome editing of Pten by CRISPR/Cas9 in mouse liver in spite of Cas9-specific immune responses. Human Gene Therapy. ahead of print. (2015) Link

 

RTI Bullet 06-11-2015 A new CRISPR review from the Xue lab published in Genome Medicine. Congrats to Haiwei and Zack.
Mou H, Kennedy Z, Anderson DG, Yin H#, and Xue W#. Precision cancer mouse models through genome editing with CRISPR-Cas9. Genome Medicine, 7(1):53 (2015) Link

RTI Bullet 06-1-2015 We received the U Mass President’s Science and Technology (S&T) Fund. Special thanks to our collaborators Drs. Vincent Rotello, Arthur Mercurio, Michael Lee, Shelly Peyton and Alfred Crosby at U Mass.

RTI Bullet 05-14-2015 Yingxiang, Angela and Haiwei's paper in collaboration with Dr. Zhiping Weng's lab is accepted by Genome Biology. Congrats!

Li Y*, Park A*, Mou H*, Colpan C, Bizhanova A, Akama-Garren E, Joshi N, Hendrickson EA, Feldser D, Yin H, Anderson DG, Jacks T, Weng Z#, Xue W#. A versatile reporter system for CRISPR-mediated chromosomal rearrangements. Genome Biology, 16(1):111. (# co-corresponding authors) Link
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RTI Bullet 04-14-2015 We are funded by the 2015 Worcester Foundation grant.

RTI Bullet 04-03-2015 Angela presented at the CRISPR Supergroup meeting. Well done.

RTI Bullet 03-19-2015 Two co-authored papers published with Dr. Dan Anderson and Dr. Scott Powers!

Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes C, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie J, Jacks T, Langer R, Anderson DG. Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature. Nano Lett. 2015. Link

Li J, Chanrion M, Sawey E, Wang T, Chow E, Tward A, Su Y, Xue W, Lucito R, Zender L, Lowe SW, Bishop JM, Powers S. Reciprocal Interaction of Wnt and RXR-α Pathways in Hepatocyte Development and Hepatocellular Carcinoma. PLoS One. 10(3):e0118480. (2015)

 RTI Bullet 01-13-2015 "A Giant Step for Gene Surgery". The CRISPR paper on correcting the tyrosinemia type I gene in preclincial mouse models was voted one of the top 100 stories of 2014 by Discover magazine. Link  

RTI Bullet 12-16-2014  First group meeting. 

 RTI Bullet 10-22-2014 Dr. Xue is a senior co-author of the Jacks lab paper entitled "Rapid modeling of cooperating genetic events in cancer through somatic genome editing", featuring the novel CRISPR/Cas9-based technology to quickly investigate the function of candidate-genes in the well-established autochthonous mouse model of cancer. Nature Advance Online Publication on Oct. 22 and also at the MIT webpage!  Read more >>

"Sánchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, Bhutkar A, Joshi NS, Subbaraj L, Bronson RT, Xue W, Jacks T. Nature. 2014 doi: 10.1038/nature13906"

RTI Bullet 10-16-2014 Dr. Xue is the first author of the Jacks lab paper entitled "CRISPR-mediated direct mutation of cancer genes in the mouse liver", featuring the novel CRISPR/Cas9-based technology to quickly model cancer mutations in liver cancer. Nature Publication on Oct. 16 and also at the MIT webpageRead more >>

 RTI Bullet Erasing a genetic mutation. Researchers reversed a liver genetic disorder hereditary tyrosinemia type I in mice by correcting a mutated gene Fah. The findings, described in the March 30 issue of Nature Biotechnology, offer the first evidence that this gene-editing technique, known as CRISPR, can reverse disease symptoms in living animals. Read more >> Nature Medicine comments



 

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