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Thomas Fazzio, PhD

Research Focus - Mechanisms of Gene Regulation in Development and Disease

  • Understanding the developmental functions of ATP-dependent nucleosome-remodeling factors, which constitute the most highly mutated classes of genes in cancer
  • Developing new genomic technologies for the study of rare cell populations in development and disease
  • Characterizing the functions and regulation of the Tip60-p400 complex, a histone acetyltransferase and nucleosome-remodeling enzyme that is mutated in some cancers   
  • Elucidating the mechanisms of chromatin remodeling in stem cells and cell fate specification

Representative Publication

Gopalan S, Wang Y, Harper NW, Garber M, Fazzio TG. Simultanous profiling of multiple chromatin proteins in the same cells. Mol Cell. 2021;81(22):4736-4746.

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In the News

Getting Results…
  • UMass Cancer Center funds five UMass Chan research projects

    UMass Cancer Center funds five UMass Chan research projects

    The UMass Cancer Center Pilot Project Program has awarded seed grants to five UMass Chan Medical School research projects to enable investigators to gather pilot data for external cancer-focused funding.

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