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Shaoguang Li, MD, PhD

Research Focus - Molecular Basis of Leukemogenesis and Myeloproliferative Neoplasms

  • Understanding the biology of leukemia stem cells (LSCs)
  • Identification of molecular targets specific for LSCs
  • Elucidation of signaling pathways critical for the development of myeloproliferative neoplasms (MPNs), with a focus on polycythemia vera (PV) induced by JAK2V617F
  • Understanding the biology of PV-initiating cells
  • Characterization of the self-renewal mechanisms of normal hematopoietic stem cells

Representative Publication

Chen Y, Shan Y, Lu M, et al. Alox5 blockade eradicates JAK2V617F-induced polycythemia vera in mice. Cancer Res. 2017;77(1):164-174.

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