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Michael P. Czech, PhD

Research Focus - Progression from Diabetes and Nonalcoholic Steatohepatitis to Hepatocellular Carcinoma

  • Elucidation of the mechanisms underlying the progression from fatty liver disease to fibrosis and cancer
  • Characterization of paracrine signaling from hepatocytes to Kupffer and stellate cells
  • Study of liver inflammation and its relation to fatty acid synthesis and storage
  • Examination of adipocyte metabolism in control of liver function
  • Therapeutic development of "self-delivery" RNAi for liver fibrosis and cancer

Representative Publication

Tencerova M, Aouadi M, Vangala P, et al. Activated Kupffer cells inhibit insulin sensitivity in obese mice. FASEB J. 2015;29(7):2959-2969.

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