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About

Located in Worcester, Massachusetts, the UMass Cancer Center is committed to providing exceptional patient care, conducting cutting-edge research at the highest level, offering excellence in education and training, and serving as an educational resource and advocate for the Central Massachusetts community.
Patients
Patients

Expert Cancer Care in Central Massachusetts

We offer comprehensive cancer care for all childhood and adult cancers, combining state-of-the-art treatments with compassionate support for patients and their families.
Clinicians
Research
Research

Cutting-Edge Cancer Research

We carry out front-line research in basic, translational, clinical and population-based discovery to find newer, better methods for the prevention, detection, diagnosis, and treatment of cancer.
Education
Education

World Class Medical and Scientific Education

The UMass Cancer Center is dedicated to training the next generation of cancer researchers, clinicians and physician-scientists.
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Michael P. Czech, PhD

Professor, Program in Molecular Medicine; Isadore and Fannie Foxman Chair of Medical Research, UMass Chan Medical School

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Michael P. Czech, PhD

Research Focus - Progression from Diabetes and Nonalcoholic Steatohepatitis to Hepatocellular Carcinoma

Elucidation of the mechanisms underlying the progression from fatty liver disease to fibrosis and cancer
Characterization of paracrine signaling from hepatocytes to Kupffer and stellate cells
Study of liver inflammation and its relation to fatty acid synthesis and storage
Examination of adipocyte metabolism in control of liver function
Therapeutic development of "self-delivery" RNAi for liver fibrosis and cancer

Tencerova M, Aouadi M, Vangala P, et al. Activated Kupffer cells inhibit insulin sensitivity in obese mice. FASEB J. 2015;29(7):2959-2969.