Marcus Ruscetti, PhD

Research Focus - Harnessing Intrinsic Tumor Suppressor Pathways to Restore Anti-Tumor Immunity

• Dissecting the transcriptional and epigenetic regulation of a tumor suppressive process known as cellular senescence in different tumor contexts
• Harnessing the senescence-associated secretory phenotype (SASP) to reengage immune surveillance and overcome immunotherapy resistance in pancreatic cancer
• Elucidating and targeting genetic mediators of immune escape in prostate cancer metastasis using an innovative mouse modeling approach
• Uncovering mechanisms of resistance to RAS targeted therapies and senescence and immune surveillance bypass in lung cancer

Representative Publication

Ruscetti M, Morris JP IV, Mezzadra, R et al. Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer. Cell 2020;181(2):424-441.

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