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Lucio H. Castilla, PhD

Research Focus - Hematopoietic Differentiation and Acute Myeloid Leukemia

  • Understand the mechanisms that trigger pre-leukemic and stem and progenitor cell expansion and leukemia development
  • Study of pathways altered by core binding factor mutations that regulate oncogenic programs in hematologic malignancies
  • Elucidate the processes that drive clonal hematopoiesis in genetics disorders with predisposition to hematologic malignancies
  • Development of targeted therapies for acute myeloid leukemia

Representative Publication

Pulikkan JA, Hegde M, Ahmad HM, et al. CBFβ-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia. Cell. 2018;174(1):172-186.

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