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Located in Worcester, Massachusetts, the UMass Cancer Center is committed to providing exceptional patient care, conducting cutting-edge research at the highest level, offering excellence in education and training, and serving as an educational resource and advocate for the Central Massachusetts community.
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Expert Cancer Care in Central Massachusetts

We offer comprehensive cancer care for all childhood and adult cancers, combining state-of-the-art treatments with compassionate support for patients and their families.
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Research

Cutting-Edge Cancer Research

We carry out front-line research in basic, translational, clinical and population-based discovery to find newer, better methods for the prevention, detection, diagnosis, and treatment of cancer.
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Education

World Class Medical and Scientific Education

The UMass Cancer Center is dedicated to training the next generation of cancer researchers, clinicians and physician-scientists.
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Michael Green Memorial
Michael Green Memorial

UMass Chan lost one of its greats when Michael R. Green, MD, PhD, passed away unexpectedly in February 2023. We've established these web pages in his memory so our visitors can take a few minutes, from time to time, to peruse and remember him.

Donate to the The Michael R. Green, MD, PhD, Award in Graduate Research:

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Leslie M. Shaw, PhD

Professor, Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School

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Leslie M. Shaw, PhD

Research Focus - Mechanisms of Breast Cancer Progression

Insulin signaling and the role of insulin receptor substrate (IRS) proteins in breast cancer progression
Structure/function analysis of IRS proteins
Connection between obesity and breast cancer progression
IRS2 function in pleomorphic invasive lobular breast cancer
Beclin 1 regulation of endocytic receptor trafficking and tumor progression

Zhu S, Ward BM, Yu J, et al. IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. JCI Insight. 2018;3(8):e97398.