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Elinor Karlsson, PhD

Research Focus - Using Comparative Genomics and Pet Dogs to Develop New Models for Human Cancers

  • Developing blood biopsy techniques for improved diagnosis and treatment of cancer, and earlier detection of recurrences
  • Engaging directly with dog owners to advance dog cancer research, using a citizen science approach modeled on the Count Me In Initiative for rare human cancers
  • Finding new canine models for human cancers through machine learning-based analyses of genomic datasets
  • Searching for new therapeutic targets in the mutational landscape of tumors that are rare in humans but common in dogs, such as osteosarcoma, angiosarcoma and lymphoma

Representative Publication

Megquier K, Turner-Maier J, Swofford R, et al. Comparative genomics reveals shared mutational landscapes in canine hemangiosarcoma and human angiosarcoma. Mol. Cancer Res. 2019;17(12):2410-2421.

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More Publications

In the News

Getting Results…
  • UMass Chan study shows canine behavior only slightly influenced by breed
    Research News

    UMass Chan study shows canine behavior only slightly influenced by breed

    A UMass Chan Medical School genetic study of more than 2,000 purebred and mixed-breed dogs, published in Science, shows that behavioral traits in dogs are not specific for breed. That means a golden retriever, for example, is only slightly more likely to be friendly than another breed.

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  • Elinor Karlsson explains global effort to map genomes of all plants, animals, fungi and more
    Research News

    Elinor Karlsson explains global effort to map genomes of all plants, animals, fungi and more

    In a new PNAs paper, Elinor Karlsson, PhD, said that by comparing genomes between species, scientists can “access the results of a natural experiment carried out on an unfathomable scale.”

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  • Scientists sequence genomes of 240 animals to understand evolution at DNA level
    Research News

    Scientists sequence genomes of 240 animals to understand evolution at DNA level

    A multidisciplinary team of scientists led by Elinor Karlsson, PhD, has captured biodiversity at a genetic level, according to a new study published in Nature.

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