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Brian Lewis, PhD

Research Focus - Elucidating Mechanisms of Tumor Initiation and Progression

  • Development of novel, genetically engineered mouse models of pancreatic and hepatic tumorigenesis
  • Identification of factors required for KRAS-driven pancreatic tumor development and progression
  • Interrogation of signal transduction changes following inhibition of key signaling pathways in pancreatic cancer cells
  • Identification and characterization of drivers of hepatocellular carcinoma dissemination

Representative Publication

Driscoll DR, Karim SA, Sano M, et al. mTORC2 signaling drives the development and progression of pancreatic cancer. Cancer Res. 2016;76(23):6911-6923.

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In the News

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  • Communicating science: Brian Lewis discusses overcoming therapeutic resistance in pancreatic cancer
    Research News

    Communicating science: Brian Lewis discusses overcoming therapeutic resistance in pancreatic cancer

    Brian Lewis, PhD, is studying therapeutic resistance in pancreatic cancer cells, hoping to change the grim statistics for patients diagnosed with pancreatic cancer.

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  • Immunology and microbiology PhD candidate aims to use her voice in science policy career
    Education News, Media

    Immunology and microbiology PhD candidate aims to use her voice in science policy career

    PhD candidate Sarah Cleveland’s mission is to ensure that diverse voices are represented and heard. Cleveland, who studies mechanisms of T cell tolerance, wants to pursue a career in science policy after earning her degree.

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  • David McManus and Brian Lewis named to endowed chairs
    Community News

    David McManus and Brian Lewis named to endowed chairs

    The University of Massachusetts Board of Trustees approved two “accomplished and visionary” University of Massachusetts faculty as endowed chairs at its April meeting.

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  • Brian Lewis recognized at Biomedical Science Careers Program Evening of Hope 2020
    Community News

    Brian Lewis recognized at Biomedical Science Careers Program Evening of Hope 2020

    Brian Lewis, PhD, was recognized in the Evening of Hope 2020 Honor Roll during the Biomedical Science Careers Program’s annual fundraising ceremony. He was honored for his commitment to the organization’s mission of closing the equity gap and increasing diversity in science professions.

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