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Arthur M. Mercurio, PhD

Research Focus - Cell Biology of Aggressive Carcinomas: Mechanisms and Therapy

  • Examination of mechanisms that sustain cancer stem cells (CSCs)
  • Characterization of non-cell autonomous regulation of CSCs
  • Understanding the role of integrins and the extracellular matrix in CSCs and aggressive behavior
  • Elucidation of the non-angiogenic functions of vascular endothelial growth factor (VEGF) and its receptors (neuropilins) on CSCs
  • Therapeutic targeting of neuropilins
  • Study of the cell biology of ferroptosis and development of its therapeutic potential

Representative Publication

Brown CW, Chhoy P, Mukhopadhyay D, et al. Targeting prominin2 transcription to overcome ferroptosis resistance in cancer. EMBO Mol Med. 2021;13(8):e13792.

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