Andreas Bergmann, PhD

Research Focus - Role of Apoptotic Signaling in Cancer

• Activated caspases can trigger a form of compensatory proliferation, referred to as apoptosis-induced proliferation (AiP), through secretion of mitogens
• Sustained AiP can cause tissue overgrowth, and may contribute to tumor growth and treatment resistance
• AiP is best characterized in epithelial cells, and is critical forepithelial wound repair and regeneration across species
• AiP can trigger an inflammatory response that attracts tumor-associated macrophages to tumor tissue

Representative Publication 

Pérez E, Lindblad JL, Bergmann A. Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila. eLife 2017;6:e26747.

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