Amir Mitchell, PhD

Research Focus - Tumor-Microbiome Interactions and Their Effects on Disease Progression and Treatment Success

• Physiological and evolutionary adaptation within the tumor-microbiome to the unique conditions of the tumor niche
• Influences of the microbiome on anticancer drug sensitivity through direct bacterial-drug interactions
• Spatial organization in infected tumors and bacterial influence on gene expression, cellular signaling, and cell-cell communication
• Cell-cell variation within isogenic populations of cancer cells and its effects on signaling dynamics, gene expression, and drug sensitivity

Representative Publication

Rosener B, Sayin S, Oluoch PO, et al. Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host. eLife 2020;9:e59831.

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