Investigational Drug Study For Patients With Rhabdomyosarcoma
Seeking male & female patients who have been diagnosed with rhabdomyosarcoma (cancer that forms in the soft tissues, such as muscle).
Healthy Volunteers Wanted
Clinical Research and Trials
Clinical researchers at the UMass Cancer Center are actively engaged in cutting-edge clinical research trials, both at the local and national levels, to evaluate new chemotherapy treatment options for a variety of cancers, improve surgical procedures for quality and outcomes improvement, and identify novel markers for diagnostic and prognostic predictors of outcome. We perform collaborative translational research, which focuses on iterative feedback loops between the basic science and clinical research domains to accelerate knowledge translation from the bedside to the bench, and back again.
Currently Recruiting Trials
View more trials at Conquering DiseasesRhabdomyosarcoma
Cancer Genetics
Project: Every Child For Younger Patients With Cancer
Seeking Male and Female age 0-25 years who may have cancer or another condition that is characterized by abnormal cell growth but may be benign (not cancer), or may already have been diagnosed with cancer.
Healthy Volunteers WantedKidney Cancer
Study Of Kidney Tumors In Younger Patients
Seeking Male & Female patients age 0-30 years who have a kidney tumor (an abnormal growth of cells or tissues in the kidney that may be benign or malignant) or a tumor outside the kidney called a malignant rhabdoid tumor or an extrarenal Wilms tumor.
Healthy Volunteers WantedGerm Cell Cancer
A Study Of Treatments For Pediatric And Adult Patients With Germ Cell Tumors
We are studying how well active surveillance, or two different combinations of chemotherapy work in treating children 11 and older and adults under age 25 with germ cell tumors.
Healthy Volunteers WantedProstate Cancer
Study Of An Investigational Drug For Prostate Cancer
Volunteers with advanced prostate cancer that has spread to their bones sought for a study of an investigational drug to assess if it stops the cancer from growing
Healthy Volunteers WantedLung Cancer
Study Of Using Tumor Biomarkers To Guide Treatment For Non-Small Cell Lung Cancer
Seeking adults with non-small cell lung cancer for a study comparing immunotherapy to targeted therapy based on tumor characteristics
Healthy Volunteers WantedBlood Cancer
Study Of An Investigational Drug For Relapsed Or Refractory Cd22+ B-Acute Lymphoblastic Leukemia (B All)
Seeking children and young adults whose CD22+ B-Acute Lymphoblastic Leukemia (B ALL) has come back (relapsed) after treatment or has not responded (refractory) for a study of an investigational drug. While the investigational drug has been approved for use adults with leukemia, it has not yet been approved for use in children.
Healthy Volunteers WantedBlood Cancer
Study Of Chemotherapy For Children And Young Adults With High-Risk B-Cell Acute Lymphoblastic Leukemia (B-All)
Children and young adults up to age 25 with High-Risk B-cell acute lymphoblastic leukemia (B-ALL) sought for a study of an investigational drug in combination of chemotherapy based on individual disease characteristics to improve 5-year disease-free survival (DFS).
Healthy Volunteers WantedBlood Cancer
Study Of Chemotherapy Drug Combinations For Newly-Diagnosed Leukemia
Seeking children and young adults 31 years old or younger who have been newly diagnosed with standard risk B-cell Acute Lymphoblastic Leukemia (B-ALL), Down syndrome B ALL or localized B-cell Lymphoblastic Lymphoma (B-LLy) for a study of chemotherapy.
Healthy Volunteers WantedMetastatic Cancer
Study Of An Investigational Drug Combination For Renal Cell Cancer That Has Spread To The Bones
Seeing men and women whose renal cell cancer has spread to their bones for a study of an investigational drug combination to reduce pain.
Healthy Volunteers WantedKidney Cancer
Study Of An Investigational Drug Combination For Renal Cell Cancer That Has Spread To The Bones
Seeing men and women whose renal cell cancer has spread to their bones for a study of an investigational drug combination to reduce pain.
Healthy Volunteers WantedPancreatic Cancer
Study Of Early Detection And Prevention Of Pancreatic Cancer
Seeking men and women at risk for pancreatic cancer due to family or personal history willing to participate in an detection and prevention study.
Healthy Volunteers WantedLung Cancer
Study Of An Investigational Drug Combination For Initial Treatment For Metastatic Non-Small Cell Lung Cancer
Seeking men and women whose non-small cell lung cancer (NSCLC) has spread outside the lungs, and has a change in the gene called EGFR (epidermal growth factor receptor) and has not yet been treated for a study of an investigational drug combination.
Healthy Volunteers WantedAdvanced Cancer
Study Of An Investigational Drug Combination For Initial Treatment For Metastatic Non-Small Cell Lung Cancer
Seeking men and women whose non-small cell lung cancer (NSCLC) has spread outside the lungs, and has a change in the gene called EGFR (epidermal growth factor receptor) and has not yet been treated for a study of an investigational drug combination.
Healthy Volunteers WantedKidney Cancer
Study Of An Experimental Treatment Regimen For Newly Diagnosed Diffuse Anaplastic Wilms Tumor
Seeking people aged 30 and younger newly diagnosed with diffuse anaplastic Wilms tumor, a type of cancer that occurs in the kidney, for a study of experimental treatment regimen because no standard treatment regimen currently exists.
Healthy Volunteers WantedKidney Cancer
Study Of An Investigational Immunotherapy Drug Added To Usual Treatment For Urinary Tract Cancer
Seeking men and women aged 18 and older who have upper tract urothelial cancer for a study of whether adding an immunotherapy drug to the standard chemotherapy aid in preventing or delaying the cancer from growing.
Healthy Volunteers WantedLung Cancer
Study Of A Genomic Test To Assess Risk Of Lung Cancer
Seeking men and women who have had a lung nodule detected during imaging for collection of nasal swab and blood samples.
Healthy Volunteers WantedBlood Cancer
Study Of An Investigational Drug Combination For Acute Lymphoblastic Leukemia (All)
Seeking people aged 2-21 years who have been diagnosed with Philadelphia chromosome positive (Ph+) or ABL-class fusion positive Acute Lymphoblastic Leukemia (ALL) for a study of whether using a less toxic chemotherapy in combination with a drug called imatinib can keep the cancer from returning after treatment.
Healthy Volunteers WantedLung Cancer
Study To Develop A Treatment Guide For People Diagnosed With Metastatic Non-Small Cell Lung Cancer
Seeking men and women who have been diagnosed since January 1, 2020, with metastatic non-small cell lung cancer and have been or will be treated with immunotherapy, chemotherapy or a combination of the two for a study to develop a tool to help guide treatment decisions.
Healthy Volunteers WantedAdvanced Cancer
Study To Develop A Treatment Guide For People Diagnosed With Metastatic Non-Small Cell Lung Cancer
Seeking men and women who have been diagnosed since January 1, 2020, with metastatic non-small cell lung cancer and have been or will be treated with immunotherapy, chemotherapy or a combination of the two for a study to develop a tool to help guide treatment decisions.
Healthy Volunteers WantedBlood Cancer
Study Of An Investigational Drug Combination For Relapsed Or Refractory Diffuse Large B-Cell Lymphoma
Seeking men and women aged 18-65 years whose large B-Cell lymphoma has not responded or come back after treatment for a study of an investigational drug combination.
Healthy Volunteers WantedBlood Cancer
A Study To Determine If Participants With A Certain Cancer Can Stop Taking A Specific Medication (Aaml18p1)
Seeking male and female participants under the age of 25, who were diagnosed with Chronic Myeloid Leukemia before the age of 18, to determine if they can stop taking their TKI medication and remain in remission as well as if restarting TKI will re-achieve remission.
Healthy Volunteers WantedProstate Cancer
An International Registry For Men With Advanced Prostate Cancer (Ironman)
IRONMAN Registry aims to collect detailed information about the participants in the study at the time of enrollment and to follow their medical care to better understand what treatments work and where there are unmet needs in their treatment.
Healthy Volunteers WantedMetastatic Cancer
Study Of Use Of Tumor Genetic Testing To Guide Treatment For Meningioma
Seeking men and women whose meningioma (cancer of the brain covering) has gotten bigger or grew back after treatment for a study of whether cancer drugs targeting tumors based on their genetics is better, the same, or worse than the standard treatment for meningiomas.
Healthy Volunteers WantedMetastatic Cancer
Study Of An Investigational Drug For Metastatic Cancer That Has Spread To The Brain
Seeking men and women with metastatic cancer that has spread to their brain and progressed or grew back after treatment for a study of an investigational immunotherapy drug based on the gene type and source of the original cancer to prevent growth of metastatic tumors in the brain.
Healthy Volunteers WantedBlood Cancer
Study Of An Investigational Drug For Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma Or Non-Hodgkin Lymphoma
Seeking men and women who have a type of cancer that affects the B-cells (a type of white blood cells) in your blood that has not responded to, or who could not tolerate, the standard treatments normally given for this type of cancer for a study of an investigational drug.
Healthy Volunteers WantedBreast Cancer
Study Of An Investigational Drug For Early Stage Er+/Her2- Breast Cancer
Seeking people who have who have already taken endocrine therapy for two to five years for their early-stage ER+/HER2- breast cancer and have a higher-than-average risk for their cancer to return for a study to compare the investigational drug to standard hormone therapy.
Healthy Volunteers WantedLung Cancer
Study Of A Blood Test To Help Diagnose Lung Cancer
Seeking men and women who have been referred for follow-up imaging after a positive CT scan screen for lung cancer for a study of a blood test for early detection of lung cancer.
Healthy Volunteers WantedBreast Cancer
Study Of Artificial Intelligence Software To Predict Breast Cancer Risk In Women
Seeking women scheduled for a routine screening mammogram for a study comparing Artificial Intelligence (AI) software to standard guidelines for predicting breast cancer risk.
Healthy Volunteers WantedBladder Cancer
Study Of An Investigational Drug For Locally Advanced/Metastatic Cancer Of The Bladder, Urinary Tract, Or Solid Tumors
Seeking people aged 12 and older whose previous treatment has failed for a study of an investigational drug for locally advanced or metastatic cancer of the bladder, urinary tract, and other solid tumors
Healthy Volunteers WantedGynecological Cancer
Study Of An Investigational Drug For Platinum-Resistant Ovarian, Endometrial, Or Urothelial Cancer.
Seeking people with locally advanced or metastatic platinum-resistant ovarian, endometrial, or urothelial cancer for a study of an investigational drug.
Healthy Volunteers WantedOvarian Cancer
Study Of An Investigational Drug For Platinum-Resistant Ovarian, Endometrial, Or Urothelial Cancer.
Seeking people with locally advanced or metastatic platinum-resistant ovarian, endometrial, or urothelial cancer for a study of an investigational drug.
Healthy Volunteers WantedBlood Cancer
Study Of Covid Vaccination For People With Blood Cancer
Seeking men and women who have had stem cell transplant or cellular therapy for their blood cancer for a study of a COVID-19 vaccine.
Healthy Volunteers WantedLung Cancer
Lung Cancer Screening Study
Seeking UMass Memorial patients who are current or former smokers for a study about lung cancer screening
Healthy Volunteers WantedHead and Neck Cancer
Study Of An Investigational Treatment Combination For Stage 3 Or 4 Head And Neck Cancer
Seeking men and women with stage III or IV head and neck cancer for a study comparing two treatment options following tumor removal surgery.
Healthy Volunteers WantedAdvanced Cancer
Study Of An Investigational Treatment Combination For Stage 3 Or 4 Head And Neck Cancer
Seeking men and women with stage III or IV head and neck cancer for a study comparing two treatment options following tumor removal surgery.
Healthy Volunteers WantedLung Cancer
Study Comparing Targeted Drug Combinations For Advanced Non-Small Cell Lung Cancer
Seeking men and women with advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes for a study comparing targeted drug combinations
Healthy Volunteers WantedAdvanced Cancer
Study Comparing Targeted Drug Combinations For Advanced Non-Small Cell Lung Cancer
Seeking men and women with advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes for a study comparing targeted drug combinations
Healthy Volunteers WantedAdvanced Cancer
Study Of An Investigational Drug For Advanced Ovarian Cancer
Seeking women with ovarian cancer, fallopian tube or primary peritoneal cancer that has returned or has stopped responding to previous treatment for a study testing an investigational drug for tumors expressing a protein know as folate receptor alpha (FOLR1).
Healthy Volunteers WantedOvarian Cancer
Study Of An Investigational Drug For Advanced Ovarian Cancer
Seeking women with ovarian cancer, fallopian tube or primary peritoneal cancer that has returned or has stopped responding to previous treatment for a study testing an investigational drug for tumors expressing a protein know as folate receptor alpha (FOLR1).
Healthy Volunteers WantedAdvanced Cancer
Study Of An Investigational Drug Combination Before And Following Surgery For Melanoma
Seeking adults with Stage III or IV melanoma skin cancer that will be treated with surgery for a study of an investigational drug combination.
Healthy Volunteers WantedMelanoma
Study Of An Investigational Drug Combination Before And Following Surgery For Melanoma
Seeking adults with Stage III or IV melanoma skin cancer that will be treated with surgery for a study of an investigational drug combination.
Healthy Volunteers WantedBreast Cancer
Study Of An Investigational Drug For Triple Negative Breast Cancer
Seeking adults whose triple-negative breast cancer remained following surgery and pre-surgery treatment for a study of an investigational drug.
Healthy Volunteers WantedBladder Cancer
Study Of An Experimental Drug Combination To Prevent Cancer Recurrence For People With Bladder Cancer
Seeking men and women whose high-risk, non-muscle invasive bladder cancer has not spread to the muscle for a study comparing the standard Bacillus Calmette-Guerin (BCG) immunotherapy to an investigational chemotherapy drug combination.
Healthy Volunteers WantedLung Cancer
A Study Of A Combination Of Two Specific Drugs In Participants With Advanced Non-Small Cell Lung Cancer
Seeking men and women with a specific form of lung cancer to test if a combination of two specific drugs is beneficial.
Healthy Volunteers WantedGynecological Cancer
Study Of An Investigational Drug For Endometrial Cancer
Seeking women whose endometrial cancer has previously been treated with platinum-based chemotherapy and immunotherapy for a study of an investigational drug.
Healthy Volunteers WantedCancer Genetics
Study Of Skin From People With Autoimmune Skin Diseases Or Lymphoma
Seeking adults healthy volunteers and people with skin conditions such as skin lupus (cutaneous lupus erythematosus, CLE), scarring hair loss (primary cicatricial alopecias, PCAs), blistering conditions (pemphigus and pemphigoid conditions), scarring/fibrosis (scleroderma/morphea), and cancer (cutaneous T and B cell lymphomas) for a study collecting skin samples.
Healthy Volunteers WantedLung Cancer
Study Of An Investigational Drug Combination For Metastatic Non-Small Cell Lung Cancer
Seeking adults whose non-small Cell Lung Cancer has spread to other parts of their body (Metastatic) and who have not yet been treated for metastatic non-small cell lung cancer for a study of an investigational drug combination.
Healthy Volunteers WantedAdvanced Cancer
Study Of An Investigational Drug Combination For Metastatic Non-Small Cell Lung Cancer
Seeking adults whose non-small Cell Lung Cancer has spread to other parts of their body (Metastatic) and who have not yet been treated for metastatic non-small cell lung cancer for a study of an investigational drug combination.
Healthy Volunteers WantedLung Cancer
Study Of An Investigational Therapy For Small Cell Lung Cancer That Has Spread To Other Parts Of The Body
Seeking people with small cell lung cancer that has spread to other parts of the body (metastatic) for a study of whether adding radiation therapy to the usual treatment is better, worse or the same as the usual treatment alone following chemo-immunotherapy.
Healthy Volunteers WantedAdvanced Cancer
Study Of An Investigational Therapy For Small Cell Lung Cancer That Has Spread To Other Parts Of The Body
Seeking people with small cell lung cancer that has spread to other parts of the body (metastatic) for a study of whether adding radiation therapy to the usual treatment is better, worse or the same as the usual treatment alone following chemo-immunotherapy.
Healthy Volunteers WantedBreast Cancer
Study Of An Investigational Therapy For Early Stage Triple Negative Breast Cancer
Seeking adults with early stage triple negative breast cancer for a study comparing a shorter chemo-immunotherapy to the usual therapy.
Healthy Volunteers WantedBlood Cancer
Study Of An Investigational Drug For Acute Myeloid Leukemia
Seeking adults with Acute Myeloid Leukemia with an NPM1 mutation or KMT2A rearrangement for a study of an investigational drug to be used in combination with other chemotherapy drugs.
Healthy Volunteers WantedLung Cancer
Study Of An Investigational Therapy For Older Adults With Advanced Lung Cancer
Seeking adults aged 70 and older with stage IIIB-IV lung cancer for a study comparing immunotherapy and chemotherapy to immunotherapy alone.
Healthy Volunteers WantedAdvanced Cancer
Study Of An Investigational Therapy For Older Adults With Advanced Lung Cancer
Seeking adults aged 70 and older with stage IIIB-IV lung cancer for a study comparing immunotherapy and chemotherapy to immunotherapy alone.
Healthy Volunteers WantedLung Cancer
Study Of An Investigational Therapy For Locally Advanced Non-Small Cell Lung Cancer
Seeking adults with locally advanced non-small cell lung cancer for a study of adding radiation therapy to standard treatment for non-small cell lung cancer that cannot be treated by surgery (inoperable).
Healthy Volunteers WantedAdvanced Cancer
Study Of An Investigational Therapy For Locally Advanced Non-Small Cell Lung Cancer
Seeking adults with locally advanced non-small cell lung cancer for a study of adding radiation therapy to standard treatment for non-small cell lung cancer that cannot be treated by surgery (inoperable).
Healthy Volunteers WantedGynecological Cancer
Study Of An Investigational Drug For Newly Diagnosed Uterine Leiomyosarcoma
Seeking women with newly diagnosed early stage (I or II) uterine leiomyosarcoma for a study of whether taking an investigational drug following surgery is better than not taking the drug at preventing the cancer from returning.
Healthy Volunteers WantedGynecological Cancer
Study Of An Investigational Treatment Approach For Early-Stage Endometrial Cancer
Seeking people with early-stage endometrial cancer for a study comparing radiation therapy and surgery to surgery alone for early-stage endometrial cancer treatment.
Healthy Volunteers Wanted