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Overview

We pioneered the staging of primary erythroid progenitors by flow cytometry. This allows us to study minimally- perturbed progenitors directly within their physiological niche in vivo. We combine the staging of erythroid progenitors with new genome-wide technologies to investigate a number of inter-related areas:

cell fate decision

 


Activation of erythroid gene transcription: a cell fate decision orchestrated by the cell cycle

 

 

DNA Demethylation

 

 

Genome-wide loss of DNA methylation during erythroid differentiation

 

 

Systems biology

 

 

Systems Biology: Reverse engineering of the erythropoietic system

 

 

Stat5 signaling dynamics

 

 

 

 

Stat5 signaling dynamics: binary and graded signaling modalities