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Overview

Our laboratory explores the structural basis by which intermolecular interactions regulate biological function. Our current research projects include a potential cancer target (CtBP), a transcription factor (IRF5) implicated in autoimmune disease, and a model system for investigating intersubunit communication with nanosecond time resolution. In all cases, the functional properties depend upon regulation of subunit assembly by binding of ligands or phosphorylation. In the first two cases, development of inhibitors that disrupt oligomerization may lead to therapeutic agents useful in cancer and autoimmune disease!