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Biochemistry and Molecular Biotechnology
Research
Research
Overview
Cancer Target CtBP
Structural Regulation of IRFs
Time-resolved crystallographic analysis
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Royer Lab
Home
Research
Overview
Cancer Target CtBP
Structural Regulation of IRFs
Time-resolved crystallographic analysis
Lab Members
Laboratory Rotations
Publications
Join Us
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Royer Lab
Home
Research
Overview
Cancer Target CtBP
Structural Regulation of IRFs
Time-resolved crystallographic analysis
Lab Members
Laboratory Rotations
Publications
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Publications
Total:
15
results
NADH/NAD+ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2
January 08, 2022
Author(s):
Heidi Erlandsen,Anne M Jecrois,Jeffry C Nichols,James L Cole,William E Royer
Source:
FEBS letters
NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP)
February 01, 2021
Author(s):
Jeffry C Nichols,Celia A Schiffer,William E Royer
Source:
The Journal of biological chemistry
Cryo-EM structure of CtBP2 confirms tetrameric architecture
December 02, 2020
Author(s):
Anne M Jecrois,M Michael Dcona,Xiaoyan Deng,Dipankar Bandyopadhyay,Steven R Grossman,Celia A Schiffer,William E Royer
Source:
Structure (London, England : 1993)
Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures
March 06, 2020
Author(s):
Gordon J Lockbaum,Florian Leidner,William E Royer,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Acta crystallographica. Section D, Structural biology
Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities
May 01, 2019
Author(s):
M Michael Dcona,Priyadarshan K Damle,Francisco Zarate-Perez,Benjamin L Morris,Zaid Nawaz,Michael J Dennis,Xiaoyan Deng,Sudha Korwar,Sahib J Singh,Keith C Ellis,William E Royer,Dipankar Bandyopadhyay,C...
Source:
Molecular pharmacology
Assembly of human C-terminal binding protein (CtBP) into tetramers
April 28, 2018
Author(s):
Andrew G Bellesis,Anne M Jecrois,Janelle A Hayes,Celia A Schiffer,William E Royer
Source:
The Journal of biological chemistry
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity
April 29, 2017
Author(s):
Takahide Kouno,Tania V Silvas,Brendan J Hilbert,Shivender M D Shandilya,Markus F Bohn,Brian A Kelch,William E Royer,Mohan Somasundaran,Nese Kurt Yilmaz,Hiroshi Matsuo,Celia A Schiffer
Source:
Nature communications
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP)
May 09, 2016
Author(s):
Sudha Korwar,Benjamin L Morris,Hardik I Parikh,Robert A Coover,Tyler W Doughty,Ian M Love,Brendan J Hilbert,William E Royer,Glen E Kellogg,Steven R Grossman,Keith C Ellis
Source:
Bioorganic & medicinal chemistry
Structure-guided design of a high affinity inhibitor to human CtBP
January 31, 2015
Author(s):
Brendan J Hilbert,Benjamin L Morris,Keith C Ellis,Janet L Paulsen,Celia A Schiffer,Steven R Grossman,William E Royer
Source:
ACS chemical biology
Insight into the allosteric mechanism of Scapharca dimeric hemoglobin
October 31, 2014
Author(s):
Jennifer M Laine,Miguel Amat,Brittany R Morgan,William E Royer,Francesca Massi
Source:
Biochemistry
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design
March 25, 2014
Author(s):
Brendan J Hilbert,Steven R Grossman,Celia A Schiffer,William E Royer
Source:
FEBS letters
Resolution of structural heterogeneity in dynamic crystallography
May 23, 2013
Author(s):
Zhong Ren,Peter W Y Chan,Keith Moffat,Emil F Pai,William E Royer,Vukica Šrajer,Xiaojing Yang
Source:
Acta crystallographica. Section D, Biological crystallography
Tertiary and quaternary allostery in tetrameric hemoglobin from Scapharca inaequivalvis
March 06, 2013
Author(s):
Luca Ronda,Stefano Bettati,Eric R Henry,Tara Kashav,Jeffrey M Sanders,William E Royer,Andrea Mozzarelli
Source:
Biochemistry
Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures
December 16, 2011
Author(s):
Zhong Ren,Vukica Srajer,James E Knapp,William E Royer
Source:
Proceedings of the National Academy of Sciences of the United States of America
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding
November 19, 2010
Author(s):
Keith P Romano,Akbar Ali,William E Royer,Celia A Schiffer
Source:
Proceedings of the National Academy of Sciences of the United States of America
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Research
Overview
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Structural Regulation of IRFs
Time-resolved crystallographic analysis
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