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Lead Optimization

Lead Optimization

Molecular Docking – Screening a virtual library

*Incorporating Drug resistance
*Sequence Variation
*Substrate envelope 

Molecular Docking of a known (potential) ligand

Could be result of Screening or from literature

Protein Reagents

SAR from Screening data

Personalized (expert faculty chemist) analysis of screening data

Chemical Characterization of Small molecule

Chemical analysis of small molecule
NMR/MASS/HPLC

Synthesis of small ligands / inhibitors

De novo synthesis of specific compounds – dependent on the ease of synthesis  

 FOR MORE INFORMATION PLEASE CONTACT:

Akbar Ali, PhD
508-856-8873