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Chromatin Dynamics and Transcriptional Homeostasis

Transcriptionally active chromatin regions are characterized by the dynamic disruption and re-assembly of promoter proximal nucleosomes. Such chromatin dynamics are promoted by a combination of ATP-dependent chromatin remodeling enzymes (e.g. SWR1C, SWI/SNF, and INO80C), histone modifications (e.g. H3-K56Ac), and histone variants (e.g. H2A.Z). Our research uses a powerful combination of state-of-the-art chromatin biochemistry and genomic approaches in budding yeast to study the biological mechanisms that regulate both chromatin dynamics and transcriptional states. For more details (and some awesome animated movies) click the Research tab.