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Our Next Noon Seminar

 10/27/14 - Beth McCormick, Professor, Microbiology & Physiological Systems
Talk Title: The ABC's of Salmonella pathogenesis: A roadmap for therapeutic development


Chair's Message

In House Seminars

Molecular Medicine History

Retreats
2005 - 2008 - 2012

Michael Green Election to the National Academy of Sciences 2014

Nobel Prize Reception

Davis Royal Society Reception

Ambros Lasker Reception

Ambros Silverman Lecture


NEWS


 

Joel Richter receives $9.3 million over 5 years to establish one of three national Centers for Collaborative Research in Fragile X (NIH Article)

 

The Program in Molecular Medicine welcomes Professor Raffi Aroian and his laboratory colleagues to the Medical School! 

Raffi Aroian

Raffi’s national and international impact in the field of infectious diseases and parasitic disease is enormous and we are pleased that his laboratory will be continuing their work at UMASS MED.  A native of Worcester, MA, he earned his bachelor’s degree in physics at the Massachusetts Institute of Technology, and his PhD degree in biology from California Institute of Technology. Dr. Aroian is coming to UMMS from the University of California San Diego, where he was Professor, Section of Cell and Developmental Biology. After serving as a postdoctoral scholar with Bruce Alberts at UCSF, Dr Aroian began his career in biomedical research focused on the characterization of embryonic polarity genes in C. elegans.  Raffi’s studies rapidly led to interest in the basic biology of  infectious diseases using as models the free-living nematode, Caenorhabditis elegans, and the mouse parasitic nematode, Heligmosomoides polygyrus bakeri.  A major focus of his research examines pore-forming toxins (PFTs), which are the most common toxin made by pathogenic bacteria.  The laboratory studies a molecular genetic model of PFT pathogenesis, namely the interaction of C. elegans with the PFTs made by Bacillus thuringiensis (Bt). Raffi’s laboratory has discovered the intracellular pathways that enable C. elegans cells to counteract intoxication by PFTs, how these pathways are interconnected, and their protective functions during PFT attack.  The laboratory is also exploring new therapies for soil-transmitted helminths (STH), including hookworm, whipworm, and Ascaris, which are the most common infections in humans, affecting in excess of 2 billion people worlwide.  The Aroian laboratory has found that Crystal (Cry) proteins made by Bt are effective anthelmintics, and can cure two different worm infections in two different rodent models. Raffi is currently using the mouse parasite H. polygyrus to study basic and applied research questions of how to optimize Cry protein anthelmintic therapies and how to bring Cry proteins into human clinical trials.

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Victor Ambros named co-recipient of 2014 Gruber Genetics Prize

Full Article

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Heinrich Gottlinger, M.D. recipient of 2014 Avant-Garde Award

Full Article

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Michael Green elected to National Academy of Sciences

Full Article

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Jeremy Luban elected fellow of the American Academy of Microbiology

Full Article
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Victor Ambros named recipient of Israel's 2014 Wolf Prize.

Full Article
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Thomas Fazzio named one of the nations top scientists...

Full Article
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Foreign Policy names Luzuriaga a ‘Leading Global Thinker of 2013’ for HIV research

Full Article
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Dekker, Sullivan named fellows of prestigious scientific society
American Association for the Advancement of Science fellows announced

UMass Medical School scientists Job Dekker, PhD, and John L. Sullivan, MD, have been named Fellows of the American Association for the Advancement of Science (AAAS). Election as a Fellow is an honor bestowed upon AAAS members by their peers. (Full Article)

Roger Davis wins 2013 Steven C. Beering Award

 The Indiana University School of Medicine Steven C. Beering Award honors an internationally recognized individual for outstanding research contributions to the advancement of biomedical or clinical science. The Beering Award was established in 1983, honoring the important contributions Dr. Beering made to the Indiana University School of Medicine as its dean from 1974 to 1983. Dr. Beering was the youngest Dean appointed to the School of Medicine. He left the School to become the president of Purdue University, serving until his retirement on August 14th, 2000. The creation of the award was announced on June 24th, 1983 and the award is presented annually and consists of a medal and a prize of $25,000. Five of the past Beering Award recipients have become Nobel laureates, either before or after receipt of this award.

2013 Awardee: Roger J. Davis, PhD
The 2013 Steven C. Beering Award was presented to Roger J. Davis, PhD, Professor of Molecular Medicine and Biochemistry & Molecular Biology at University of Massachusetts Medical School on October 30, 2013.
To view the recorded Beering lectures, please visit here

Victor Ambros wins Keio Medical Science Prize

 The 18th Keio Medical Science Prize has been awarded to Victor R. Ambros, PhD, the Silverman Chair in Natural Science and professor of molecular medicine; and Shigekazu Nagata, PhD, professor of medical chemistry in the Graduate School of Medicine at Kyoto University.
Keio University annually awards the Keio Medical Science Prize “to recognize researchers who have made an outstanding contribution to the field of medicine or life sciences.”
It is the only prize of its kind awarded by a Japanese university, and six previous winners have gone on to win the Nobel Prize.
Keio Medical Science Prize Laureates will receive a certificate of merit, a medal and a monetary award at a ceremony and lecture in Tokyo on Nov. 27. - (Full article)

Katherine Luzuriaga named one of TIME magazine’s TIME 100

TIME’s annual list of the 100 most influential people in the world - link to article

Eduardo Torres Named 2013 Searle Scholar

FIFTEEN SEARLE SCHOLARS NAMED FOR 2013
April 3, 2013: Chicago, Illinois - Fifteen researchers in the chemical and biological sciences have been named as the 2013 Searle Scholars. Each will be awarded $300,000 to support his or her work during the next three years. (Full Article)
(Video Interview)

Researchers describe first 'functional HIV cure' in an infant

A team of researchers from UMMS, Johns Hopkins and the University of Mississippi have reported the first case of a so-called “functional cure” in an HIV-infected infant, which may help pave the way for eliminating HIV infection in children. (Full Article)

Bitter taste receptors in airway cells could help treat asthma attacks

UMMS research answers why substances that give some foods their bitter flavor also act to reverse the contraction of airway cells. (Full Article)

Two Molecular Medicine Scientists honored by National Academy of Inventors

January, 9 2013
Roger Davis and Craig Mello were recently named as 2012 Charter Fellows of the National Academy of Inventors (NAI). The NAI recognized 101 top scientists, innovators, and leaders from the academic world for their exceptional achievements "in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and the welfare of society."

The newly elected class of Fellows is made up of inventors and innovators from 56 prestigious research universities and non-profit research institutes across the U.S. and around the world. All are named inventors on patents issued by the United States Patent and Trademark Office (USPTO). Collectively, they hold an impressive number of U.S. patents—over 3,200. Dr Robert Brown and Dr John Ware from UMMS were also named as Charter Fellows.

Included among the Fellows are eight Nobel Laureates, 14 presidents of research universities and non-profit research institutes, 53 members of the National Academies (National Academy of Sciences, National Academy of Engineering, Institute of Medicine), 11 inductees of the National Inventors Hall of Fame, two Fellows of the Royal Society, five recipients of the National Medal of Technology and Innovation, four recipients of the National Medal of Science, and 31 AAAS Fellows, among other major awards and distinctions.

Roger Davis elected a Fellow of AAAS

In October, the American Association for the Advancement of Science Council elected Roger Davis, PhD, Howard Hughes Medical Institute Investigator, H. Arthur Smith Chair in Cancer Research and professor of molecular medicine and biochemistry & molecular pharmacology to the section on biological sciences. Fellows are nominated and selected by their peers for their meritorious efforts to advance science and its applications. The 701 fellows elected in 2012 will be recognized at the AAAS annual meeting in Boston in February.

 

Recent Molecular Medicine Publications

Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.

Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, Hartigan C, Corvera S.
J Biol Chem. 2014 Jun 27;289(26):18327-38. doi: 10.1074/jbc.M113.545798. Epub 2014 Apr 28.
PMID: 24778188 (Paper)

miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2.
Nelson C, Ambros V, Baehrecke EH.

Nelson C, Ambros V, Baehrecke EH.
Mol Cell. 2014 Oct 8. pii: S1097-2765(14)00718-7. doi: 10.1016/j.molcel.2014.09.011. [Epub ahead of print]
PMID: 25306920 (Paper)

NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbf?-SMMHC via activation of MEK/ERK axis.

Xue L, Pulikkan JA, Valk PJ, Castilla LH.
Blood. 2014 Jul 17;124(3):426-36. doi: 10.1182/blood-2013-12-541730. Epub 2014 Jun 3.
PMID: 24894773 (Paper)

Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila.

Amcheslavsky A, Song W, Li Q, Nie Y, Bragatto I, Ferrandon D, Perrimon N, Ip YT.
Cell Rep. 2014 Sep 24. pii: S2211-1247(14)00728-1. doi: 10.1016/j.celrep.2014.08.052. (Paper)

A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation.

Chun-Ting Chen, Heidi Hehnly, Qing Yu, Debby Farkas, Guoqiang Zheng, Sambra D. Redick, Hui-Fang Hung, Rajeev Samtani, Agata Jurczyk, Schahram Akbarian, Carol Wise, Andrew Jackson, Michael Bober, Yin Guo, Cecilia Lo, and Stephen Doxsey (Paper)

A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli.

Smith CL, Matheson TD, Sun X, Trombly DJ, Campeau E, Han X, Yates JR 3rd, and Kaufman PD (Paper) 

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis.

Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, Kim JK, Czech MP.
PLoS One. 2014 Sep 12;9(9):e107265. doi: 10.1371/journal.pone.0107265. eCollection 2014.
PMID: 25216251 (Paper)

A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia.

Ma L, Shan Y, Bai R, Xue L, Eide CA, Ou J, Zhu LJ, Hutchinson L, Cerny J, Khoury HJ, Sheng Z, Druker BJ, Li S, Green MR.
Sci Transl Med. 2014 Sep 3;6(252):252ra121. doi: 10.1126/scitranslmed.3009073.
PMID: 25186176 (Paper)

Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres.

Swygert SG, Manning BJ, Senapati S, Kaur P, Lindsay S, Demeler B, Peterson CL.
Nat Commun. 2014 Aug 28;5:4751. doi: 10.1038/ncomms5751.
PMID: 25163529 (Paper)

Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.

Amcheslavsky A, Nie Y, Li Q, He F, Tsuda L, Markstein M, Ip YT.
Development. 2014 Jul;141(13):2621-32. doi: 10.1242/dev.106237.
PMID: 24961799 (Paper)

The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing.

Zhang Z, Wang J, Schultz N, Zhang F, Parhad SS, Tu S, Vreven T, Zamore PD, Weng Z, Theurkauf WE.
Cell. 2014 Jun 5;157 (Paper)

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.

Ward J, Kanchagar C, Veksler-Lublinsky I, Lee RC, McGill MR, Jaeschke H, Curry SC, Ambros VR.
Proc Natl Acad Sci U S A. 2014 Aug 4. pii: 201412608. [Epub ahead of print]
PMID: 25092309 (Paper)

The Embryonic mir-35 Family of MicroRNAs Promotes Multiple Aspects of Fecundity in C. elegans.

McJunkin K, Ambros V.
G3 (Bethesda). 2014 Jul 21. pii: g3.114.011973. doi: 10.1534/g3.114.011973. [Epub ahead of print]
PMID: 25053708 (Paper)

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway.

Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ.
Cell Metab. 2014 Jul 15. (Paper)

Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease.

Hung CM, Calejman CM, Sanchez-Gurmaches J, Li H, Clish CB, Hettmer S, Wagers AJ, Guertin DA. (Paper)

A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection.

Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JC, Conte D, Gundersen-Rindal DE, Marshall WL, Yates J, Silverman N, Mello CC.   (Paper)

Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.

Amcheslavsky A, Nie Y, Li Q, He F, Tsuda L, Markstein M, Ip YT. (Paper)

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed.

Sanchez-Gurmaches J, Guertin DA.
Nat Commun. 2014 Jun 19;5:4099. doi: 10.1038/ncomms5099.
PMID: 24942009 (Paper)

Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.

Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, Shen Y, Czech MP, Aouadi M.
Cell Metab. 2014 Jan 7;19(1):162-71. doi: 10.1016/j.cmet.2013.11.017. Epub 2013 Dec 26.
PMID: 24374218(Paper)

Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity.

Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ.
Cell Rep. 2013 Aug 29;4(4):681-8. doi: 10.1016/j.celrep.2013.07.019. Epub 2013 Aug 15.
PMID: 23954791 [PubMed]
(Paper)

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells.

Kearns NA, Genga RM, Enuameh MS, Garber M, Wolfe SA, Maehr R.
Development. 2014 Jan;141(1):219-23. doi: 10.1242/dev.103341.
PMID: 24346702 [PubMed - indexed for MEDLINE]
(Paper)

EBV Latent Membrane Protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.

Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. J Virol. 2014 Jan 15. [Epub ahead of print]
PMID: 24429365 (Paper)

Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals.

Washietl S, Kellis M, Garber M.
Genome Res. 2014 Jan 15. [Epub ahead of print] PMID:24429298 (Paper)

Distinct functions for IFT140 and IFT20 in opsin transport.

Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ.
Cytoskeleton (Hoboken). 2014 Mar 12. doi: 10.1002/cm.21173. [Epub ahead of print] PMID: 24619649 [PubMed - as supplied by publisher]
(Paper)

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

Serra RW, Fang M, Park SM, Hutchinson L, Green MR.
Elife. 2014 Mar 12;3:e02313. doi: 10.7554/eLife.02313.
PMID: 24623306 [PubMed]
(Paper)

Arf4 is required for Mammalian development but dispensable for ciliary assembly.

Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ.
PLoS Genet. 2014 Feb 20;10(2):e1004170. doi: 10.1371/journal.pgen.1004170. eCollection 2014 Feb. PMID: 24586199 (Paper)

EBV Latent Membrane Protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.

Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. J Virol. 2014 Jan 15. (Paper)

Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits.

Watson E, Macneil LT, Ritter AD, Yilmaz LS, Rosebrock AP, Caudy AA, Walhout AJ.
Cell. 2014 Feb 13;156(4):759-70. doi: 10.1016/j.cell.2014.01.047. PMID: 24529378 (Paper)

Rab11 Endosomes Contribute to Mitotic Spindle Organization and Orientation.

Hehnly H, Doxsey S.
Dev Cell. 2014 Feb 18. pii: S1534-5807(14)00037-9. doi: 10.1016/j.devcel.2014.01.014. PMID: 24561039 (Paper)

Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans.

 Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC.
Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032.
PMID: 24360276 (Paper)

Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology.

Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD.
Nat Med. 2013 Nov;19(11):1473-7. doi: 10.1038/nm.3353. Epub 2013 Oct 20.
PMID: 24141422 [PubMed - indexed for MEDLINE] (Paper)

Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila.

Cheng W, Ip YT, Xu Z.
Gene. 2013 Dec 1;531(2):294-300. doi: 10.1016/j.gene.2013.08.080. Epub 2013 Sep 17.
PMID: 24055424 [PubMed - indexed for MEDLINE] (Paper)

Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway.

Vernia S, Cavanagh-Kyros J, Barrett T, Jung DY, Kim JK, Davis RJ.
Genes Dev. 2013 Nov 1;27(21):2345-55. doi: 10.1101/gad.223800.113.
PMID: 24186979 [PubMed - indexed for MEDLINE] (Paper)

Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans.

Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC.
Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032.
PMID: 24360276 [PubMed - in process]
(Paper)

The C. elegans CSR-1 Argonaute Pathway Counteracts Epigenetic Silencing to Promote Germline Gene Expression.

Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC. Dev Cell. 2013 Dec 18. pii: S1534-5807(13)00695-3. doi: 10.1016/j.devcel.2013.11.014. [Epub ahead of print] (Paper)

Using networks to measure similarity between genes: association index selection.

Fuxman Bass JI, Diallo A, Nelson J, Soto JM, Myers CL, Walhout AJ.
Nat Methods. 2013 Nov 26;10(12):1169-76. doi: 10.1038/nmeth.2728.
PMID: 24296474 Paper

Hdac6 regulates Tip60-p400 function in stem cells

Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG.
Elife. 2013 Dec 4;2(0):e01557. doi: 10.7554/eLife.01557.
PMID: 24302573 Paper

Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant.

Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Chun TW, Strain M, Richman D, Luzuriaga K.
N Engl J Med. 2013 Oct 23.
Paper

Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.

Malaby AW, van den Berg B, Lambright DG.
Proc Natl Acad Sci U S A. 2013 Aug 12. [Epub ahead of print]
PMID: 23940353 [PubMed - as supplied by publisher] Paper

Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis.

Fazly A, Jain C, Dehner AC, Issi L, Lilly EA, Ali A, Cao H, Fidel PL, P Rao R, Kaufman PD. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13594-9. Paper

Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules

Kearns NA, Genga RM, Ziller M, Kapinas K, Peters H, Brehm MA, Meissner A, Maehr R. Stem Cell Res. 2013 Jun 29;11(3):1003-1012. doi: 10.1016/j.scr.2013.06.007. [Epub ahead of print] Paper

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice.

Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP.
Proc Natl Acad Sci U S A. 2013 Apr 29. Paper

A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme.

Watanabe S, Radman-Livaja M, Rando OJ, Peterson CL.
Science. 2013 Apr 12;340(6129):195-9. Paper

CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.

Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D Jr, Mello CC.
Cell. 2012 Dec 21;151(7):1488-500. doi: 10.1016/j.cell.2012.11.023.
PMID: 23260138 [PubMed - indexed for MEDLINE]
Paper

Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism.

O'Connell O, Repik A, Reeves JD, Gonzalez-Perez MP, Quitadamo B, Anton ED, Duenas-Decamp M, Peters P, Lin R, Zolla-Pazner S, Corti D, Wallace A, Wang S, Kong XP, Lu S, Clapham PR.
J Virol. 2013 Jan;87(1):187-98. doi: 10.1128/JVI.01834-12. Epub 2012 Oct 10.
PMID: 23055568 [PubMed - indexed for MEDLINE]
Paper

HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency.

Santoni FA, Guerra J, Luban J. Retrovirology. 2012 Dec 20;9(1):111. [Epub ahead of print] Paper

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells.

Xie L, Gazin C, Park SM, Zhu LJ, Debily MA, Kittler EL, Zapp ML, Lapointe D, Gobeil S, Virbasius CM, Green MR.
PLoS Genet. 2012 Dec; Epub 2012 Dec 20. Paper

β3-adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation.

Roth Flach RJ, Matevossian A, Akie TE, Negrin KA, Paul MT, Czech MP. J Biol Chem. 2012 Dec 12 Paper

Translational control of mitochondrial energy production mediates neuron morphogenesis.

Oruganty-Das A, Ng T, Udagawa T, Goh EL, Richter JD. Cell Metab. 2012 Dec 12 Paper

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation.

Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. Science. 2012 Dec 6 Paper

Specific miRNA Stabilization by Gld2-Catalyzed Monoadenylation.

D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD.
Cell Rep. 2012 Nov 28. doi:pii: S2211-1247. Paper

Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation.

Wang M, Amano SU, Roth Flach RJ, Chawla A, Aouadi M, Czech MP.
Mol Cell Biol. 2012 Dec 3. [Epub ahead of print] Paper

An MBoC Favorite: Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.

Chen CT, Doxsey SJ.
Mol Biol Cell. 2012 Oct;23(19):3775. Paper

PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.

Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA.
Cell Metab. 2012 Sep 5;16(3):348-62. Paper

Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons.

Wang SZ, Ou J, Zhu LJ, Green MR.
Proc Natl Acad Sci U S A. 2012 Oct 22. Paper

An Unusual Two Step Control of CPEB Destruction by Pin1.

Nechama M, Lin CL, Richter JD. Paper
Mol Cell Biol. 2012 Oct 22.

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.

Hübner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ.
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12046-51. Paper

More

Molecular Medicine Awards

Victor Ambros, Ph.D.

Victor Ambros receives 2008 Lasker Prize
Also wins Keio Medical Science Award and the Wolf Prize.

Craig Mello, Ph.D.

Craig Mello receives 2006 Nobel Prize 

Roger Davis, PhD.

Roger Davis elected to Royal Society of London and EMBO

Michael Green, M.D., Ph.D.

Michael Green elected to National Academy of Sciences and EMBO

Jenn Benanti

 Jennifer Benanti receives 2011 Smith Family Award Program for Excellence in Biomedical Research

Eduardo Torres Eduardo Tores receives 2012 Smith Family Award Program for Excellence in Biomedical Research
Dave Guertin, Ph.D.

David Guertin receives 2010 PEW award

Picture of Katherine Luzuriaga  Katherine Luzuriaga named one of Time's most influential people
Picture of Silvia Corvera Silvia Corvera receives Endowed Chair in Diabetes Research
Thomas Fazzio, Ph.D.

Thomas Fazzio receives 2011 PEW award and the Presidential Early Career Awards for Scientists and Engineers

Jeremy Luban, M.D. Jeremy Luban receives Avant-Garde award

More

Welcome to Molecular Medicine...

Dr. Jeremy Luban joins the Program in Molecular Medicine Faculty

Drs. Amy Walker, Rene Maehr, Manuel Garber and Eduardo Torres.

Assistant Professor Michael Lee

Dr Juleen R. Zierath joins Molecular Medicine as Adjunct Professor
Juleen Zierath_thumb
Juleen R. Zierath is presently Professor of Clinical Integrative Physiology and Head of the Section of Integrative Physiology at the Department of Molecular Medicine and Surgery and the Department of Physiology and Pharmacology at Karolinska Institutet, Stockholm Sweden, where she is Director of the The Strategic Research Programme in Diabetes. She is also Professor of Integrative Physiology at University of Copenhagen, where she is a Scientific Director at the Marie Krogh Center for Metabolic Research, Copenhagen Denmark.