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Publication Spotlights

 

Congratulations on our team's most recent publication achievements!


SIMS training A recent publication on teaching palliative care to neurology residents at UMass in a simulated setting showcases the collaboration between palliative care and neurology in a recent article published in Neurology Journal titled Curriculum Innovations: Enhancing skills in serious illness communication in Neurology Residents Using Simulation: 

Read the article published by UMass Chan News, https://www.umassmed.edu/medicine/research/researchers-in-the-news/palliative-care-and-neurology-collaborate-to-develop-curriculum-that-aims-to-improve-serious-illness-communication-skills-for-neurology-residents/ 

February 2025 

Author(s) Bahadar Srichawla, Daksha Gopal, Majaz Moonis, of the February 2025 publication in Neurology International journal, titled, Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage.  

Author(s) Bahadar Srichawla, Vincent Kipkorir, Rakhee Lalla, of the February 2025 publication in Medicine journal, titled, Central-variant posterior reversable encehpalopathy syndrome in association with adrenal insufficiency: A case report. 

Author(s) Maria Garcia-Dominguez, Majaz Moonis, Vincent Kipkorir and Bahadar Srichawla, last author, of the February 2025 publication in Medicine journal, titled, The Clinical and Radiographic features of eastern equine encephalitis: A single-center retrospective case series. 

Kevin E. Houston, first author, of the February 2025 publication in Translational Vision Science and Technology journal, titled, A Single-Center Sham and Active Controlled Double-Blind Randomized Crossover Trial of the Magnetic Levator Prosthesis for Severe Blepharoptosis. 

Author, Eleonora D'Ambrosio, first author, of the February 2025 publication in Muscle and Nerve journal, Wiley Online Library titled, Comparision of Two Questionnaires for Sleep-Related Symptoms in Pediatric and Adult Patients With Myotonic Dystrophy Type 1.

January 2025 

Author, Bridgette Van Zundert, first author, of the January 2025 publication in SpencerNature journal of the Subcellular Biochemistry book series titled, Epigenetics in Neurodegenerative Diseases. 

Author(s), Mustafa Al Gburi, Maria Mazzola, Martina Absinta, Maria I Gaitan, Daniel S Reich, Sathish K Dundamadappa, Christopher C Hemond, of the January 2025 publication in Sage Journals titled, Paramagnetic rim lesion formation is predicted by the initial gadlinium-enhancing lesion diameter.  

Author(s), Elif O Dogan, Sean R Simonini, James Bouley, Alexandra Weiss, Robert H Brown Jr, Nils Henninger, of the January 2025 publication in Annals of Neurology journal titled, Genetic Ablationof Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis  

Access to the PubMed list of publications

Total: displaying 15 out of 50 results
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  • Incidence Trends and Risk of Recurrent Stroke of Cervical Artery Dissections in the United States Between 2005 and 2019

    Wednesday, April 02, 2025
    Author(s): Liqi Shu,Lukas Strelecky,Adam de Havenon,Thanh N Nguyen,Nils Henninger,Zafer Keser,Muhib Khan,James Ernest Siegler,Mary Penckofer,Setareh Salehi Omran,Thalia S Field,Lily Zhou,Han Xiao,Austin Jacobson,Eric D Goldstein,Christoph Stretz,Farhan Khan,Elizabeth Perelstein,Karen Furie,Shadi Yaghi
    Source: Neurology
    BACKGROUND AND OBJECTIVES: Cervical artery dissection (CeAD) is a common cause of acute ischemic stroke (AIS), especially in patients younger than 55 years, but data regarding trends and subsequent AIS risk after CeAD remain scarce. We aimed to determine national trends in CeAD admissions and examine post-CeAD risk of ischemic stroke.

  • Factors Associated With Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection

    Thursday, March 27, 2025
    Author(s): Daniel M Mandel,Liqi Shu,Christopher Chang,Naomi Jack,Christopher R Leon Guerrero,Nils Henninger,Jayachandra Muppa,Muhammad Affan,Omair Ul Haq Lodhi,Mirjam R Heldner,Kateryna Antonenko,David Seiffge,Marcel Arnold,Setareh Salehi Omran,Ross Crandall,Evan Lester,Diego Lopez Mena,Antonio Arauz,Ahmad Nehme,Marion Boulanger,Emmanuel Touze,Joao Andre Sousa,Joao Sargento-Freitas,Vasco Barata,Paulo Castro-Chaves,Maria Teresa Brito,Muhib Khan,Dania Mallick,Aaron Rothstein,Ossama Khazaal,Josefin E Kaufman,Stefan T Engelter,Christopher Traenka,Diana Aguiar de Sousa,Mafalda Soares,Sara Rosa,Lily W Zhou,Preet Gandhi,Thalia S Field,Steven Mancini,Issa Metanis,Ronen R Leker,Kelly Pan,Vishnu Dantu,Karl Baumgartner,Tina Burton,Regina von Rennenberg,Christian H Nolte,Richard Choi,Jason MacDonald,Reza Bavarsad Shahripour,Xiaofan Guo,Malik Ghannam,Mohammad Almajali,Edgar A Samaniego,Sebastian Sanchez,Bastien Rioux,Faycal Zine-Eddine,Alexandre Poppe,Ana Catarina Fonseca,Maria Fortuna Baptista,Diana Cruz,Michele Romoli,Giovanna De Marco,Marco Longoni,Zafer Keser,Kim Griffin,Lindsey Kuohn,Jennifer Frontera,Jordan Amar,James Giles,Marialuisa Zedde,Rosario Pascarella,Ilaria Grisendi,Hipolito Nzwalo,David S Liebeskind,Amir Molaie,Annie Cavalier,Wayneho Kam,Brian Mac Grory,Sami Al Kasab,Mohammad Anadani,Kimberly Kicielinski,Ali Eltatawy,Lina Chervak,Roberto Chulluncuy Rivas,Yasmin Aziz,Ekaterina Bakradze,Thanh Lam Tran,Marc Rodrigo Gisbert,Manuel Requena,Faddi Saleh Velez,Jorge Ortiz Gracia,Varsha Muddasani,Adam de Havenon,Venugopalan Y Vishnu,Sridhara Yaddanapudi,Latasha Adams,Abigail Browngoehl,Tamra Ranasinghe,Randy Dunston,Zachary Lynch,Mary Penckofer,James E Siegler,Silvia Mayer,Joshua Willey,Adeel Zubair,Yee Kuang Cheng,Richa Sharma,João Pedro Marto,Vítor Mendes Ferreira,Piers Klein,Thanh N Nguyen,Syed Daniyal Asad,Zoha Sarwat,Anvesh Balabhadra,Shivam Patel,Thais Secchi,Sheila Martins,Gabriel Mantovani,Young Dae Kim,Balaji Krishnaiah,Cheran Elangovan,Sivani Lingam,Abid Quereshi,Sebastian Fridman,Alonso Alvarado,Farid Khasiyev,Guillermo Linares,Marina Mannino,Valeria Terruso,Sofia Vassilopoulou,Vasileios Tentolouris-Piperas,Manuel Martinez Marino,Victor Carrasco Wall,Fransisca Indraswari,Sleiman El Jamal,Shilin Liu,Muhammad Alvi,Farman Ali,Mohammed Sarvath,Rami Z Morsi,Tareq Kass-Hout,Feina Shi,Jinhua Zhang,Dilraj Sokhi,Jamil Said,Newnex Mongare,Alexis Simpkins,Roberto Gomez,Shayak Sen,Mohammad Ghani,Marwa Elnazeir,Han Xiao,Narendra Kala,Farhan Khan,Christoph Stretz,Nahid Mohammadzadeh,Eric Goldstein,Karen Furie,Shadi Yaghi
    Source: Stroke
    CONCLUSIONS: In this post hoc analysis of the STOP-CAD study, several factors associated with subsequent ischemic stroke were identified among patients with CAD. Furthermore, we identified a potential benefit of anticoagulation in patients with CAD with occlusive dissection. These findings require validation by meta-analyses of prior studies to formulate optimal treatment strategies for specific high-risk CAD subgroups.

  • Characteristics and Medication Use Patterns of Pregnancies With COVID-19 Ending in Live-Birth in the Sentinel System

    Wednesday, March 26, 2025
    Author(s): Mayura Shinde,Austin Cosgrove,Jennifer G Lyons,Maria E Kempner,Jolene Mosley,David Cole,Emma Hoffman,Elizabeth Messenger-Jones,José J Hernández-Muñoz,Danijela Stojanovic,Benedict H W Wong,Yueqin Zhao,Leyla Sahin,Susan E Andrade,Sengwee Toh,Wei Hua
    Source: Pharmacoepidemiology and drug safety
    CONCLUSIONS: In this retrospective evaluation, selected medication utilization was higher post-COVID-19 among pregnancies with COVID-19, compared to those without COVID-19 and to non-pregnancy episodes with COVID-19. However, the low use of COVID-19-specific medications underscores the need for a safety evaluation of therapies used for COVID-19 management in the pregnant population.

  • In-Hospital Mortality Prediction among Intensive Care Unit Patients with Acute Ischemic Stroke: A Machine Learning Approach

    Tuesday, March 18, 2025
    Author(s): Jack A Cummins,Ben S Gerber,Mayuko Ito Fukunaga,Nils Henninger,Catarina I Kiefe,Feifan Liu
    Source: Health data science
    Background: Acute ischemic stroke is a leading cause of death in the United States. Identifying patients with stroke at high risk of mortality is crucial for timely intervention and optimal resource allocation. This study aims to develop and validate machine learning-based models to predict in-hospital mortality risk for intensive care unit (ICU) patients with acute ischemic stroke and identify important associated factors. Methods: Our data include 3,489 acute ischemic stroke admissions to the...

  • CNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial

    Tuesday, March 11, 2025
    Author(s): Writing Committee for the HEALEY ALS Platform Trial,James D Berry,Nicholas J Maragakis,Eric A Macklin,Lori B Chibnik,Melanie Quintana,Benjamin R Saville,Michelle A Detry,Matteo Vestrucci,Joseph Marion,Anna McGlothlin,Elijah W Stommel,Marianne Chase,Lindsay Pothier,Brittney A Harkey,Hong Yu,Alex Sherman,Jeremy Shefner,Meghan Hall,Gale Kittle,Suma Babu,Jinsy Andrews,Derek D'Agostino,Eric Tustison,Erica Scirocco,Elisa Giacomelli,Gustavo Alameda,Eduardo Locatelli,Doreen Ho,Adam Quick,Senda Ajroud-Driss,Jonathan Katz,Daragh Heitzman,Stanley H Appel,Sheetal Shroff,Kevin J Felice,Zachary Simmons,Timothy Miller,Nicholas Olney,Michael D Weiss,Stephen A Goutman,Joseph Americo Fernandes,Omar Jawdat,Margaret Ayo Owegi,Laura Foster,Tuan Vu,Hristelina Ilieva,Daniel S Newman,Ximena Arcila-Londono,Carlayne Jackson,Shafeeq Ladha,Terry Heiman-Patterson,James Caress,Andrea Swenson,Amanda Peltier,Richard Lewis,Dominic Fee,Matthew Elliott,Richard Bedlack,Edward J Kasarskis,Lauren Elman,Jeffrey Rosenfeld,David Walk,Courtney E McIlduff,Paul Twydell,Eufrosina Young,Kristin Johnson,Kourosh Rezania,Namita A Goyal,Jeffrey A Cohen,Michael Benatar,Vovanti Jones,Jonathan Glass,Jaimin Shah,Said R Beydoun,James P Wymer,Lindsay Zilliox,Shakti Nayar,Gary L Pattee,Jennifer Martinez-Thompson,Austin Rynders,Jacob Evan,Jeremy Evan,Alan Hartford,Marjan Sepassi,Karen S Ho,Robert Glanzman,Benjamin Greenberg,Michael T Hotchkin,Sabrina Paganoni,Merit E Cudkowicz,HEALEY ALS Platform Trial Study Group
    Source: JAMA
    CONCLUSIONS AND RELEVANCE: No benefit of CNM-Au8 on ALS disease progression was observed at 24 weeks.

  • Pridopidine in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial

    Tuesday, March 11, 2025
    Author(s): Writing Committee for the HEALEY ALS Platform Trial,Jeremy M Shefner,Björn Oskarsson,Eric A Macklin,Lori B Chibnik,Melanie Quintana,Benjamin R Saville,Michelle A Detry,Matteo Vestrucci,Joe Marion,Anna McGlothlin,Terry Heiman-Patterson,Marianne Chase,Lindsay Pothier,Brittney A Harkey,Hong Yu,Alexander V Sherman,Meghan Hall,Gale Kittle,James D Berry,Suma Babu,Jinsy Andrews,Derek D'Agostino,Eric Tustison,Erica Scirocco,Elisa Giacomelli,Gustavo Alameda,Eduardo Locatelli,Doreen Ho,Adam Quick,Senda Ajroud-Driss,Jonathan Katz,Daragh Heitzman,Stanley H Appel,Sheetal Shroff,Kevin Felice,Nicholas J Maragakis,Zachary Simmons,Timothy M Miller,Nicholas Olney,Michael D Weiss,Stephen A Goutman,Joseph Americo Fernandes,Omar Jawdat,Margaret Ayo Owegi,Laura A Foster,Tuan Vu,Hristelina Ilieva,Daniel S Newman,Ximena Arcila-Londono,Carlayne E Jackson,Shafeeq Ladha,James B Caress,Andrea Swenson,Amanda Peltier,Richard A Lewis,Dominic Fee,Matthew Elliott,Richard Bedlack,Edward J Kasarskis,Lauren Elman,Jeffrey Rosenfeld,David Walk,Courtney McIlduff,Paul Twydell,Eufrosina Young,Kristin Johnson,Kourosh Rezania,Namita A Goyal,Jeffrey A Cohen,Michael Benatar,Vovanti Jones,Jaimin Shah,Said R Beydoun,James P Wymer,Lindsay Zilliox,Shakti Nayar,Gary L Pattee,Jennifer Martinez-Thompson,Melanie L Leitner,Kelly Chen,Y Paul Goldberg,Yael Cohen,Michal Geva,Michael R Hayden,Sabrina Paganoni,Merit E Cudkowicz,HEALEY ALS Platform Trial Study Group
    Source: JAMA
    CONCLUSIONS AND RELEVANCE: In this 24-week study, pridopidine did not impact the progression of ALS.

  • Verdiperstat in Amyotrophic Lateral Sclerosis: Results From the Randomized HEALEY ALS Platform Trial

    Tuesday, March 11, 2025
    Author(s): Writing Committee for the HEALEY ALS Platform Trial,Jinsy Andrews,Sabrina Paganoni,Eric A Macklin,Lori B Chibnik,Melanie Quintana,Benjamin R Saville,Michelle A Detry,Matteo Vestrucci,Joseph Marion,Anna McGlothlin,Eufrosina Young,Marianne Chase,Lindsay Pothier,Brittney Harkey,Hong Yu,Alex Sherman,Jeremy Shefner,Meghan Hall,Gale Kittle,Mariah R Connolly,James D Berry,Derek D'Agostino,Eric Tustison,Elisa Giacomelli,Erica Scirocco,Gustavo Alameda,Eduardo Locatelli,Doreen Ho,Adam Quick,Daragh Heitzman,Senda Ajroud-Driss,Stanley H Appel,Sheetal Shroff,Jonathan Katz,Kevin Felice,Nicholas J Maragakis,Zachary Simmons,Stephen A Goutman,Nicholas Olney,Timothy Miller,Joseph Americo Fernandes,Hristelina Ilieva,Omar Jawdat,Michael D Weiss,Laura Foster,Tuan Vu,Shafeeq Ladha,Margaret Ayo Owegi,Daniel S Newman,Ximena Arcila-Londono,Carlayne E Jackson,Andrea Swenson,Terry Heiman-Patterson,James Caress,Dominic Fee,Amanda Peltier,Richard Lewis,Jeffrey Rosenfeld,David Walk,Kristin Johnson,Matthew Elliott,Edward J Kasarskis,Seward Rutkove,Courtney E McIlduff,Richard Bedlack,Lauren Elman,Namita A Goyal,Kourosh Rezania,Paul Twydell,Michael Benatar,Jonathan Glass,Jeffrey A Cohen,Vovanti Jones,Lindsay Zilliox,James P Wymer,Said R Beydoun,Jaimin Shah,Gary L Pattee,Jennifer Martinez-Thompson,Shakti Nayar,Volkan Granit,Mary Donohue,Katheryn Grossman,Daniel J Campbell,Irfan A Qureshi,Merit E Cudkowicz,Suma Babu,HEALEY ALS Platform Trial Study Group
    Source: JAMA neurology
    CONCLUSIONS AND RELEVANCE: Results demonstrate that treatment with verdiperstat was unlikely to alter disease progression in ALS.

  • Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

    Thursday, March 06, 2025
    Author(s): Seung Hoan Choi,Sean J Jurgens,Ling Xiao,Matthew C Hill,Christopher M Haggerty,Garðar Sveinbjörnsson,Valerie N Morrill,Nicholas A Marston,Lu-Chen Weng,James P Pirruccello,David O Arnar,Daniel Fannar Gudbjartsson,Helene Mantineo,Aenne S von Falkenhausen,Andrea Natale,Arnljot Tveit,Bastiaan Geelhoed,Carolina Roselli,David R Van Wagoner,Dawood Darbar,Doreen Haase,Elsayed Z Soliman,Giovanni E Davogustto,Goo Jun,Hugh Calkins,Jeffrey L Anderson,Jennifer A Brody,Jennifer L Halford,John Barnard,John E Hokanson,Jonathan D Smith,Joshua C Bis,Kendra Young,Linda S B Johnson,Lorenz Risch,Lorne J Gula,Lydia Coulter Kwee,Mark D Chaffin,Michael Kühne,Michael Preuss,Namrata Gupta,Navid A Nafissi,Nicholas L Smith,Peter M Nilsson,Pim van der Harst,Quinn S Wells,Renae L Judy,Renate B Schnabel,Renee Johnson,Roelof A J Smit,Stacey Gabriel,Stacey Knight,Tetsushi Furukawa,Thomas W Blackwell,Victor Nauffal,Xin Wang,Yuan-I Min,Zachary T Yoneda,Zachary W M Laksman,Connie R Bezzina,Alvaro Alonso,Bruce M Psaty,Christine M Albert,Dan E Arking,Dan M Roden,Daniel I Chasman,Daniel J Rader,David Conen,David D McManus,Diane Fatkin,Emelia J Benjamin,Eric Boerwinkle,Gregory M Marcus,Ingrid E Christophersen,J Gustav Smith,Jason D Roberts,Laura M Raffield,M Benjamin Shoemaker,Michael H Cho,Michael J Cutler,Michiel Rienstra,Mina K Chung,Morten S Olesen,Moritz F Sinner,Nona Sotoodehnia,Paulus Kirchhof,Ruth J F Loos,Saman Nazarian,Sanghamitra Mohanty,Scott M Damrauer,Stefan Kaab,Susan R Heckbert,Susan Redline,Svati H Shah,Toshihiro Tanaka,Yusuke Ebana,Regeneron Genetics Center,NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,Hilma Holm,Kari Stefansson,Christian T Ruff,Marc S Sabatine,Kathryn L Lunetta,Steven A Lubitz,Patrick T Ellinor
    Source: Nature genetics
    Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls. In burden tests of rare coding variation, we identified novel associations between AF and the genes MYBPC3, LMNA, PKP2, FAM189A2 and KDM5B. We further identified associations between AF and rare structural variants owing to deletions in CTNNA3 and duplications...

  • Minimal clinical impact of embolization to new territory on outcomes in medium vessel occlusion strokes treated with mechanical thrombectomy: a retrospective multicenter study

    Wednesday, March 05, 2025
    Author(s): Hamza Adel Salim,Vivek Yedavalli,Dhairya A Lakhani,Fathi Milhem,Basel Musmar,Nimer Adeeb,Tobias D Faizy,Motaz Daraghma,Kareem El Naamani,Nils Henninger,Sri Hari Sundararajan,Anna Luisa Kuhn,Jane Khalife,Sherief Ghozy,Luca Scarcia,Inayat Grewal,Leonard Ll Yeo,Benjamin Yq Tan,Robert W Regenhardt,Jeremy Josef Heit,Nicole M Cancelliere,Aymeric Rouchaud,Jens Fiehler,Sunil A Sheth,Ajit S Puri,Christian Dyzmann,Marco Colasurdo,Leonardo Renieri,João Pedro Filipe,Pablo Harker,Răzvan Alexandru Radu,Mohamad Abdalkader,Piers Klein,Thomas R Marotta,Julian Spears,Takahiro Ota,Ashkan Mowla,Pascal Jabbour,Arundhati Biswas,Frédéric Clarençon,James E Siegler,Thanh N Nguyen,Ricardo Varela,Amanda Baker,Muhammed Amir Essibayi,David Altschul,Nestor Gonzalez,Markus A Möhlenbruch,Vincent Costalat,Benjamin Gory,Christian Paul Stracke,Constantin Hecker,Gaultier Marnat,Hamza Shaikh,Christoph J Griessenauer,David S Liebeskind,Alessandro Pedicelli,Andrea Maria Alexandre,Illario Tancredi,Erwah Kalsoum,Boris Lubicz,Aman B Patel,Vitor Mendes Pereira,Max Wintermark,Adrien Guenego,Adam A Dmytriw,MAD MT Investigators
    Source: Journal of neurointerventional surgery
    CONCLUSIONS: ENT during MT for MeVO stroke occurs infrequently and does not significantly affect the clinical outcomes. These findings suggest ENT risk should not deter clinicians from performing MT in patients with MeVO. Further prospective studies are needed to validate these results.

  • Psychosocial Burden and Suicidality in Epilepsy: A Public Health Concern

    Monday, March 03, 2025
    Author(s): Elaine T Kiriakopoulos,Felicia Chu,Jay Salpekar,Gaston Baslet,Gena Ghearing,Hamada Altalib,Martha Sajatovic
    Source: Epilepsy currents
    The increased risk for psychosocial burden and suicidality in people with epilepsy compared to the general population is a well-established global public health concern. Suicidality risk is also increased in patients with functional seizures. The timely identification of patients at highest risk for psychosocial burden and self-harm is vital. This can pose a significant challenge for multidisciplinary clinicians caring for people with epilepsy. Early identification of social stressors and...

  • Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage

    Tuesday, February 25, 2025
    Author(s): Bahadar S Srichawla,Daksha Gopal,Majaz Moonis
    Source: Neurology international
    Background/Objectives: Intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) are severe forms of stroke with high morbidity and mortality rates. HMG-CoA reductase inhibitors, commonly referred to as statins, known for their lipid-lowering abilities, also possess pleiotropic properties, including anti-inflammatory and neuroprotective effects. We aimed to evaluate the impact of statin therapy on the functional outcomes and survival in patients with ICH and SAH. Methods: This...

  • Central-variant posterior reversible encephalopathy syndrome in association with adrenal insufficiency: A case report

    Monday, February 24, 2025
    Author(s): Bahadar S Srichawla,Vincent Kipkorir,Rakhee Lalla
    Source: Medicine
    RATIONALE: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic condition often linked to hypertension, eclampsia, or renal failure. PRES typically presenting with seizures, headaches, visual disturbances, and altered mental status. A rarer form, the central variant of PRES, involves atypical radiologic findings such as edema in central brain structures. PRES has not been previously associated with adrenal insufficiency, making this case novel and significant.

  • The clinical and radiographic features of eastern equine encephalitis: A single-center retrospective case series

    Wednesday, February 19, 2025
    Author(s): Maria A Garcia-Dominguez,Majaz Moonis,Vincent Kipkorir,Bahadar S Srichawla
    Source: Medicine
    RATIONALE: This case series aims to describe the clinical and radiographic findings associated with eastern equine encephalitis (EEE) virus.

  • Intravenous Thrombolysis in Cervical Artery Dissection-Related Stroke: A Nationwide Study

    Wednesday, February 19, 2025
    Author(s): Liqi Shu,Elizabeth Lee,Thalia S Field,Xiaofan Guo,Nils Henninger,Zafer Keser,Muhib Khan,Eva A Mistry,Thanh N Nguyen,James E Siegler,Lukas Strelecky,Daniel M Mandel,Christoph Stretz,Karen L Furie,Shadi Yaghi
    Source: Journal of the American Heart Association
    CONCLUSIONS: IVT improves the likelihood of home discharge in patients with CeAD-AIS without increasing the risk of inpatient death or intracerebral hemorrhage.

  • Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial

    Monday, February 17, 2025
    Author(s): Sabrina Paganoni,Christina N Fournier,Eric A Macklin,Lori B Chibnik,Melanie Quintana,Benjamin R Saville,Michelle A Detry,Matteo Vestrucci,Joe Marion,Anna McGlothlin,Senda Ajroud-Driss,Marianne Chase,Lindsay Pothier,Brittney A Harkey,Hong Yu,Alexander V Sherman,Jeremy M Shefner,Meghan Hall,Gale Kittle,James D Berry,Suma Babu,Jinsy Andrews,Derek Dagostino,Eric Tustison,Elisa Giacomelli,Erica Scirocco,Gustavo Alameda,Eduardo Locatelli,Doreen Ho,Adam Quick,Jonathan Katz,Daragh Heitzman,Stanley H Appel,Sheetal Shroff,Kevin Felice,Nicholas J Maragakis,Zachary Simmons,Timothy M Miller,Nicholas Olney,Michael D Weiss,Stephen A Goutman,Joseph Americo Fernandes,Omar Jawdat,Margaret Ayo Owegi,Laura A Foster,Tuan Vu,Hristelina Ilieva,Daniel S Newman,Ximena Arcila-Londono,Carlayne E Jackson,Shafeeq Ladha,Terry Heiman-Patterson,James B Caress,Andrea Swenson,Amanda Peltier,Richard Lewis,Dominic Fee,Matthew Elliott,Richard Bedlack,Edward J Kasarskis,Lauren Elman,Jeffrey Rosenfeld,David Walk,Courtney McIlduff,Paul Twydell,Eufrosina Young,Kristin Johnson,Kourosh Rezania,Namita A Goyal,Jeffrey A Cohen,Michael Benatar,Vovanti Jones,Jonathan Glass,Jaimin Shah,Said R Beydoun,James P Wymer,Lindsay Zilliox,Shakti Nayar,Gary L Pattee,Jennifer Martinez-Thompson,Brittany Harvey,Shital Patel,Paul Mahoney,Petra W Duda,Merit E Cudkowicz,HEALEY ALS Platform Trial Study Group
    Source: JAMA network open
    CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of zilucoplan in ALS, treatment did not alter disease progression. The adaptive platform design of the HEALEY ALS Platform Trial made it possible to test a new investigational product with efficient use of time and resources.
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