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Global collaboration among scientists, which was really made possible by ALS Ice Bucket Challenge donations, led to this important discovery,

- John Landers of the University of Massachusetts Medical School

Research Strategy

The recent development of exon capture and short-read sequencing technologies now allows screening of cohorts for rare variants at a genome-wide scale in an economically feasible way. Our laboratory is focused on adopting the exon capture and short-read sequencing approach, in combination with bioinformatics analysis, to identify novel causative genes for FALS. It is our hope that by understanding the genetic causes of ALS, we will facilitate our understanding of all forms of ALS, as well as assisting in the development of diagnostics and therapies to extend the lifespan of ALS patients. 

VIDEO | JUL 27, 2016

UMMS-led discovery of ALS gene funded by Ice Bucket Challenge


The discovery of an ALS gene by UMass Medical School scientist John Landers, PhD, and a large, international research team, funded by the viral Ice Bucket Challenge campaign, is garnering headlines around the globe.


ARTICLE | JUL 25, 2016

New gene variants present in 3 percent of all ALS patients


Variations in a gene with multiple functions in neurons are present in approximately 3 percent of all cases of ALS in North American and European populations, both sporadic and familial...


ARTICLE | JUL 27, 2016

Frates Family ‘Grateful’ For Donations That Led To ALS Gene Discovery


It was more than two years ago that Dr. Landers wanted to become part of what’s known as Project Mine for ALS research but was told the funding wasn’t available. The Ice Bucket Challenge changed everything.


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