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A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry.
Hayes JA1, Hilbert BJ2, Gaubitz C2, Stone NP2, Kelch BA3.
J Biol Chem. 2020 Feb 3. pii: jbc.RA119.012224. doi: 10.1074/jbc.RA119.012224. [Epub ahead of print]

Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure.
Stone NP, Demo G, Agnello E, Kelch BA.
Nat Commun. 2019 Oct 2;10(1):4471. doi: 10.1038/s41467-019-12341-z.

Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
Paul Solomon Devakumar LJ, Gaubitz C, Lundblad V, Kelch BA, Kubota T.
Nucleic Acids Res. 2019 May 22. pii: gkz441. doi: 10.1093/nar/gkz441.

Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure.
Stone, NP, Demo G, Agnello E, Kelch BA.
biorXiv, 2018 Nov 19; doi: https://doi.org/10.1101/473264

A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein.
Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA.
Structure. 2018 Jul 3;26(7):936-947.e3.

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.
Silvas TV, Hou S, Myint W, Nalivaika E, Somasundaran M, Kelch BA, Matsuo H, Kurt Yilmaz N, Schiffer CA.
Sci Rep. 2018 May 14;8(1):7511.

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Kouno T, Silvas TV, Hilbert BJ, Shandilya SMD, Bohn MF, Kelch BA, Royer WE, Somasundaran M, Kurt Yilmaz N, Matsuo H, Schiffer CA
Nat Commun. 2017

The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.
Hilbert BJ, Hayes JA, Stone NP, Xu RG, Kelch BA
Nucleic Acids Res. 2017

Review: The lord of the rings: Structure and mechanism of the sliding clamp loader.
Kelch BA
Biopolymers. 2016

A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
Duffy CM, Hilbert BJ, Kelch BA
J Mol Biol. 2016

Structure and mechanism of the ATPase that powers viral genome packaging.
Hilbert BJ, Hayes JA, Stone NP, Duffy CM, Sankaran B, Kelch BA
Proc Natl Acad Sci U S A. 2015

The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Bohn MF, Shandilya SMD, Silvas TV, Nalivaika EA, Kouno T, Kelch BA, Ryder SP, Kurt-Yilmaz N, Somasundaran M, Schiffer CA
Structure. 2015

A structural role for the PHP domain in E. coli DNA polymerase III.
Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH
BMC Struct Biol. 2013

Functional modulation of a protein folding landscape via side-chain distortion.
Kelch BA, Salimi NL, Agard DA
Proc Natl Acad Sci U S A. 2012

Clamp loader ATPases and the evolution of DNA replication machinery.
Kelch BA, Makino DL, O'Donnell M, Kuriyan J
BMC Biol. 2012

How a DNA polymerase clamp loader opens a sliding clamp.
Kelch BA, Makino DL, O'Donnell M, Kuriyan J
Science. 2011

The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Simonetta KR, Kazmirski SL, Goedken ER, Cantor AJ, Kelch BA, McNally R, Seyedin SN, Makino DL, O'Donnell M, Kuriyan J
Cell. 2009

Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability.
Kelch BA, Agard DA
J Mol Biol. 2007

Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior.
Kelch BA, Eagen KP, Erciyas FP, Humphris EL, Thomason AR, Mitsuiki S, Agard DA
J Mol Biol. 2007

Mediation by indole analogues of electron transfer during oxygen activation in variants of Escherichia coli ribonucleotide reductase R2 lacking the electron-shuttling tryptophan 48.
Saleh L, Kelch BA, Pathickal BA, Baldwin J, Ley BA, Bollinger JM
Biochemistry. 2004

The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain.
Fuhrmann CN, Kelch BA, Ota N, Agard DA
J Mol Biol. 2004