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Cardiovascular and Surgical Models Core

Our core provides state-of-the-art phenotyping of cardiovascular system in mouse models of metabolic disease and an easily accessible cardiovascular disease model pipeline. Our unique services enhance whole body metabolic characterization given that cardiovascular complications represent the major source of morbidity and mortality in obesity and diabetes. We also offer sophisticated surgical and disease models that encompass major cardiovascular complications of diabetes and NASH (Nonalcoholic Steatohepatitis): peripheral vascular disease, coronary atherosclerosis, heart failure and liver .

Our services include:

  • 2-D, 3D and 4D echocardiography in lightly-anesthetized mice to non-invasively assess cardiac structure and function using state-of-the-art high-frequency, high-resolution in vivo digital imaging platform (VisualSonics Vevo 3100)
  • Non-invasive analysis of diastolic function and strain analysis (radial, circumferential, and longitudinal) using pulsed wave color Doppler mode
  • Non-invasive measurement of blood pressure, ECG, and heart rate
  • In vivo assessment of endothelial function using Danish Myo Technology
  • Quantification of aortic atherosclerosis via in vivo ultrasound and ex vivo en face and aortic root Oil Red O staining
  • Abdominal Aortic Aneurysm (AAA) via in vivo ultrasound
  • Hind Limb Ischemia (HLI) disease models to investigate peripheral vascular disease (PVD) using Moore Instruments Laser Speckle Contrast Imager
  • Coronary Artery Ligation (CAL) model to investigate chronic myocardial infarction
  • Transverse Aortic Constriction (TAC) model to investigate pressure-overload hypertrophy, congestive heart failure, and aortic stenosis
  • Left Anterior Descending Coronary Artery Ligation (LAD) Models to study both acute cardiac ischemia/reperfusion injury and chronic cardiac ischemia (MI)
  • Parabiosis model surgically connecting two animals to observe secreted factor in one animal’s impact on the physiology of a second animal through their shared circulatory system.
  • Wire Myography
  • Plus, many other research models available, please inquire for your specific needs. Cardiovascular and Surgical Models Core 
Director

Timothy P. Fitzgibbons MD, PhD
Division of Cardiovascular Medicine
Worcester MA, 01655
(508) 856-3905
timothy.fitzgibbons@umassmemorial.org
Cardiovascular and Surgical Models 

Fitzgibbons

Associate Director

Mark Kelly, LAT
Cardiovascular and Surgical Models Core 
(508) 856-3905
mark.kelly@umassmed.edu

Address:

UMas Chan Medical School
Biotech Two, Suite 100
373 Plantation Street
Worcester, MA 01605

 
Overview Mice2