Campus alert status is yellow: For the latest campus alert status, news and resources, visit

Search Close Search
Page Menu

Metallic Implant Surface Modifications

Strategies to reduce periprosthetic infections and enhance implant osteointegration

Read our publications:

Ananta Ghimire and Jie Song. Anti-periprosthetic infection strategies: from implant surface topographical engineering to smart drug-releasing coatings. ACS Appl Mater Interfaces. 2021, 13(18):20921–20937. View Publication.

Ben Zhang, Jordan D. Skelly, Benjamin Braun, David C. Ayers and Jie Song. Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing Staphylococcus aureus periprosthetic infections ACS Appl Bio Mater 2020, 3(9), 5896-5904. View Publication

Ananta Ghimire, Jordan D. Skelly and Jie Song. Micrococcal-nuclease-triggered on-demand release of vancomycin from Intramedullary implant coating eradicates Staphylococcus aureus infection in mouse femoral canals. ACS Central Science 2019, Dec 10; 5(12): 1929–1936.

Zhang B, Braun B, Skelly J, Ayers D, Song J. Significant Suppression of S. aureus Colonization on Intramedullary Ti6Al4V Implants Surface-grafted with Vancomycin-bearing Polymer Brushes. ACS Appl Mater Interfaces. 2019 Jul 17; 11(32):28641-28647. PMID: 31313901.
View in: PubMed
Liu P, Song J. Well-controlled ATRP of 2-(2-(2-Azidoethyoxy)ethoxy)ethyl Methacrylate for High-density Click Functionalization of Polymers and Metallic Substrates. J Polym Sci A Polym Chem. 2016 May 01; 54(9):1268-1277. PMID: 27616816.
View in: PubMed
Liu P, Domingue E, Ayers DC, Song J. Modification of Ti6Al4V substrates with well-defined zwitterionic polysulfobetaine brushes for improved surface mineralization. ACS Appl Mater Interfaces. 2014 May 28; 6(10):7141-52. PMID: 24828749.
View in: PubMed
Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95. PMID: 21651998.
View in: PubMed