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Throughout history, tuberculosis (TB) has taken a remarkable toll on human health. Even today, more than 50 years after the advent of antibiotic therapy, this infection kills millions every year. The resilience of this disease in the face of modern treatment is largely a result of the unusual biology of the causative agent, Mycobacterium tuberculosis. Our lab is focused on understanding the physiology of the mycobacterial cell, the interactions between host and pathogen, and how these fundamental biological processes influence pathogenesis and antibiotic efficacy.

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