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Publications

All Rhind Lab publications can be found on MyNCBI

Fission yeast cells grow approximately exponentially.
Pickering M, Hollis LN, D'Souza E, Rhind N.
Cell Cycle. 2019 Apr;18(8):869-879. Epub 2019 Apr 6.

Transcriptome-wide Interrogation of the Functional Intronome by Spliceosome Profiling.
Chen W, Moore J, Ozadam H, Shulha HP, Rhind N, Weng Z, Moore MJ.
Cell. 2018 May 3;173(4):1031-1044.e13.

Cell Size Control via an Unstable Accumulating Activator and the Phenomenon of Excess Mitotic Delay.
Rhind N.
Bioessays. 2018 Feb;40(2).

Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication Mapping.
Klein, K., Wang, W., Borrman, T., Chan, S., Zhang, D., Weng, Z., Hastie, A., Chen, C., Gilbert, D., and Rhind, N. (2017).
bioRxiv. 2017 Nov 6:214841.

The Fission Yeast S-Phase Cyclin Cig2 Can Drive Mitosis.
Magner, M., Keifenheim, D., and Rhind, N. (2017).
bioRxiv. 2017 Nov 2:213330.

Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA.
Iyer DR, Rhind N.
PLoS Genet. 2017 Aug 14;13(8):e1006958.

Analysis of DNA Replication in Fission Yeast by Combing.
Iyer DR, Das S, Rhind N.
Cold Spring Harb Protoc. 2018 Mar 1;2018(3):pdb.prot092015.

Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System.
Santaguida S, Richardson A, Iyer DR, M'Saad O, Zasadil L, Knouse KA, Wong YL, Rhind N, Desai A, Amon A.
Dev Cell. 2017 Jun 19;41(6):638-651.e5.

Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch.
Hwang Y, Futran M, Hidalgo D, Pop R, Iyer DR, Scully R, Rhind N, Socolovsky M.
Sci Adv. 2017 May 26;3(5):e1700298.

Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast.
Keifenheim D, Sun XM, D'Souza E, Ohira MJ, Magner M, Mayhew MB, Marguerat S, Rhind N.
Curr Biol. 2017 May 22;27(10):1491-1497.e4.

An estradiol-inducible promoter enables fast, graduated control of gene expression in fission yeast.
Ohira MJ, Hendrickson DG, Scott McIsaac R, Rhind N.
Yeast. 2017 Aug;34(8):323-334.

The Intra-S Checkpoint Responses to DNA Damage.
Iyer DR, Rhind N.
Genes (Basel). 2017 Feb 17;8(2). pii: E74.

Corrigendum: Replication timing is regulated by the number of MCMs loaded at origins.
Das SP, Borrman T, Liu VW, Yang SC, Bechhoefer J, Rhind N.
Genome Res. 2016 Dec;26(12):1761.

Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind N.
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3676-85.

How and why multiple MCMs are loaded at origins of DNA replication.
Das SP, Rhind N.
Bioessays. 2016 Jul;38(7):613-7.

Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS, Beckley JR, Ren L, Feoktistova A, Jensen MA, Rhind N, Gould KL.
Yeast. 2016 Sep;33(9):507-17.

Replication timing is regulated by the number of MCMs loaded at origins.
Das SP, Borrman T, Liu VW, Yang SC, Bechhoefer J, Rhind N.
Genome Res. 2015 Dec;25(12):1886-92.

Incorporation of thymidine analogs for studying replication kinetics in fission yeast.
Rhind N.
Methods Mol Biol. 2015;1300:99-104.

Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.
Chen JS, Beckley JR, McDonald NA, Ren L, Mangione M, Jang SJ, Elmore ZC, Rachfall N, Feoktistova A, Jones CM, Willet AH, Guillen R, Bitton DA, Bähler J, Jensen MA, Rhind N, Gould KL.
G3 (Bethesda). 2014 Dec 31;5(3):361-70.

The three most important things about origins: location, location, location.
Rhind N.
Mol Syst Biol. 2014 Apr 4;10:723.

Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.
Chen W, Shulha HP, Ashar-Patel A, Yan J, Green KM, Query CC, Rhind N, Weng Z, Moore MJ.
RNA. 2014 Mar;20(3):308-20.

Checkpoint regulation of replication forks: global or local?
Iyer DR, Rhind N.
Biochem Soc Trans. 2013 Dec;41(6):1701-5.

The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.
Ivanova T, Alves-Rodrigues I, Gómez-Escoda B, Dutta C, DeCaprio JA, Rhind N, Hidalgo E, Ayté J.
Mol Biol Cell. 2013 Nov;24(21):3350-7.

Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase.
Yu ZY, Zhang MT, Wang GY, Xu D, Keifenheim D, Franco A, Cansado J, Masuda H, Rhind N, Wang Y, Jin QW.
J Cell Sci. 2013 Nov 1;126(Pt 21):4995-5004.

DNA replication timing.
Rhind N, Gilbert DM.
Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a010132

Signaling pathways that regulate cell division.
Rhind N, Russell P.
Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a005942.

Genome-wide identification and characterization of replication origins by deep sequencing.
Xu J, Yanagisawa Y, Tsankov AM, Hart C, Aoki K, Kommajosyula N, Steinmann KE, Bochicchio J, Russ C, Regev A, Rando OJ, Nusbaum C, Niki H, Milos P, Weng Z, Rhind N.
Genome Biol. 2012 Apr 24;13(4):R27.

Replication timing and its emergence from stochastic processes.
Bechhoefer J, Rhind N.
Trends Genet. 2012 Aug;28(8):374-81.

Evolutionary divergence of intrinsic and trans-regulated nucleosome positioning sequences reveals plastic rules for chromatin organization.
Tsankov A, Yanagisawa Y, Rhind N, Regev A, Rando OJ.
Genome Res. 2011 Nov;21(11):1851-62.

Studying S-phase DNA damage checkpoints using the fission yeast Schizosaccharomyces pombe.
Willis N, Rhind N.
Methods Mol Biol. 2011;782:13-21.

Studying G2 DNA damage checkpoints using the fission yeast Schizosaccharomyces pombe.
Willis N, Rhind N.
Methods Mol Biol. 2011;782:1-12.

Full-length transcriptome assembly from RNA-Seq data without a reference genome.
Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I, Adiconis X, Fan L, Raychowdhury R, Zeng Q, Chen Z, Mauceli E, Hacohen N, Gnirke A, Rhind N, di Palma F, Birren BW, Nusbaum C, Lindblad-Toh K, Friedman N, Regev A.
Nat Biotechnol. 2011 May 15;29(7):644-52.

Comparative functional genomics of the fission yeasts.
Rhind N, Chen Z, Yassour M, Thompson DA, Haas BJ, Habib N, Wapinski I, Roy S, Lin MF, Heiman DI, Young SK, Furuya K, Guo Y, Pidoux A, Chen HM, Robbertse B, Goldberg JM, Aoki K, Bayne EH, Berlin AM, Desjardins CA, Dobbs E, Dukaj L, Fan L, FitzGerald MG, French C, Gujja S, Hansen K, Keifenheim D, Levin JZ, Mosher RA, Müller CA, Pfiffner J, Priest M, Russ C, Smialowska A, Swoboda P, Sykes SM, Vaughn M, Vengrova S, Yoder R, Zeng Q, Allshire R, Baulcombe D, Birren BW, Brown W, Ekwall K, Kellis M, Leatherwood J, Levin H, Margalit H, Martienssen R, Nieduszynski CA, Spatafora JW, Friedman N, Dalgaard JZ, Baumann P, Niki H, Regev A, Nusbaum C.
Science. 2011 May 20;332(6032):930-6.

Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.
Limbo O, Porter-Goff ME, Rhind N, Russell P.
Mol Cell Biol. 2011 Feb;31(3):573-83.

Modeling genome-wide replication kinetics reveals a mechanism for regulation of replication timing.
Yang SC, Rhind N, Bechhoefer J.
Mol Syst Biol. 2010 Aug 24;6:404.

Reconciling stochastic origin firing with defined replication timing.
Rhind N, Yang SC, Bechhoefer J.
Chromosome Res. 2010 Jan;18(1):35-43.

The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.
Willis N, Rhind N.
Genetics. 2010 Apr;184(4):887-97.

The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.
Dutta C, Rhind N.
PLoS One. 2009 Sep 11;4(9):e6944.

Regulation of DNA replication by the S-phase DNA damage checkpoint.
Willis N, Rhind N.
Cell Div. 2009 Jul 3;4:13.

Incorporation of thymidine analogs for studying replication kinetics in fission yeast.
Rhind N.
Methods Mol Biol. 2009;521:509-15.

Changing of the guard: how ATM hands off DNA double-strand break signaling to ATR.
Rhind N.
Mol Cell. 2009 Mar 27;33(6):672-4.

The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling.
Porter-Goff ME, Rhind N.
Mol Biol Cell. 2009 Apr;20(7):2096-107.

Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.
Willis N, Rhind N.
Mol Biol Cell. 2009 Feb;20(3):819-33.

The Hsk1(Cdc7) replication kinase regulates origin efficiency.
Patel PK, Kommajosyula N, Rosebrock A, Bensimon A, Leatherwood J, Bechhoefer J, Rhind N.
Mol Biol Cell. 2008 Dec;19(12):5550-8.

An intrinsic checkpoint model for regulation of replication origins.
Rhind N.
Cell Cycle. 2008 Sep 1;7(17):2619-20.

The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription.
Dutta C, Patel PK, Rosebrock A, Oliva A, Leatherwood J, Rhind N.
Mol Cell Biol. 2008 Oct;28(19):5977-85.

Just-in-time DNA replication.
Jun S, Rhind N.
Physics (College Park Md). 2008;1. pii: 32.

DNA replication timing: random thoughts about origin firing.
Rhind N.
Nat Cell Biol. 2006 Dec;8(12):1313-6.

Cdc2 tyrosine phosphorylation is not required for the S-phase DNA damage checkpoint in fission yeast.
Kommajosyula N, Rhind N.
Cell Cycle. 2006 Nov 1;5(21):2495-500.

Basic methods for fission yeast.
Forsburg SL, Rhind N.
Yeast. 2006 Feb;23(3):173-83. Review.

DNA replication origins fire stochastically in fission yeast.
Patel PK, Arcangioli B, Baker SP, Bensimon A, Rhind N.
Mol Biol Cell. 2006 Jan;17(1):308-16.

A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe.
Sigova A, Rhind N, Zamore PD.
Genes Dev. 2004 Oct 1;18(19):2359-67.

In vivo labeling of fission yeast DNA with thymidine and thymidine analogs.
Sivakumar S, Porter-Goff M, Patel PK, Benoit K, Rhind N.
Methods. 2004 Jul;33(3):213-9.

The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint.
Chahwan C, Nakamura TM, Sivakumar S, Russell P, Rhind N.
Mol Cell Biol. 2003 Sep;23(18):6564-73.

DNA damage checkpoint control of mitosis in fission yeast.
Rhind N, Baber-Furnari BA, Lopez-Girona A, Boddy MN, Brondello JM, Moser B, Shanahan P, Blasina A, McGowan C, Russell P.
Cold Spring Harb Symp Quant Biol. 2000;65:353-9. Review.

Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints.
Rhind N, Russell P.
Mol Cell Biol. 2001 Mar;21(5):1499-508.

Checkpoints: it takes more than time to heal some wounds.
Rhind N, Russell P.
Curr Biol. 2000 Dec 14-28;10(24):R908-11. Review.

Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.
Rhind N, Russell P.
J Cell Sci. 2000 Nov;113 ( Pt 22):3889-96. Review.

Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint.
Baber-Furnari BA, Rhind N, Boddy MN, Shanahan P, Lopez-Girona A, Russell P.
Mol Biol Cell. 2000 Jan;11(1):1-11.

Child sexual abuse in Hong Kong: double victimization?
Rhind N, Leung T, Choi F.
Child Abuse Negl. 1999 May;23(5):511-7.

Mitotic DNA damage and replication checkpoints in yeast.
Rhind N, Russell P.
Curr Opin Cell Biol. 1998 Dec;10(6):749-58. Review.

The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage.
Rhind N, Russell P.
Genetics. 1998 Aug;149(4):1729-37.

Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe.
Rhind N, Russell P.
Mol Cell Biol. 1998 Jul;18(7):3782-7.

Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.
Furnari B, Rhind N, Russell P.
Science. 1997 Sep 5;277(5331):1495-7.

Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.
Rhind N, Furnari B, Russell P.
Genes Dev. 1997 Feb 15;11(4):504-11.

xol-1 acts as an early switch in the C. elegans male/hermaphrodite decision.
Rhind NR, Miller LM, Kopczynski JB, Meyer BJ.
Cell. 1995 Jan 13;80(1):71-82.

A tumorigenic murine Sertoli cell line that is temperature-sensitive for differentiation.
Boekelheide K, Lee JW, Hall SJ, Rhind NR, Zaret KS.
Am J Pathol. 1993 Oct;143(4):1159-68.

Royal patronage and the hospital service.
Rhind N.
Nurs Mirror. 1977 Jun 2;144(22):13-6.