The mission of the Skin Diseases Research Core is to establish an efficient way to conduct preclinical mouse studies and translational research services to investigate skin diseases for UMMS faculty as well as investigators from external sources. Preclinical studies will include testing novel treatments in mouse models of skin disease for efficacy and mechanism of action, as well as exploring functional contributions of cells or proteins in the pathogenesis of skin diseases. Existing mouse models include vitiligo (developed by Dr. John Harris), psoriasis (imiquimod-induced), and lupus (developed by Dr. Ann Rothstein in the Dept of Medicine). Translational studies will include recruiting subjects with skin diseases and sampling their skin and blood for analysis of cells and proteins. To date we have recruited vitiligo, psoriasis, and lupus patients for translational studies, and have shared samples with collaborators at UMMS as well as externally.