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James Frencher, MD

Internship: Icahn School of Medicine at Mount Sinai - New York, NY – Preliminary Surgery Year

Medical School: University of Illinois College of Medicine at Chicago – Chicago, IL

Undergraduate College: University of Michigan – Ann Arbor

Hometown: Detroit, Michigan

Clinical Interests: Interventional Oncology, Theranostics, Immunotherapy, Locoregional Pain Interventions

Personal Interests: Weightlifting, Baking, Hiking

Publications:

Shen L, Huang D, Qaqish A, Frencher J, Yang R, Shen H, Chen ZW. Fast-acting γδ T-cell subpopulation and protective immunity against infections. Immunol Reviews. 2020 Nov.

L. Shen, J Frencher, D Huang, W. Wang, E Yang, CY Vhen, Z Zhang, R Wang, A Qaqish, MH Larsen, H Shen, SA Porcelli, WR Jacobs Jr, ZW Chen. “Immunization of Vg2Vd2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates.” PNAS. Mar 26 2019.

A. Qaqish, D Huang, C Chen, Z. Zhang, R Wang, S Li, E Yang, Y Lu, M Larsen. W Jacobs, L Qian, J Frencher, L Shen, Z Chen. “Adoptive Transfer of Phosphoantigen-specific gamma/delta T cell subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates”. Journal of Immunology. June 15 2017.

H. Shen, Y. Wang, C. Chen, J. Frencher, D. Huang, B, Ryan-Payseur, Z. Chen. “Th17-related cytokines induce in vitro recall-like expansion and effector function of HMBPP-specific Vγ2Vδ2 T cells after infections” European Journal of Immunology. July 2015.

J. Frencher, H. Shen, L. Yan, A. Rizzo, N. Freitag, L. Shen, Z. Chen. Infection with HMBPP-deficient IPP-producing Listeria mutant alters pulmonary and systemic immune responses, effector functions, and memory polarization of Vγ2Vδ2 T cells. Journal of Leukocyte Biology. July 2014.

J. Frencher, B. Ryan-Payseur, D. Huang, R. Wang, P. McMullen, N. Letvin, W. Collins, N. Freitag, M. Malkovsky, C. Chen, L. Shen, Z. Chen “SHIV Antigen Immunization Alters Patterns of Immune Responses to SHIV/malaria Co-infection and Protects against Life-threatening SHIV-related Malaria.” J Infect Dis. 2013 Apr 8.

B. Ryan-Payseur, J. Frencher, L. Shen, C. Chen, D. Huang, Z. Chen. “Multieffector-functional immune responses of HMBPP-specific Vγ2Vδ2 T cells in nonhuman primates inoculated with Listeria monocytogenes ΔactA prfA*.” J. Immunol 2012 Aug 1;189(3):1285-93.

J. Qiu, L. Yan, J. Chen, C. Chen, L. Shen, N. Letvin, B. Haynes, N. Freitag, L. Rong, J. Frencher, D. Huang, X. Wang, Z.Chen “Intranasal vaccination with the recombinant Listeria monocytogenes ΔactA prfA* mutant elicits robust systemic and pulmonary cellular responses and secretory mucosal IgA.” Clin Vaccine Immunol. 2011 Apr;18(4):640-6.

Awards:

UIC Urban Health Program Jose Celso Barbosa Scholarship Award
UIC Medical Scientist Training Program Travel Award
International Gamma Delta T Cell Conference Travel Award
University of Illinois College of Medicine Research Day Gold Prize Winner
University of Michigan Cancer Center Research Fellowship

Presentations (selected):

12^th Annual Meeting of Chinese Society for Immunology – Tianjin, China - Listeria monocytogenes as an adjuvant stimulus for Pattern-specific T cells and host responses to Mycobacterium tuberculosis – October 26, 2017.
International Gamma Delta T Cell Conference, Freiburg Germany - “Knock out of HMBPP Synthase in recombinant Listeria vaccine vector reduced the ability of the vaccine to induce Vγ2Vδ2 T-cell expansion and elicit Th17 and Th22 αβ T cell responses in macaques” June 1, 2012