The Nucleic Acid Chemistry Center (NACC), part of the RNA Therapeutics Institute (RTI) at UMass Chan Medical School, was founded in 2014 by Anastasia Khvorova, PhD. The center’s growth has been supported by NIH Shared Instrumentation and High-End Instrumentation awards in 2015 and 2024, enabling the establishment of a Mid-Scale RNA Synthesis, Purification, and Quality Control System and a new High-Throughput Oligonucleotide Production System. Currently, the NACC is the only nonprofit center in North America with the infrastructure and expertise to synthesize complex RNA from nanomole to multi-gram scale.
The NACC provides access to cutting-edge RNA chemistry and therapeutic RNA production to dozens of labs within and outside UMass Chan. To date, the center has synthesized more than 50,000 complex, fully modified oligonucleotides supporting a wide range of therapeutic technologies, including siRNAs, ASOs, gapmers, CRISPR, and sgRNAs.
Current collaborators: Please remember to cite both NACC NIH grants in your publications.
This work was supported by NIH grant S10OD020012 for the Mid-Scale RNA Synthesis, Purification, and Quality Control System.
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This work was supported by NIH grant S10OD036329 for the High-throughput Oligonucleotide Production System.
