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Recent Metabolism Publications from MetNet Faculty

Wang G, Yu Y, Cai W, Batista TM, Suk S, Noh HL, Hirshman M, Nigro P, Li ME, Softic S, Goodyear L, Kim JK, Kahn CR. Muscle Specific Insulin Receptor Overexpression Protects Mice from Diet-Induced Glucose Intolerance but Leads to Post-Receptor Insulin Resistance. Diabetes. 2020 Aug 31. doi: 10.2337/db20-0439.

Na H, Zdraljevic S, Tanny RE, Walhout AJM, Andersen EC. Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model. PLoS Genet. 2020 Aug 28;16(8):e1008984. doi: 10.1371/journal.pgen.1008984.

Henriques F, Bedard AH, Guilherme A, Kelly M, Chi J, Zhang P, Lifshitz LM, Bellvé K, Rowland LA, Yenilmez B, Kumar S, Wang Y, Luban J, Weinstein LS, Lin JD, Cohen P, Czech MP. Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis. Cell Rep. 2020 Aug 04; 32(5):107998. doi: 10.1016/j.celrep.2020.107998.

Roderick JE, Gallagher KM, Murphy LC, O'Connor KW, Tang K, Zhang B, Brehm M, Greiner DL, Yu J, Zhu LJ, Green MR, Kelliher MA. Prostaglandin E2 stimulates cAMP signaling and re-sensitizes human leukemia cells to glucocorticoid-induced cell death. Blood. 2020 Aug 05. PMID: 32756933. doi: 10.1182/blood.2020005712.

Endogenous toxic metabolites and implications in cancer therapy. Lee N, Spears ME, Carlisle AE, Kim D. Oncogene. 2020 Aug;39(35):5709-5720. doi: 10.1038/s41388-020-01395-9. Epub 2020 Jul 24.

Thielen LA, Chen J, Jing G, Moukha-Chafiq O, Xu G, Jo S, Grayson TB, Lu B, Li P, Augelli-Szafran CE, Suto MJ, Kanke M, Sethupathy P, Kim JK, Shalev A. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Jul 22. doi: 10.1016/j.cmet.2020.07.002. Epub 2020 Jul 28.

Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling. Entwisle SW, Martinez Calejman C, Valente AS, Lawrence RT, Hung CM, Guertin DA, Villén J. Mol Cell Proteomics. 2020 Jul;19(7):1104-1119. doi: 10.1074/mcp.RA120.001946. Epub 2020 Mar 31.

Gallagher KM, Roderick JE, Tan SH, Tan TK, Murphy L, Yu J, Li R, O'Connor KW, Zhu J, Green MR, Sanda T, Kelliher MA. ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia. Blood Adv. 2020 Jul 14; 4(13):3154-3168. doi: 10.1182/bloodadvances.2020001555.

Selenium detoxification is required for cancer-cell survival. Carlisle AE, Lee N, Matthew-Onabanjo AN, Spears ME, Park SJ, Youkana D, Doshi MB, Peppers A, Li R, Joseph AB, Smith M, Simin K, Zhu LJ, Greer PL, Shaw LM, Kim D. Nat Metab. 2020 Jul;2(7):603-611. doi: 10.1038/s42255-020-0224-7. Epub 2020 Jul 6.

Padilla-Benavides T, Reyes-Gutierrez P, Imbalzano AN. Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis. Biology (Basel). 2020 Jul 03; 9(7). PMID: 32635263. doi: 10.3390/biology9070152.

Cubero FJ, Mohamed MR, Woitok MM, Zhao G, Hatting M, Nevzorova YA, Chen C, Haybaeck J, de Bruin A, Avila MA, Boekschoten MV, Davis RJ, Trautwein C. Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatol Commun. 2020 Jun; 4(6):834-851. doi: 10.1002/hep4.1495. eCollection 2020 Jun.

Anderson NS, Haynes CM. Folding the Mitochondrial UPR into the Integrated Stress Response. Trends Cell Biol. 2020 Jun; 30(6):428-439. PMID: 32413314. doi: 10.1016/j.tcb.2020.03.001. Epub 2020 Apr 2.

Goodman RP, Markhard AL, Shah H, Sharma R, Skinner OS, Clish CB, Deik A, Patgiri A, Hsu YH, Masia R, Noh HL, Suk S, Goldberger O, Hirschhorn JN, Yellen G, Kim JK, Mootha VK. Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature. 2020. Epub 2020/05/29. doi: 10.1038/s41586-020-2337-2.

Tran KV, Brown EL, DeSouza T, Jespersen NZ, Nandrup-Bus C, Yang Q, Yang Z, Desai A, Min SY, Rojas-Rodriguez R, Lundh M, Feizi A, Willenbrock H, Larsen TJ, Severinsen MCK, Malka K, Mozzicato AM, Deshmukh AS, Emanuelli B, Pedersen BK, Fitzgibbons T, Scheele C, Corvera S, Nielsen S. Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473. Nat Metab. 2020;2(5):397-412. Epub 2020/05/23. doi: 10.1038/s42255-020-0205-x.

Cheng SY, Cipi J, Ma S, Hafler BP, Kanadia RN, Brush RS, Agbaga MP, Punzo C. Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies. Proc Natl Acad Sci U S A. 2020 May 20. doi: 10.1073/pnas.2000339117. Epub 2020 May 20.

Castilla LH. NRAS palmitoylation and oncogenic fitness. Blood. 2020 May 14; 135(20):1725-1726. PMID: 32407527. doi: 10.1182/blood.2020005720.

Choudhury A, Bullock D, Lim A, Argemi J, Orning P, Lien E, Bataller R, Mandrekar P. Inhibition of HSP90 and activation of HSF1 diminishes macrophage NLRP3 inflammasome activity in alcoholic liver injury. Alcohol Clin Exp Res. 2020 Apr 13. doi: 10.1111/acer.14338. Epub 2020 May 18.

Czech MP. Mechanisms of insulin resistance related to white, beige, and brown adipocytes. Mol Metab. 2020;34:27-42. Epub 2020/03/18. doi: 10.1016/j.molmet.2019.12.014.

Walker RG, Barrandon O, Poggioli T, Dagdeviren S, Carroll SH, Mills MJ, Mendello KR, Gomez Y, Loffredo FS, Pancoast JR, Macias-Trevino C, Marts C, LeClair KB, Noh HL, Kim T, Banks AS, Kim JK, Cohen DE, Wagers AJ, Melton DA, Lee RT. Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice. Sci Rep. 2020;10(1):4561. Epub 2020/03/14. doi: 10.1038/s41598-020-61443-y.

Brown CW, Mercurio AM. Ferroptosis resistance mediated by exosomal release of iron. Mol Cell Oncol. 2020; 7(3):1730144. doi: 10.1080/23723556.2020.1730144. eCollection 2020.

Batista TM, Dagdeviren S, Carroll SH, Cai W, Melnik VY, Noh HL, Saengnipanthkul S, Kim JK, Kahn CR, Lee RT. Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver. Proc Natl Acad Sci U S A. 2020;117(12):6733-40. Epub 2020/03/12. doi: 10.1073/pnas.1922370117.

Romanelli-Credrez L, Doitsidou M, Alkema MJ, Salinas G. HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium. Front Genet. 2020; 11:63. doi: 10.3389/fgene.2020.00063. eCollection 2020.

Mandrekar P. Targeting Epigenetic Mechanisms to Alleviate Alcoholic Steatosis. Cell Mol Gastroenterol Hepatol. 2020 Feb 22. doi: 10.1016/j.jcmgh.2020.01.013. Epub 2020 Feb 22.

Naito MG, Xu D, Amin P, Lee J, Wang H, Li W, Kelliher M, Pasparakis M, Yuan J. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proc Natl Acad Sci U S A. 2020 Feb 18. doi: 10.1073/pnas.1916427117. Epub 2020 Feb 18.

Frisoli ML, Essien K, Harris JE. Vitiligo: Mechanisms of Pathogenesis and Treatment. Annu Rev Immunol. 2020 Feb 04. PMID: 32017656. doi: 10.1146/annurev-immunol-100919-023531. Epub 2020 Feb 4.

Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2751-2760. doi: 10.1073/pnas.1920004117. Epub 2020 Jan 24.

Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Villen J, Wellen KE, Guertin DA. mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis. Nat Commun. 2020;11(1):575. Epub 2020/01/31. doi: 10.1038/s41467-020-14430-w.

Allen EA, Baehrecke EH. Autophagy in animal development. Cell Death Differ. 2020 Jan 27. PMID: 31988494. doi: 10.1038/s41418-020-0497-0. Epub 2020 Jan 27.