Structural Basis and Distal Effects of Gag Substrate Coevolution in Drug Resistance to HIV-1 Protease
While evolving high levels of resistance to protease inhibitors, HIV-1 accumulates mutations not only in the protease but also its substrates. In this work we revealed the molecular-level interplay between these two types of resistance mutations, and how co-evolution of the substrate restores the structure and dynamics of the complex to allow evolution of resistant viral variants.