Lab News

Our latest bioRxiv preprints

Dcp2 C-terminal Cis-Binding Elements Control Selective Targeting of the Decapping Enzyme by Forming Distinct Decapping Complexes
Feng He, Chan Wu, Allan Jacobson
https://www.biorxiv.org/content/10.1101/2021.10.01.462794v1

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae
Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard Baker, Allan Jacobson
bioRxiv 2020.12.15.422930; doi 

Our latest papers

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae 
Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard Baker, and Allan Jacobson
PLoS Genetics 17: e1009538, 2021; doi 

Dual mechanism of action of PTC299 and other DHODH inhibitors in suppressing SARS-CoV-2 replication and cellular cytokine storms 
Elizabeth Goodwin, Allan Jacobson, Marla Weetall, Jason D. Graci, Ellen M. Welch, Kylie O’Keefe, Stuart W. Peltz
J. Cytokine Biol. 6: 10037, 2021; doi 

Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination
Chan Wu, Bijoyita Roy, Feng He, Kevin Yan, and Allan Jacobson
Cell Reports 33:108399, 2020; doi 

The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines
Jeremy Luban, Rachel A. Sattler, Elke Mühlberger et al.
Virus Research 292: 198246, 2021; doi