Publications
The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.
Sharma T, Robinson DCL, Witwicka H, Dilworth FJ, Imbalzano AN.
Nucleic Acids Res. 2021 Aug 20;49(14):8060-8077.
Protein arginine methyltransferase PRMT5 regulates fatty acid metabolism and lipid droplet biogenesis in white adipose tissues.
Jia, Z, F Yue, X Chen, N Narayanan, J Qiu, SA Syed, AN Imbalzano, M Deng, P Yu, C Hu, and S Kuang.
Adv. Sci. 2020. 7:2002602.
Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis.
Padilla-Benavides T, Reyes-Gutierrez P, Imbalzano AN.
Biology (Basel). 2020 Jul 3;9(7):E152.
CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis.
Padilla-Benavides T, Haokip DT, Yoon Y, Reyes-Gutierrez P, Rivera-Pérez JA, Imbalzano AN.
Int J Mol Sci. 2020 Jan 30;21(3).
The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper.
Tavera-Montañez C, Hainer SJ, Cangussu D, Gordon SJV, Xiao Y, Reyes-Gutierrez P, Imbalzano AN, Navea JG, Fazzio TG, Padilla-Benavides T.
FASEB J. 2019 Nov 5:fj201901606R. doi: 10.1096/fj.201901606R. [Epub ahead of print]
BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer.
Muthuswami R, Bailey L, Rakesh R, Imbalzano AN*, Nickerson JA, Hockensmith JW.
J Cell Physiol. 2019 Sep. 234:15194-15205. (* corresponding author)
Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function.
Reyes-Gutierrez P, Carrasquillo-Rodríguez JW, Imbalzano AN.
PLoS One. 2019 Aug 20;14(8):e0216015. doi: 10.1371/journal.pone.0216015. eCollection 2019.
Calcineurin broadly regulates the initiation of skeletal muscle-specific gene expression by binding target promoters and facilitating the interaction of the SWI/SNF chromatin remodeling enzyme.
Witwicka, H, J Nogami, SA Syed, K Maehara, T Padilla-Benavides, Y Ohkawa and AN Imbalzano.
Mol. Cell. Biol. 2019 Jul 15. pii: MCB.00063-19. In press.
Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.
Fritz AJ, Gillis NE, Gerrard DL, Rodriguez PD, Hong D, Rose JT, Ghule PN, Bolf EL, Gordon JA, Tye CE, Boyd JR, Tracy KM, Nickerson JA, van Wijnen AJ, Imbalzano AN, Heath JL, Frietze SE, Zaidi SK, Carr FE, Lian JB, Stein JL, Stein GS.
Genes Chromosomes Cancer. 2019 Jul;58(7):484-499. Review.
RUNX1-dependent mechanisms in biological control and dysregulation in cancer.
Hong D, Fritz AJ, Gordon JA, Tye CE, Boyd JR, Tracy KM, Frietze SE, Carr FE, Nickerson JA, Van Wijnen AJ, Imbalzano AN, Zaidi SK, Lian JB, Stein JL, Stein GS.
J Cell Physiol. 2019 Jun;234(6):8597-8609. Review.
Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity.
Hong D, Fritz AJ, Zaidi SK, van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS.
J Cell Physiol. 2018 Dec;233(12):9136-9144. Review.
Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes.
Zaidi SK, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS.
Mol Cancer Res. 2018 Nov;16(11):1617-1624.
Nuclear organization mediates cancer-compromised genetic and epigenetic control.
Zaidi SK, Fritz AJ, Tracy KM, Gordon JA, Tye CE, Boyd J, Van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS.
Adv Biol Regul. 2018 Aug; 69:1-10. Review.
Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.
Fritz AJ, Ghule PN, Boyd JR, Tye CE, Page NA, Hong D, Shirley DJ, Weinheimer AS, Barutcu AR, Gerrard DL, Frietze S, van Wijnen AJ, Zaidi SK, Imbalzano AN, Lian JB, Stein JL, Stein GS.
J Cell Physiol. 2018 Feb;233(2):1278-1290.
Temporal regulation of chromatin during myoblast differentiation.
Harada A, Ohkawa Y, Imbalzano AN.
Semin Cell Dev Biol. 2017 Dec;72:77-86.
Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer.
Zaidi SK, Frietze SE, Gordon JA, Heath JL, Messier T, Hong D, Boyd JR, Kang M, Imbalzano AN, Lian JB, Stein JL, Stein GS.
Mol Cell Biol. 2017 Nov 13;37(23). pii: e00352-17.
Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition.
Padilla-Benavides T, Nasipak BT, Paskavitz AL, Haokip DT, Schnabl JM, Nickerson JA, Imbalzano AN.
J Biol Chem. 2017 Nov 10;292(45):18592-18607.
The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer.
Wu Q, Lian JB, Stein JL, Stein GS, Nickerson JA, Imbalzano AN.
Epigenomics. 2017 Jun;9(6):919-931.
Identifying Nuclear Matrix-Attached DNA Across the Genome.
Dobson JR, Hong D, Barutcu AR, Wu H, Imbalzano AN, Lian JB, Stein JL, van Wijnen AJ, Nickerson JA, Stein GS.
J Cell Physiol. 2017 Jun;232(6):1295-1305.
Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming.
Nickerson JA, Wu Q, Imbalzano AN.
Front Oncol. 2017 Apr 4;7:49.
The connection between BRG1, CTCF and topoisomerases at TAD boundaries.
Barutcu AR, Lian JB, Stein JL, Stein GS, Imbalzano AN.
Nucleus. 2017 Mar 4;8(2):150-155.
RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.
Barutcu AR, Hong D, Lajoie BR, McCord RP, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS.
Biochim Biophys Acta. 2016 Nov;1859(11):1389-1397.
SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.
Barutcu AR, Lajoie BR, Fritz AJ, McCord RP, Nickerson JA, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Stein GS, Imbalzano AN.
Genome Res. 2016 Sep;26(9):1188-201.
The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation.
Wu Q, Madany P, Dobson JR, Schnabl JM, Sharma S, Smith TC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Muthuswami R, Imbalzano AN, Nickerson JA.
Oncotarget. 2016 Jun 21;7(25):38270-38281.
Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase.
LeBlanc SE, Wu Q, Lamba P, Sif S, Imbalzano AN.
Nucleic Acids Res. 2016 Jun 20;44(11):5133-47.
Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.
Gerstenberger BS, Trzupek JD, Tallant C, Fedorov O, Filippakopoulos P, Brennan PE, Fedele V, Martin S, Picaud S, Rogers C, Parikh M, Taylor A, Samas B, O'Mahony A, Berg E, Pallares G, Torrey AD, Treiber DK, Samardjiev IJ, Nasipak BT, Padilla-Benavides T, Wu Q, Imbalzano AN, Nickerson JA, Bunnage ME, Müller S, Knapp S, Owen DR.
J Med Chem. 2016 May 26;59(10):4800-11.
Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells.
Wu Q, Sharma S, Cui H, LeBlanc SE, Zhang H, Muthuswami R, Nickerson JA, Imbalzano AN.
Oncotarget. 2016 May 10;7(19):27158-75.
Global gene expression profiling of JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts.
Hu YJ, Imbalzano AN.
Sci Data. 2016 Apr 12;3:160022.
Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus.
Fritz AJ, Barutcu AR, Martin-Buley L, van Wijnen AJ, Zaidi SK, Imbalzano AN, Lian JB, Stein JL, Stein GS.
J Cell Biochem. 2016 Jan;117(1):9-19.
C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization.
Barutcu AR, Fritz AJ, Zaidi SK, van Wijnen AJ, Lian JB, Stein JL, Nickerson JA, Imbalzano AN, Stein GS.
J Cell Physiol. 2016 Jan;231(1):31-5.
Brg1 Controls the Expression of Pax7 to Promote Viability and Proliferation of Mouse Primary Myoblasts.
Padilla-Benavides T, Nasipak BT, Imbalzano AN.
J Cell Physiol. 2015 Dec;230(12):2990-7.
The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.
Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, Browne G, Colby JL, Winter GE, Bradner JE, Pratap J, Sluder G, Bhargava R, Chiosea SI, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Nickerson JA, Imbalzano AN.
J Cell Physiol. 2015 Nov;230(11):2683-94.
Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells.
Barutcu AR, Lajoie BR, McCord RP, Tye CE, Hong D, Messier TL, Browne G, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS.
Genome Biol. 2015 Sep 28;16:214.
Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN.
Nucleic Acids Res. 2015 Sep 18;43(16):7790-804.
Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.
Nasipak BT, Padilla-Benavides T, Green KM, Leszyk JD, Mao W, Konda S, Sif S, Shaffer SA, Ohkawa Y, Imbalzano AN.
Nat Commun. 2015 Jun 17;6:7441.
Spatial re-organization of myogenic regulatory sequences temporally controls gene expression.
Harada A, Mallappa C, Okada S, Butler JT, Baker SP, Lawrence JB, Ohkawa Y, Imbalzano AN.
Nucleic Acids Res. 2015 Feb 27;43(4):2008-21.
Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response.
Yang S, Quaresma AJ, Nickerson JA, Green KM, Shaffer SA, Imbalzano AN, Martin-Buley LA, Lian JB, Stein JL, van Wijnen AJ, Stein GS.
J Cell Sci. 2015 Feb 15;128(4):728-40.
Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development.
Cho OH, Mallappa C, Hernández-Hernández JM, Rivera-Pérez JA, Imbalzano AN.
Dev Dyn. 2015 Jan;244(1):43-55.
The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter.
Barutcu AR, Tai PW, Wu H, Gordon JA, Whitfield TW, Dobson JR, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS.
Nucleic Acids Res. 2014;42(16):10360-72.
Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.
Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM.
Oncogene. 2014 May 8;33(19):2441-53.
The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner.
LeBlanc SE, Wu Q, Barutcu AR, Xiao H, Ohkawa Y, Imbalzano AN.
PLoS One. 2014 Jan 20;9(1):e86140.
Prmt7 is dispensable in tissue culture models for adipogenic differentiation.
Hu YJ, Sif S, Imbalzano AN.
F1000Res. 2013 Dec 18;2:279.
BRG1, a SWI/SNF chromatin remodeling enzyme ATPase, is required for maintenance of nuclear shape and integrity.
Imbalzano AN, Imbalzano KM, Nickerson JA.
Commun Integr Biol. 2013 Sep 1;6(5):e25153.
The Scaffold attachment factor b1 (Safb1) regulates myogenic differentiation by facilitating the transition of myogenic gene chromatin from a repressed to an activated state.
Hernández-Hernández JM, Mallappa C, Nasipak BT, Oesterreich S, Imbalzano AN.
Nucleic Acids Res. 2013 Jun;41(11):5704-16.
Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections.
Imbalzano KM, Cohet N, Wu Q, Underwood JM, Imbalzano AN, Nickerson JA.
PLoS One. 2013;8(2):e55628.
Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice.
Tortelote GG, Hernández-Hernández JM, Quaresma AJ, Nickerson JA, Imbalzano AN, Rivera-Pérez JA.
Dev Biol. 2013 Feb 1;374(1):164-73.
Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1.
Karkhanis V, Wang L, Tae S, Hu YJ, Imbalzano AN, Sif S.
J Biol Chem. 2012 Aug 24;287(35):29801-14.
Chd2 interacts with H3.3 to determine myogenic cell fate.
Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, Kumamaru H, Saiwai H, Tsubota T, Kurumizaka H, Akashi K, Tachibana T, Imbalzano AN, Ohkawa Y.
EMBO J. 2012 Jun 29;31(13):2994-3007.
Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor γ2 (PPARγ2) and its target genes during adipogenesis.
LeBlanc SE, Konda S, Wu Q, Hu YJ, Oslowski CM, Sif S, Imbalzano AN.
Mol Endocrinol. 2012 Apr;26(4):583-97.
An improved restriction enzyme accessibility assay for analyzing changes in chromatin structure in samples of limited cell number.
Ohkawa Y, Mallappa C, Vallaster CS, Imbalzano AN.
Methods Mol Biol. 2012;798:531-42.
Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays.
Ohkawa Y, Mallappa C, Vallaster CS, Imbalzano AN.
Methods Mol Biol. 2012;798:517-30.
Versatility of PRMT5-induced methylation in growth control and development.
Karkhanis V, Hu YJ, Baiocchi RA, Imbalzano AN, Sif S.
Trends Biochem Sci. 2011 Dec;36(12):633-41.
Chromatin immunoprecipitation assay for tissue-specific genes using early-stage mouse embryos.
Cho OH, Rivera-Pérez JA, Imbalzano AN.
J Vis Exp. 2011 Apr 29;(50). pii: 2677.
Dicer is required for the formation of white but not brown adipose tissue.
Mudhasani R, Puri V, Hoover K, Czech MP, Imbalzano AN, Jones SN.
J Cell Physiol. 2011 May;226(5):1399-406.
Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression.
Pockwinse SM, Kota KP, Quaresma AJ, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Nickerson JA.
J Cell Physiol. 2011 May;226(5):1383-9.
The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4.
Mallappa C, Hu YJ, Shamulailatpam P, Tae S, Sif S, Imbalzano AN.
Nucleic Acids Res. 2011 Mar;39(4):1243-55.
Chromatin accessibility and transcription factor binding at the PPARγ2 promoter during adipogenesis is protein kinase A-dependent.
Xiao H, Leblanc SE, Wu Q, Konda S, Salma N, Marfella CG, Ohkawa Y, Imbalzano AN.
J Cell Physiol. 2011 Jan;226(1):86-93.
Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments.
Stein GS, van Wijnen AJ, Imbalzano AN, Montecino M, Zaidi SK, Lian JB, Nickerson JA, Stein JL.
Crit Rev Eukaryot Gene Expr. 2010;20(2):149-55. Review.
The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes.
Bakshi R, Hassan MQ, Pratap J, Lian JB, Montecino MA, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS.
J Cell Physiol. 2010 Nov;225(2):569-76.
An essential role for Dicer in adipocyte differentiation.
Mudhasani R, Imbalzano AN, Jones SN.
J Cell Biochem. 2010 Jul 1;110(4):812-6.
Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function.
Mallappa C, Nasipak BT, Etheridge L, Androphy EJ, Jones SN, Sagerström CG, Ohkawa Y, Imbalzano AN.
Mol Cell Biol. 2010 Jul;30(13):3176-86.
SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.
Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA.
J Cell Physiol. 2010 Jun;223(3):667-78.
Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.
Pratap J, Imbalzano KM, Underwood JM, Cohet N, Gokul K, Akech J, van Wijnen AJ, Stein JL, Imbalzano AN, Nickerson JA, Lian JB, Stein GS.
Cancer Res. 2009 Sep 1;69(17):6807-14.
SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2.
Cruzat F, Henriquez B, Villagra A, Hepp M, Lian JB, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS, Montecino M.
Biochemistry. 2009 Aug 4;48(30):7287-95.
The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells.
Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ.
Oncogene. 2009 Jul 9;28(27):2492-501.
The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression.
Zhou J, Zhang M, Fang H, El-Mounayri O, Rodenberg JM, Imbalzano AN, Herring BP.
Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):921-8.
Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.
Dacwag CS, Bedford MT, Sif S, Imbalzano AN.
Mol Cell Biol. 2009 Apr;29(7):1909-21.
Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture.
Imbalzano KM, Tatarkova I, Imbalzano AN, Nickerson JA.
Cancer Cell Int. 2009 Mar 16;9:7.
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling.
Lai D, Wan M, Wu J, Preston-Hurlburt P, Kushwaha R, Grundström T, Imbalzano AN, Chi T.
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1169-74.
A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype.
Marfella CG, Henninger N, LeBlanc SE, Krishnan N, Garlick DS, Holzman LB, Imbalzano AN.
Kidney Blood Press Res. 2008;31(6):421-32.
p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis.
Coles AH, Marfella CG, Imbalzano AN, Steinman HA, Garlick DS, Gerstein RM, Jones SN.
Cancer Res. 2008 Nov 1;68(21):8705-14.
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.
Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN.
J Cell Biol. 2008 Jun 30;181(7):1055-63.
Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte stress 1 gene promoter.
Ounzain S, Dacwag CS, Samani NJ, Imbalzano AN, Chong NW.
BMC Mol Biol. 2008 May 19;9:50.
Phenotypic transcription factors epigenetically mediate cell growth control.
Ali SA, Zaidi SK, Dacwag CS, Salma N, Young DW, Shakoori AR, Montecino MA, Lian JB, van Wijnen AJ, Imbalzano AN, Stein GS, Stein JL.
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6632-7.
SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling.
Das AV, James J, Bhattacharya S, Imbalzano AN, Antony ML, Hegde G, Zhao X, Mallya K, Ahmad F, Knudsen E, Ahmad I.
J Biol Chem. 2007 Nov 30;282(48):35187-201.
The Chd family of chromatin remodelers.
Marfella CG, Imbalzano AN.
Mutat Res. 2007 May 1;618(1-2):30-40.
Interaction of papillomavirus E2 protein with the Brm chromatin remodeling complex leads to enhanced transcriptional activation.
Kumar RA, Naidu SR, Wang X, Imbalzano AN, Androphy EJ.
J Virol. 2007 Mar;81(5):2213-20.
Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter.
Gutiérrez J, Paredes R, Cruzat F, Hill DA, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Imbalzano AN, Montecino M.
J Biol Chem. 2007 Mar 30;282(13):9445-57.
Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis.
Ohkawa Y, Yoshimura S, Higashi C, Marfella CG, Dacwag CS, Tachibana T, Imbalzano AN.
J Biol Chem. 2007 Mar 2;282(9):6564-70.
Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.
Coles AH, Liang H, Zhu Z, Marfella CG, Kang J, Imbalzano AN, Jones SN.
Cancer Res. 2007 Mar 1;67(5):2054-61.
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.
Young DW, Hassan MQ, Pratap J, Galindo M, Zaidi SK, Lee SH, Yang X, Xie R, Javed A, Underwood JM, Furcinitti P, Imbalzano AN, Penman S, Nickerson JA, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS.
Nature. 2007 Jan 25;445(7126):442-6.
The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling.
Dacwag CS, Ohkawa Y, Pal S, Sif S, Imbalzano AN.
Mol Cell Biol. 2007 Jan;27(1):384-94.
Mutation of the SNF2 family member Chd2 affects mouse development and survival.
Marfella CG, Ohkawa Y, Coles AH, Garlick DS, Jones SN, Imbalzano AN.
J Cell Physiol. 2006 Oct;209(1):162-71. Erratum in: J Cell Physiol. 2007 Aug;212(2):562.
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.
Park JH, Park EJ, Lee HS, Kim SJ, Hur SK, Imbalzano AN, Kwon J.
EMBO J. 2006 Sep 6;25(17):3986-97.
Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis.
Guidi CJ, Mudhasani R, Hoover K, Koff A, Leav I, Imbalzano AN, Jones SN.
Cancer Res. 2006 Aug 15;66(16):8076-82.
Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity.
Villagra A, Cruzat F, Carvallo L, Paredes R, Olate J, van Wijnen AJ, Stein GS, Lian JB, Stein JL, Imbalzano AN, Montecino M.
J Biol Chem. 2006 Aug 11;281(32):22695-706.
The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes.
de la Serna IL, Ohkawa Y, Higashi C, Dutta C, Osias J, Kommajosyula N, Tachibana T, Imbalzano AN.
J Biol Chem. 2006 Jul 21;281(29):20233-41.
The ultrastructure of MCF-10A acini.
Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA.
J Cell Physiol. 2006 Jul;208(1):141-8.
Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers.
de la Serna IL, Ohkawa Y, Imbalzano AN.
Nat Rev Genet. 2006 Jun;7(6):461-73. Review.
HMGN1 is dispensable for myogenesis and adipogenesis.
Hill DA, Imbalzano AN.
Gene. 2006 Apr 12;371(1):59-67. Epub 2006 Jan 31.
Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo.
Salma N, Xiao H, Imbalzano AN.
J Mol Endocrinol. 2006 Feb;36(1):139-51.
Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1.
Ohkawa Y, Marfella CG, Imbalzano AN.
EMBO J. 2006 Feb 8;25(3):490-501. Epub 2006 Jan 19.
Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.
Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, Smale ST.
Genes Dev. 2006 Feb 1;20(3):282-96.
Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes.
Vradii D, Wagner S, Doan DN, Nickerson JA, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Imbalzano AN, Stein GS.
J Cell Physiol. 2006 Jan;206(1):112-8.
Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling.
Hill DA, Peterson CL, Imbalzano AN.
J Biol Chem. 2005 Dec 16;280(50):41777-83.
Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region.
Im H, Grass JA, Johnson KD, Kim SI, Boyer ME, Imbalzano AN, Bieker JJ, Bresnick EH.
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17065-70.
MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex.
de la Serna IL, Ohkawa Y, Berkes CA, Bergstrom DA, Dacwag CS, Tapscott SJ, Imbalzano AN.
Mol Cell Biol. 2005 May;25(10):3997-4009.
Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability.
Imbalzano AN, Jones SN.
Cancer Cell. 2005 Apr;7(4):294-5.
SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation.
Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB.
J Cell Biochem. 2005 Mar 1;94(4):720-30.
Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme.
Hill DA, Chiosea S, Jamaluddin S, Roy K, Fischer AH, Boyd DD, Nickerson JA, Imbalzano AN.
J Cell Sci. 2004 Nov 15;117(Pt 24):5847-54.
Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex.
Biswas D, Imbalzano AN, Eriksson P, Yu Y, Stillman DJ.
Mol Cell Biol. 2004 Sep;24(18):8312-21.
p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci.
Simone C, Forcales SV, Hill DA, Imbalzano AN, Latella L, Puri PL.
Nat Genet. 2004 Jul;36(7):738-43.
Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor.
Salma N, Xiao H, Mueller E, Imbalzano AN.
Mol Cell Biol. 2004 Jun;24(11):4651-63.
Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes.
Doan DN, Veal TM, Yan Z, Wang W, Jones SN, Imbalzano AN.
Oncogene. 2004 Apr 22;23(19):3462-73.
BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.
Hill DA, de la Serna IL, Veal TM, Imbalzano AN.
J Cell Biochem. 2004 Apr 1;91(5):987-98.
Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor.
Guidi CJ, Veal TM, Jones SN, Imbalzano AN.
J Biol Chem. 2004 Feb 6;279(6):4180-5.
Repositioning of muscle-specific genes relative to the periphery of SC-35 domains during skeletal myogenesis.
Moen PT Jr, Johnson CV, Byron M, Shopland LS, de la Serna IL, Imbalzano AN, Lawrence JB.
Mol Biol Cell. 2004 Jan;15(1):197-206.
Functional properties of ATP-dependent chromatin remodeling enzymes.
Imbalzano AN, Xiao H.
Adv Protein Chem. 2004;67:157-79. Review. No abstract available.
Unfolding heterochromatin for replication.
de la Serna IL, Imbalzano AN.
Nat Genet. 2002 Dec;32(4):560-2. No abstract available.
The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture.
Roy K, de la Serna IL, Imbalzano AN.
J Biol Chem. 2002 Sep 13;277(37):33818-24.
Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes.
Horn PJ, Carruthers LM, Logie C, Hill DA, Solomon MJ, Wade PA, Imbalzano AN, Hansen JC, Peterson CL.
Nat Struct Biol. 2002 Apr;9(4):263-7.
MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes.
de la Serna IL, Roy K, Carlson KA, Imbalzano AN.
J Biol Chem. 2001 Nov 2;276(44):41486-91.
Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice.
Guidi CJ, Sands AT, Zambrowicz BP, Turner TK, Demers DA, Webster W, Smith TW, Imbalzano AN, Jones SN.
Mol Cell Biol. 2001 May;21(10):3598-603.
Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.
Sif S, Saurin AJ, Imbalzano AN, Kingston RE.
Genes Dev. 2001 Mar 1;15(5):603-18.
Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.
de la Serna IL, Carlson KA, Imbalzano AN.
Nat Genet. 2001 Feb;27(2):187-90.
Human SWI/SNF nucleosome remodeling activity is partially inhibited by linker histone H1.
Hill DA, Imbalzano AN.
Biochemistry. 2000 Sep 26;39(38):11649-56.
BRG-1 is required for RB-mediated cell cycle arrest.
Strobeck MW, Knudsen KE, Fribourg AF, DeCristofaro MF, Weissman BE, Imbalzano AN, Knudsen ES.
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7748-53.
Functional delineation of three groups of the ATP-dependent family of chromatin remodeling enzymes.
Boyer LA, Logie C, Bonte E, Becker PB, Wade PA, Wolffe AP, Wu C, Imbalzano AN, Peterson CL.
J Biol Chem. 2000 Jun 23;275(25):18864-70.
Phosphoaminoglycosides inhibit SWI2/SNF2 family DNA-dependent molecular motor domains.
Muthuswami R, Mesner LD, Wang D, Hill DA, Imbalzano AN, Hockensmith JW.
Biochemistry. 2000 Apr 18;39(15):4358-65.
Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene.
de La Serna IL, Carlson KA, Hill DA, Guidi CJ, Stephenson RO, Sif S, Kingston RE, Imbalzano AN.
Mol Cell Biol. 2000 Apr;20(8):2839-51.
Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.
Kwon J, Imbalzano AN, Matthews A, Oettinger MA.
Mol Cell. 1998 Dec;2(6):829-39.
SWI/SNF complexes and facilitation of TATA binding protein:nucleosome interactions.
Imbalzano AN.
Methods. 1998 Aug;15(4):303-14.
Energy-dependent chromatin remodelers: complex complexes and their components.
Imbalzano AN.
Crit Rev Eukaryot Gene Expr. 1998;8(3-4):225-55. Review.
Nucleosome disruption by human SWI/SNF is maintained in the absence of continued ATP hydrolysis.
Imbalzano AN, Schnitzler GR, Kingston RE.
J Biol Chem. 1996 Aug 23;271(34):20726-33.
Activator-dependent regulation of transcriptional pausing on nucleosomal templates.
Brown SA, Imbalzano AN, Kingston RE.
Genes Dev. 1996 Jun 15;10(12):1479-90.
Repression and activation by multiprotein complexes that alter chromatin structure.
Kingston RE, Bunker CA, Imbalzano AN.
Genes Dev. 1996 Apr 15;10(8):905-20. Review.
RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling.
Wilson CJ, Chao DM, Imbalzano AN, Schnitzler GR, Kingston RE, Young RA.
Cell. 1996 Jan 26;84(2):235-44.
Facilitated binding of TATA-binding protein to nucleosomal DNA.
Imbalzano AN, Kwon H, Green MR, Kingston RE.
Nature. 1994 Aug 11;370(6489):481-5.
Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex.
Kwon H, Imbalzano AN, Khavari PA, Kingston RE, Green MR.
Nature. 1994 Aug 11;370(6489):477-81.
The role of ICP4 repressor activity in temporal expression of the IE-3 and latency-associated transcript promoters during HSV-1 infection.
Rivera-Gonzalez R, Imbalzano AN, Gu B, Deluca NA.
Virology. 1994 Aug 1;202(2):550-64.
Transcription factor (TF) IIB and TFIIA can independently increase the affinity of the TATA-binding protein for DNA.
Imbalzano AN, Zaret KS, Kingston RE.
J Biol Chem. 1994 Mar 18;269(11):8280-6.
Substitution of a TATA box from a herpes simplex virus late gene in the viral thymidine kinase promoter alters ICP4 inducibility but not temporal expression.
Imbalzano AN, DeLuca NA.
J Virol. 1992 Sep;66(9):5453-63.
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Imbalzano AN, Coen DM, DeLuca NA.
J Virol. 1991 Feb;65(2):565-74.
Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene.
Imbalzano AN, Shepard AA, DeLuca NA.
J Virol. 1990 Jun;64(6):2620-31.
Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4.
Shepard AA, Imbalzano AN, DeLuca NA.
J Virol. 1989 Sep;63(9):3714-28.