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June 11, 2021 - UMass Chan researchers identify potential antiviral compound for COVID-19, flu, other viral infection


F. Humphries            L. Galia

UMass Medical School scientists Katherine A. Fitzgerald, PhD; Fiachra Humphries, PhD (above, left); and Liraz Galia, PhD (above, right), working with the British-based pharmaceutical company GlaxoSmithKline, have identified a novel molecule capable of stimulating the innate immune system against SARS-CoV-2 virus. A trigger for the STING (stimulator of interferon genes) pathway, the compound, diamidobenzimidazole (diABZI-4), protected animal models and human cells in the lab from SARS-CoV-2 infection. Published in Science Immunology, these results show that diABZI-4 has the potential to be an effective antiviral prophylaxis against COVID-19. 

Excerpt above from UMass Med News. Read full story here.