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Fazzio Lab Publications

Primary Fazzio lab publications are in larger font. Authors from the Fazzio lab are shown in bold italics.

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance.

Chibaya L, Murphy KC, DeMarco KD, Gopalan S, Liu H, Parikh CN, Lopez-Diaz Y, Faulkner M, Li J, Morris JP 4th, Ho YJ, Chana SK, Simon J, Luan W, Kulick A, de Stanchina E, Simin K, Zhu LJ, Fazzio TG, Lowe SW, Ruscetti M.

Nat Cancer. 2023 May 4. doi: 10.1038/s43018-023-00553-8.

Macroscopic quorum sensing sustains differentiating embryonic stem cells.

Daneshpour H, van den Bersselaar P, Chao CH, Fazzio TG, Youk H.

Nat Chem Biol. 2023 May. doi: 10.1038/s41589-022-01225-x.

S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress.

Godbole AA, Gopalan S, Nguyen TK, Munden AL, Lui DS, Fanelli MJ, Vo P, Lewis CA, Spinelli JB, Fazzio TG, Walker AK.

Elife. 2023 Feb 9. doi: 10.7554/eLife.79511.

Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1.

Conti MM, Li R, Narváez Ramos MA, Zhu LJ, Fazzio TG, Benanti JA.

Nat Commun. 2023 Jan 19. doi: 10.1038/s41467-023-36035-9.

Multi-CUT&Tag to simultaneously profile multiple chromatin factors.
Gopalan S, Fazzio TG.
STAR Protoc. 2022 Jan 20. doi: 10.1016/j.xpro.2021.101100.

TAF4b transcription networks regulating early oocyte differentiation.
Gura MA, Relovská S, Abt KM, Seymour KA, Wu T, Kaya H, Turner JMA, Fazzio TG, Freiman RN.
Development 2022 Feb 1. doi: 10.1242/dev.200074.

Simultaneous profiling of multiple chromatin proteins in the same cells.
Gopalan S, Wang Y, Harper NW, Garber M, Fazzio TG.
Mol Cell 2021 Nov 18. doi: 10.1016/j.molcel.2021.09.019.

Characterization of R-Loop-Interacting Proteins in Embryonic Stem Cells Reveals Roles in rRNA Processing and Gene Expression.
Wu T, Nance J, Chu F, Fazzio TG.
Mol Cell Proteomics 2021. doi: 10.1016/j.mcpro.2021.100142.

The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper.

Tavera-Montañez C, Hainer SJ, Cangussu D, Gordon SJV, Xiao Y, Reyes-Gutierrez P, Imbalzano AN, Navea JG, Fazzio TG, Padilla-Benavides T.

FASEB J. 2019 Dec. doi: 10.1096/fj.201901606R.

Profiling of Pluripotency Factors in Single Cells and Early Embryos.
Hainer SJ, Bošković A, McCannell KN, Rando OJ, Fazzio TG.
Cell. 2019 April 2. doi: 10.1016/j.cell.2019.03.014.

High-Resolution Chromatin Profiling Using CUT&RUN.
Hainer SJ, Fazzio TG.
Curr Protoc Mol Biol. 2019 Apr. doi: 10.1002/cpmb.85.

NmeCas9 is an intrinsically high-fidelity genome-editing platform.

Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, Fazzio TG, Zhu LJ, Wolfe SA, Sontheimer EJ.

Genome Biol. 2018 Dec 5. doi: 10.1186/s13059-018-1591-1.

TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis.
Acharya D, Nera B, Milstone ZJ, Bourke L, Yoon Y, Rivera-Pérez JA, Trivedi CM, Fazzio TG.
Sci Rep. 2018 Oct 8. doi: 10.1038/s41598-018-33213-4.

Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs.

Wang F, McCannell KN, Bošković A, Zhu X, Shin J, Yu J, Gallant J, Byron M, Lawrence JB, Zhu LJ, Jones SN, Rando OJ, Fazzio TG, Bach I.

Cell Rep. 2017 Dec 26. doi: 10.1016/j.celrep.2017.12.004.

An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5.
Ee LS, McCannell KN, Tang Y, Fernandes N, Hardy WR, Green MR, Chu F, Fazzio TG.
Stem Cell Reports. 2017 Jun 6. doi: 10.1016/j.stemcr.2017.04.020.

KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency.
Acharya D, Hainer SJ, Yoon Y, Wang F, Bach I, Rivera-Pérez JA, Fazzio TG.
Cell Rep. 2017 Apr 25;19(4):671-679. doi: 10.1016/j.celrep.2017.04.001.

DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells.

Hainer SJ, McCannell KN, Yu J, Ee LS, Zhu LJ, Rando OJ, Fazzio TG.
Elife. 2016 Nov 16. doi: 10.7554/eLife.21964.

Regulation of chromatin structure and cell fate by R-loops.
Fazzio TG.
Transcription. 2016 Aug 7. doi: 10.1080/21541264.2016.1198298.

R loops regulate promoter-proximal chromatin architecture and cellular differentiation.
Chen PB, Chen HV, Acharya D, Rando OJ, Fazzio TG.
Nat Struct Mol Biol. 2015 Dec. doi: 10.1038/nsmb.3122.

Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome.
Hainer SJ, Fazzio TG.
Cell Rep. 2015 Oct 6. doi: 10.1016/j.celrep.2015.08.071.

Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF.
Hainer SJ, Gu W, Carone BR, Landry BD, Rando OJ, Mello CC, Fazzio TG.
Genes Dev. 2015 Feb 15. doi: 10.1101/gad.253534.114.

Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo.
Chen PB, Zhu LJ, Hainer SJ, McCannell KN, Fazzio TG.
BMC Genomics. 2014 Dec 15. doi: 10.1186/1471-2164-15-1104.

High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm.
Carone BR, Hung JH, Hainer SJ, Chou MT, Carone DM, Weng Z, Fazzio TG, Rando OJ.
Dev Cell. 2014 Jul 14. doi: 10.1016/j.devcel.2014.05.024.

Hdac6 regulates Tip60-p400 function in stem cells.
Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG.
Elife. 2013 Dec 3;2:e01557. doi: 10.7554/eLife.01557.

NURDs are required for diversity.
Fazzio TG, Rando OJ.
EMBO J. 2012 May 11. doi: 10.1038/emboj.2012.137.

Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
Yildirim O, Li R, Hung JH, Chen PB, Dong X, Ee LS, Weng Z, Rando OJ, Fazzio TG.
Cell. 2011 Dec 23. doi: 10.1016/j.cell.2011.11.054.