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Gang Han

UMassMed Faculty Page


Title: In Vivo Rechargeable Near Infrared Emitting Mesoporous Persistent Luminescence Nanocomposites. UMMS15-20; Patent Pending. 

  • The invention provides methods to produce novel mesoporous persistent luminescece silica nanoparticles that are uniform and homogeneous for optical imaging applications.

Title: A Novel Biological Imaging Probes: Cascade Sensitization of Tri-doped -NaYF4:Nd,Yb,Er(Tm)/NaYF4 Core/Shell Colloidal Nanoparticles with a Biocompatiable 800 nm Excited Upconverting Luminescence. UMMS13-41; Patent Pending. 

  • The invention provides novel upconverting luminescence materials (e.g., UCNPs) and methods that have constitutional excitation engineered to optimize at about 800 nm, which is not only well away from peak absorption of water, but also is ideally situated at a local minimum of water absorption. A unique class of cascade sensitized tri-doped UCNPs with a biocompatiable 800 nm excitable property are disclosed, for example, tri-doped P-NaYF :Nd,Yb,Er(Tm)/NaYF UCNPs, which employ Nd3+ as 800 nm photon sensitizer and Yb3+ as bridging ions, affording strong green or blue upconversion emissions without photobleaching.


  • The invention provides novel biocompatible upconversion nanoparticles (UCNP) comprising a core of cubic nanocrystals (e.g., comprising α-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb). The disclosed nanoparticles lack the toxicity of traditional UCNPs and are synthesized in a single reactor vessel making them more amenable to large-scale production. Further provided are methods of whole body imaging and photochemical methods using the disclosed nanoparticles.


Innovation TopicsDiagnosticsResearch Tools, Imaging, 3D displaysTumor-targeted imaging, Drug delivery vehicleBioluminescence