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  • Noon JB and Aroian RV. (2017) Recombinant subunit vaccines for soil-transmitted helminths. Parasitology 144(10): 1-26. PDF
  • Chen HD, Kao CY, Liu BY, Huang SW, Kuo CJ, Ruan JW, Lin YH, Huang CR, Chen YH, Wang HD, Aroian RV, Chen CS. (2017) HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Autophagy. 2017 Feb;13(2):371-385. PDF
  • Dementiev A, Board J, Sitaram A, Hey T, Kelker MS, Xu X, Hu Y, Vidal-Quist C, Chikwana V, Griffin S, McCaskill D, Wang NX, Hung SC, Chan MK, Lee MM, Hughes J, Wegener A, Aroian RV, Narva KE, Berry C. (2016) The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins. BMC Biol. 2016 Aug 30;14: 71. PDF
  • Durmaz E, Hu Y, Aroian RV, Klaenhammer TR. (2015) Intracellular and extracellular expression of Bacillus thuringiensis crystal protein Cry5B in Lactococcus lactis for use as an anthelminthic. Appl Environ Microbiol. 2015 Dec 18. PDF
  • Wu CC, Hu Y, Miller M, Aroian RV, Sailor MJ. (2015) Protection and Delivery of Anthelmintic Protein Cry5B to Nematodes Using Mesoporous Silicon Particles. ACS Nano 9(6): 6158-67. PDF
  • Sitaram A and Aroian RV. (2015) The Lessons that Caenorhabditis elegans Has Taught Us About the Mechanism of Action of Crystal Proteins. In: Soberon M, Gao Y, Bravo A, editors. Bt Resistance - Characterization and Strategies for GM Crops Expressing Bacillus thuringiensis Toxins. Oxford: CABI. 2015.
  • Schwarz EM, Hu Y, Antoshechkin I, Miller MM, Sternberg PW, Aroian RV. (2015) The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families. Nat Genet Apr 2015;47(4): 416-22. PDF
  • Somvanshi VS, Ellis BL, Hu Y, and Aroian RV. (2014) Nitazoxanide: Nematicidal mode of action and drug combination studies. Mol Biochem Parasitol 193(1): 1-8. PMID: 24412397 PDF
  • Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, and McGillivray SM. (2013) Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis. Infect Immun December 2013, doi: 10.1128/IAI.01614-13. PDF
  • Hu Y, Miller MM, Derman AI, Ellis BL, Monnerat RG, Pogliano J, and Aroian RV. (2013) A Bacillus subtilis strain engineered for treatment of soil-transmitted helminth diseases. Appl Environ Microbiol, 79(18): 5527-32. Link
  • Hu Y, Ellis BL, Yiu YY, Miller MM, Urban JF, Shi LZ and Aroian RV. (2013) An extensive comparison of the effect of anthelmintic classes on diverse nematodes. PLoS ONE, 8(7): e70702. Link
  • Urban JF, Hu Y,  Miller MM, Scheib U, Yiu YY, and Aroian RV. (2013) Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum. PLoS Negl Trop Dis 7(6): e2263. PDF
  • Los FC, Randis TM, Aroian RV, and Ratner AJ. (2013) Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev 2013 Jun;77(2): 173-207. PDF
  • Los FCO, Ha C, and Aroian RV. (2013) Neuronal Goa and CAPS Regulate Behavioral and Immune Responses to Bacterial Pore-forming Toxins. PLoS ONE 8(1): e54528. (C. elegans) Link
  • Hui F, Scheib U, Hu Y, Sommer RJ, Aroian RV, and Ghosh P. (2012) Structure and Glycolipid Binding Properties of the Nematicidal Protein Cry5B. Biochemistry 51(49): 991-9921. PDF
  • Hu Y, Zhan B, Keegan B, Yiu YY, Miller MM, Jones K, and Aroian RV. (2012) Mechanistic and Single-Dose In Vivo Therapeutic Studies of Cry5B Anthelmintic Action against Hookworms. PLoS Negl Trop Dis 6(11): e1900. PDF
  • Hu Y and Aroian RV. (2012) Bacterial pore-forming proteins as anthelmintics. Invert Neurosci 12(1): 37-41. PDF
  • Hu Y and Aroian RV. (2012) Promise of Bacillus thuringiensis Crystal Proteins as Anthelmintics, in Parasitic Helminths: Targets, Screens, Drugs and Vaccines. Wiley-VCH, Weinheim, Germany, Caffrey and Selzer Editors, 267-282. PDF
  • Kho MF, Beller A, Balasubramani V, Hu Y, Hsu W, Nielsen-LeRoux C, McGillivray SM, Nizet V, and Aroian RV. (2011) The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans. PLoS One 6(12): e29122. PDF
  • Kao CY, Los FCO, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, and Aroian RV. (2011) Gobal functional analyses of cellular responses to pore-forming toxins. PLoS Pathog 7(3): e1001314. (C. elegans) PDF
  • Los FCO, Kao CY, Smitham J, McDonald KL, Ha C, Peixoto CA, and Aroian RV. (2011) RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin. Cell Host Microbe 9(2):147-57 (cover). (C. elegans) PDF
  • Hu Y, Platzer EG, Bellier A, and Aroian RV. (2010) Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility. Proc Natl Acad Sci 107(13): 5955-5960. (C. elegans and Heligmosomoides ploygyrusPDF
  • Balla KM, Lugo-Villarino G, Spitsbergen JM, Stachura DL, Hu Y, Bañuelos K, Romo-Fewell O, Aroian RV, and Traver D. (2010) Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood 116(19): 3944-54. PDF
  • Hu Y, Georghiou SB, Kelleher AJ, and Aroian RV. (2010) Bacillus thuringiensis Cry5B Protein Is Highly Efficacious as a Single-Dose Therapy against an Intestinal Roundworm Infection in Mice. PLoS Negl Trop Dis 6t(3): e614. PDF
  • Chen CS, Bellier A, Kao CY, Yang YL, Chen HD, Los FCO, and Aroian RV. (2010) WWP-1 Is a Novel Modulator of the DAF-2 Insulin-Like Signaling Network Involved in Pore-Forming Toxin Cellular Defenses in Caenorhabditis elegans. PLoS ONE 5(3): e9494. PDF
  • Bellier A, Chen CS, Kao CY, Cinar HN, and Aroian RV. (2009) Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. PLoS Pathogens 5(12): e1000689. PDF
  • McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Zhang DX, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V. (2009) ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis. J Innate Immun 1(5): 494-506. PDF
  • Hu YH, Xiao SH, and Aroian RV. (2009) The new anthelmintic tribendimidine is an L-type nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis 3(8): e499. PDF
  • Kao CY, Los FCO, and Aroian RV. (2008) Nervous about immunity: neuronal signals control innate immune system. Nat Immunol 9(12): 1329-30. PDF
  • Bischof LJ, Kao CY, Los FCO, Gonzalez MR, Shen Z, Briggs SP, van der Goot FG, and Aroian RV. (2008) Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathogens 4(10): e1000176. PDF
  • Li XQ, Tan A, Voegtline M, Bekele S, Chen CS, and Aroian RV. (2008) Expression of Cry5B Protein from Bacillus thuringiensis in Plant Roots Confers Resistance to Root-Knot Nematode. Biological Control 47(1): 97-102. PDF 
  • Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, and Aroian RV. (2007) Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. J Biol Chem 282: 3302-3311. PDF
  • Barrows BD, Griffitts JS, Aroian RV. (2007) Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans. J Invertebr Pathol 95(3): 198-200. PDF
  • Li XQ, Wei JZ, Tan A, and Aroian RV. (2007) Resistance to root-knot nematode in tomato roots expressing a nematicidal Bacillus thuringiensis crystal protein. Plant Biotech J 5: 455-464. PDF
  • Aroian R and van der Goot FG. (2007) Pore-forming toxins and cellular non-immune defenses (CNIDs). Curr Opin Microbiol 10(1): 57-61. PDF
  • Barrows BD, Griffitts JS, and Aroian RV. (2006) Caenorhabditis elegans carbohydrates in bacterial toxin resistance. Methods Enzymol. 417: 340-58. PDF
  • Cappello M, Bungiro RD, Harrison LM, Bischof LJ, Griffitts JS, Barrows BD, and Aroian RV. (2006) A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum. Proc Natl Acad Sci 103(41): 15154-15159. PDF
  • Bischof LJ, Huffman DL, and Aroian RV. (2006) Assays for toxicity studies in C. elegans with Bt crystal proteins. Meth Mol Biol 351: 139-154.
  • Griffitts JS and Aroian RV. (2005) Many roads to resistance: how invertebrates adapt to Bt toxins. Bioessays 27(6): 614-24. PDF
  • Griffitts JS, Haslam SM, Yang T, Garczynski SF, Mulloy B, Morris H, Cremer PS, Dell A, Adang MJ, and Aroian RV. (2005) Glycolipids as receptors for Bt crystal toxin. Science 307: 922-925. PDF
  • Huffman DL, Abrami L, Sasik R, Corbeil J, van der Goot FG, and Aroian RV. (2004) Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc Natl Acad Sci, 101: 10995-11000. PDF
  • Huffman DL, Bischof LJ, Griffitts JS, and Aroian RV. (2004) Pore worms: Using Caenorhabditis elegans to study how bacterial toxins interact with their target hosts. Int J Med Microbiol, 293: 599-607. PDF
  • Rappleye CA, Tagawa A, Le Bot N, Ahringer J, and Aroian RV. (2003) Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity. BMC Dev Biol 3: 8. PDF
  • Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Müller R, Brown JR, Hennet T, Esko JD, and Aroian RV. (2003) Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin - host interactions. J Biol Chem, 278: 45594-45602. PDF
  • Wei JZ, Hale K, Carta L, Platzer E, Wong C, Fang SC, and Aroian RV. (2003) Bacillus thuringiensis Crystal proteins that target nematodes. Proc Natl Acad Sci 100: 2760-2765. PDF
  • Rappleye CA, Tagawa A, Lyczak R, Bowerman B, and Aroian RV. (2002) The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Developmental Cell 2(2): 195-206. PDF
  • Griffitts JS, Whitacre JL, Stevens DE, and Aroian RV. (2001) Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme. Science 293: 860-864. PDF
  • Tagawa A, Rappleye C, and Aroian RV. (2001) pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo. Developmental Biology 233: 412-424. PDF
  • Marroquin LD, Elyassnia D, Griffitts JS, Feitelson JS and Aroian RV. (2000) Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Genetics 155: 1693-1699. PDF
  • Rappleye C, Paredez A, Smith C, McDonald K and Aroian RV. (1999) The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans. Genes and Development 13: 2838-2851. PDF