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Biochemistry and Molecular Biotechnology
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HIV-1 Protease Inhibitors
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Research
HIV-1 Protease Inhibitors
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NMR Facility
Lab Members
About Akbar Ali
Lab Members
Publications
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Ali Lab
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Research
HIV-1 Protease Inhibitors
HCV NS3/4A Protease Inhibitors
NMR Facility
Lab Members
About Akbar Ali
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Ali Lab
Publications
Total:
40
results
HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues
Saturday, May 27, 2023
Author(s):
Gordon J Lockbaum,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Desaboini Nageswara Rao,Ean Spielvogel,Sook-Kyung Lee,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
European journal of medicinal chemistry
Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance
Wednesday, March 15, 2023
Author(s):
Ean Spielvogel,Sook-Kyung Lee,Shuntai Zhou,Gordon J Lockbaum,Mina Henes,Amy Sondgeroth,Klajdi Kosovrasti,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer,Ronald Swanstrom
Source:
eLife
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease
Tuesday, November 29, 2022
Author(s):
Jacqueto Zephyr,Desaboini Nageswara Rao,Colby Johnson,Ala M Shaqra,Ellen A Nalivaika,Aria Jordan,Nese Kurt Yilmaz,Akbar Ali,Celia A Schiffer
Source:
Bioorganic chemistry
Phenylsulfamoyl Benzoic Acid Inhibitor of ERAP2 with a Novel Mode of Inhibition
Wednesday, June 29, 2022
Author(s):
Richa Arya,Zachary Maben,Digamber Rane,Akbar Ali,Lawrence J Stern
Source:
ACS chemical biology
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance
Sunday, February 20, 2022
Author(s):
Jacqueto Zephyr,Desaboini Nageswara Rao,Sang V Vo,Mina Henes,Klajdi Kosovrasti,Ashley N Matthew,Adam K Hedger,Jennifer Timm,Elise T Chan,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of molecular biology
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants
Wednesday, August 18, 2021
Author(s):
Desaboini Nageswara Rao,Jacqueto Zephyr,Mina Henes,Elise T Chan,Ashley N Matthew,Adam K Hedger,Hasahn L Conway,Mohsan Saeed,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schi...
Source:
Journal of medicinal chemistry
Inhibiting HTLV-1 Protease: A Viable Antiviral Target
Tuesday, February 23, 2021
Author(s):
Gordon J Lockbaum,Mina Henes,Nathaniel Talledge,Linah N Rusere,Klajdi Kosovrasti,Ellen A Nalivaika,Mohan Somasundaran,Akbar Ali,Louis M Mansky,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188
Thursday, January 28, 2021
Author(s):
Gordon J Lockbaum,Archie C Reyes,Jeong Min Lee,Ronak Tilvawala,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Paul R Thompson,Celia A Schiffer
Source:
Viruses
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond
Thursday, January 07, 2021
Author(s):
Ashley N Matthew,Florian Leidner,Gordon J Lockbaum,Mina Henes,Jacqueto Zephyr,Shurong Hou,Desaboini Nageswara Rao,Jennifer Timm,Linah N Rusere,Debra A Ragland,Janet L Paulsen,Kristina Prachanronarong,...
Source:
Chemical reviews
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere
Friday, July 17, 2020
Author(s):
Linah N Rusere,Gordon J Lockbaum,Mina Henes,Sook-Kyung Lee,Ean Spielvogel,Desaboini Nageswara Rao,Klajdi Kosovrasti,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors
Friday, April 03, 2020
Author(s):
Ashley N Matthew,Jacqueto Zephyr,Desaboini Nageswara Rao,Mina Henes,Wasih Kamran,Klajdi Kosovrasti,Adam K Hedger,Gordon J Lockbaum,Jennifer Timm,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
mBio
Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir
Tuesday, December 24, 2019
Author(s):
Jennifer Timm,Klajdi Kosovrasti,Mina Henes,Florian Leidner,Shurong Hou,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope
Wednesday, August 07, 2019
Author(s):
Linah N Rusere,Gordon J Lockbaum,Sook-Kyung Lee,Mina Henes,Klajdi Kosovrasti,Ean Spielvogel,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease
Friday, December 14, 2018
Author(s):
Gordon J Lockbaum,Florian Leidner,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Gily S Nachum,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS infectious diseases
Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease
Tuesday, August 28, 2018
Author(s):
Ashley N Matthew,Florian Leidner,Alicia Newton,Christos J Petropoulos,Wei Huang,Akbar Ali,Nese KurtYilmaz,Celia A Schiffer
Source:
Structure (London, England : 1993)
Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants
Tuesday, July 24, 2018
Author(s):
Linah N Rusere,Ashley N Matthew,Gordon J Lockbaum,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
ACS medicinal chemistry letters
Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants
Friday, June 09, 2017
Author(s):
Ashley N Matthew,Jacqueto Zephyr,Caitlin J Hill,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt-Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side
Friday, March 17, 2017
Author(s):
Kuan-Hung Lin,Akbar Ali,Linah Rusere,Djade I Soumana,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of virology
Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease
Friday, August 12, 2016
Author(s):
Djadé I Soumana,Nese Kurt Yilmaz,Akbar Ali,Kristina L Prachanronarong,Celia A Schiffer
Source:
Journal of the American Chemical Society
P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates
Wednesday, January 06, 2016
Author(s):
Miriam Sansó,Rebecca S Levin,Jesse J Lipp,Vivien Ya-Fan Wang,Ann Katrin Greifenberg,Elizabeth M Quezada,Akbar Ali,Animesh Ghosh,Stéphane Larochelle,Tariq M Rana,Matthias Geyer,Liang Tong,Kevan M Shoka...
Source:
Genes & development
Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172
Sunday, December 20, 2015
Author(s):
Djadé I Soumana,Nese Kurt Yilmaz,Kristina L Prachanronarong,Cihan Aydin,Akbar Ali,Celia A Schiffer
Source:
ACS chemical biology
Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy
Tuesday, May 12, 2015
Author(s):
Jean Ndjomou,M Josie Corby,Noreena L Sweeney,Alicia M Hanson,Cihan Aydin,Akbar Ali,Celia A Schiffer,Kelin Li,Kevin J Frankowski,Frank J Schoenen,David N Frick
Source:
ACS chemical biology
Structural analysis of asunaprevir resistance in HCV NS3/4A protease
Tuesday, September 23, 2014
Author(s):
Djadé I Soumana,Akbar Ali,Celia A Schiffer
Source:
ACS chemical biology
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance
Tuesday, September 10, 2013
Author(s):
Madhavi N L Nalam,Akbar Ali,G S Kiran Kumar Reddy,Hong Cao,Saima G Anjum,Michael D Altman,Nese Kurt Yilmaz,Bruce Tidor,Tariq M Rana,Celia A Schiffer
Source:
Chemistry & biology
Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis
Friday, August 02, 2013
Author(s):
Ahmed Fazly,Charu Jain,Amie C Dehner,Luca Issi,Elizabeth A Lilly,Akbar Ali,Hong Cao,Paul L Fidel,Reeta P Rao,Paul D Kaufman
Source:
Proceedings of the National Academy of Sciences of the United States of America
Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance
Friday, April 19, 2013
Author(s):
Akbar Ali,Cihan Aydin,Reinhold Gildemeister,Keith P Romano,Hong Cao,Ayşegül Ozen,Djade Soumana,Alicia Newton,Christos J Petropoulos,Wei Huang,Celia A Schiffer
Source:
ACS chemical biology
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors
Thursday, August 23, 2012
Author(s):
Keith P Romano,Akbar Ali,Cihan Aydin,Djade Soumana,Ayşegül Ozen,Laura M Deveau,Casey Silver,Hong Cao,Alicia Newton,Christos J Petropoulos,Wei Huang,Celia A Schiffer
Source:
PLoS pathogens
Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication
Saturday, May 05, 2012
Author(s):
Akbar Ali,Jinhua Wang,Robin S Nathans,Hong Cao,Natalia Sharova,Mario Stevenson,Tariq M Rana
Source:
ChemMedChem
Molecular Basis for Drug Resistance in HIV-1 Protease
Friday, October 14, 2011
Author(s):
Akbar Ali,Rajintha M Bandaranayake,Yufeng Cai,Nancy M King,Madhavi Kolli,Seema Mittal,Jennifer F Murzycki,Madhavi N L Nalam,Ellen A Nalivaika,Ayşegül Özen,Moses M Prabu-Jeyabalan,Kelly Thayer,Celia A ...
Source:
Viruses
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding
Friday, November 19, 2010
Author(s):
Keith P Romano,Akbar Ali,William E Royer,Celia A Schiffer
Source:
Proceedings of the National Academy of Sciences of the United States of America
Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones
Thursday, October 21, 2010
Author(s):
Akbar Ali,G S Kiran Kumar Reddy,Madhavi N L Nalam,Saima Ghafoor Anjum,Hong Cao,Celia A Schiffer,Tariq M Rana
Source:
Journal of medicinal chemistry
P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes
Thursday, June 17, 2010
Author(s):
Siobhan K O'Brien,Hong Cao,Robin Nathans,Akbar Ali,Tariq M Rana
Source:
The Journal of biological chemistry
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance
Friday, March 19, 2010
Author(s):
Madhavi N L Nalam,Akbar Ali,Michael D Altman,G S Kiran Kumar Reddy,Sripriya Chellappan,Visvaldas Kairys,Aysegül Ozen,Hong Cao,Michael K Gilson,Bruce Tidor,Tariq M Rana,Celia A Schiffer
Source:
Journal of virology
Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication
Thursday, July 16, 2009
Author(s):
Akbar Ali,Animesh Ghosh,Robin S Nathans,Natalia Sharova,Siobhan O'Brien,Hong Cao,Mario Stevenson,Tariq M Rana
Source:
Chembiochem : a European journal of chemical biology
Small-molecule inhibition of HIV-1 Vif
Tuesday, September 23, 2008
Author(s):
Robin Nathans,Hong Cao,Natalia Sharova,Akbar Ali,Mark Sharkey,Ruzena Stranska,Mario Stevenson,Tariq M Rana
Source:
Nature biotechnology
Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres
Sunday, August 19, 2007
Author(s):
G S Kiran Kumar Reddy,Akbar Ali,Madhavi N L Nalam,Saima Ghafoor Anjum,Hong Cao,Robin S Nathans,Celia A Schiffer,Tariq M Rana
Source:
Journal of medicinal chemistry
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands
Friday, December 08, 2006
Author(s):
Akbar Ali,G S Kiran Kumar Reddy,Hong Cao,Saima Ghafoor Anjum,Madhavi N L Nalam,Celia A Schiffer,Tariq M Rana
Source:
Journal of medicinal chemistry
Dissecting RNA-interference pathway with small molecules
Saturday, June 25, 2005
Author(s):
Ya-Lin Chiu,Chimmanamada U Dinesh,Chia-ying Chu,Akbar Ali,Kirk M Brown,Hong Cao,Tariq M Rana
Source:
Chemistry & biology
Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells
Wednesday, August 25, 2004
Author(s):
Ya-Lin Chiu,Akbar Ali,Chia-Ying Chu,Hong Cao,Tariq M Rana
Source:
Chemistry & biology
Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication
Tuesday, July 15, 2003
Author(s):
Seongwoo Hwang,Natarajan Tamilarasu,Karen Kibler,Hong Cao,Akbar Ali,Yueh-Hsin Ping,Kuan-Teh Jeang,Tariq M Rana
Source:
The Journal of biological chemistry
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