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Research
HIV-1 Protease Inhibitors
HCV NS3/4A Protease Inhibitors
APOBEC3 Inhibitors
NMR Facility
Publications
The Lab
The PI
Lab Members
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Ali Lab
Home
Research
HIV-1 Protease Inhibitors
HCV NS3/4A Protease Inhibitors
APOBEC3 Inhibitors
NMR Facility
Publications
The Lab
The PI
Lab Members
Contact
Our most recent publications:
Total:
displaying 10 out of
17
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Inhibiting HTLV-1 Protease: A Viable Antiviral Target
Tuesday, February 23, 2021
Author(s):
Gordon J Lockbaum,Mina Henes,Nathaniel Talledge,Linah N Rusere,Klajdi Kosovrasti,Ellen A Nalivaika,Mohan Somasundaran,Akbar Ali,Louis M Mansky,Nese Kurt Yilmaz,Celia A Schiffer
Source:
ACS chemical biology
Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188
Thursday, January 28, 2021
Author(s):
Gordon J Lockbaum,Archie C Reyes,Jeong Min Lee,Ronak Tilvawala,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Paul R Thompson,Celia A Schiffer
Source:
Viruses
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond
Thursday, January 07, 2021
Author(s):
Ashley N Matthew,Florian Leidner,Gordon J Lockbaum,Mina Henes,Jacqueto Zephyr,Shurong Hou,Desaboini Nageswara Rao,Jennifer Timm,Linah N Rusere,Debra A Ragland,Janet L Paulsen,Kristina Prachanronarong,Djade I Soumana,Ellen A Nalivaika,Nese Kurt Yilmaz,Akbar Ali,Celia A Schiffer
Source:
Chemical reviews
Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease
Tuesday, August 28, 2018
Author(s):
Ashley N Matthew,Florian Leidner,Alicia Newton,Christos J Petropoulos,Wei Huang,Akbar Ali,Nese KurtYilmaz,Celia A Schiffer
Source:
Structure (London, England : 1993)
Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants
Tuesday, July 24, 2018
Author(s):
Linah N Rusere,Ashley N Matthew,Gordon J Lockbaum,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
Source:
ACS medicinal chemistry letters
Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants
Friday, June 09, 2017
Author(s):
Ashley N Matthew,Jacqueto Zephyr,Caitlin J Hill,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt-Yilmaz,Celia A Schiffer,Akbar Ali
Source:
Journal of medicinal chemistry
Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side
Friday, March 17, 2017
Author(s):
Kuan-Hung Lin,Akbar Ali,Linah Rusere,Djade I Soumana,Nese Kurt Yilmaz,Celia A Schiffer
Source:
Journal of virology
Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease
Friday, August 12, 2016
Author(s):
Djadé I Soumana,Nese Kurt Yilmaz,Akbar Ali,Kristina L Prachanronarong,Celia A Schiffer
Source:
Journal of the American Chemical Society
P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates
Wednesday, January 06, 2016
Author(s):
Miriam Sansó,Rebecca S Levin,Jesse J Lipp,Vivien Ya-Fan Wang,Ann Katrin Greifenberg,Elizabeth M Quezada,Akbar Ali,Animesh Ghosh,Stéphane Larochelle,Tariq M Rana,Matthias Geyer,Liang Tong,Kevan M Shokat,Robert P Fisher
Source:
Genes & development
Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172
Sunday, December 20, 2015
Author(s):
Djadé I Soumana,Nese Kurt Yilmaz,Kristina L Prachanronarong,Cihan Aydin,Akbar Ali,Celia A Schiffer
Source:
ACS chemical biology
Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy
Tuesday, May 12, 2015
Author(s):
Jean Ndjomou,M Josie Corby,Noreena L Sweeney,Alicia M Hanson,Cihan Aydin,Akbar Ali,Celia A Schiffer,Kelin Li,Kevin J Frankowski,Frank J Schoenen,David N Frick
Source:
ACS chemical biology
Structural analysis of asunaprevir resistance in HCV NS3/4A protease
Tuesday, September 23, 2014
Author(s):
Djadé I Soumana,Akbar Ali,Celia A Schiffer
Source:
ACS chemical biology
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance
Tuesday, September 10, 2013
Author(s):
Madhavi N L Nalam,Akbar Ali,G S Kiran Kumar Reddy,Hong Cao,Saima G Anjum,Michael D Altman,Nese Kurt Yilmaz,Bruce Tidor,Tariq M Rana,Celia A Schiffer
Source:
Chemistry & biology
Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis
Friday, August 02, 2013
Author(s):
Ahmed Fazly,Charu Jain,Amie C Dehner,Luca Issi,Elizabeth A Lilly,Akbar Ali,Hong Cao,Paul L Fidel,Reeta P Rao,Paul D Kaufman
Source:
Proceedings of the National Academy of Sciences of the United States of America
Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance
Friday, April 19, 2013
Author(s):
Akbar Ali,Cihan Aydin,Reinhold Gildemeister,Keith P Romano,Hong Cao,Ayşegül Ozen,Djade Soumana,Alicia Newton,Christos J Petropoulos,Wei Huang,Celia A Schiffer
Source:
ACS chemical biology
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding
Friday, November 19, 2010
Author(s):
Keith P Romano,Akbar Ali,William E Royer,Celia A Schiffer
Source:
Proceedings of the National Academy of Sciences of the United States of America
Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones
Thursday, October 21, 2010
Author(s):
Akbar Ali,G S Kiran Kumar Reddy,Madhavi N L Nalam,Saima Ghafoor Anjum,Hong Cao,Celia A Schiffer,Tariq M Rana
Source:
Journal of medicinal chemistry
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