Site Menu
Search Close Search
Search Close Search
Page Menu

Publications

Yingleong Rigel Chan
Publication List

Elaine Lim Publications

There are no results for this RSS feed at this time.

Total: 15 results

  • Outcomes of a prospective cohort study of PREoperative therapy and supportive care in early & locally advanced breast cancers-PreSCella study

    Wednesday, January 28, 2026
    Author(s): Han Yi Lee,Whee Sze Ong,Jasmine Yun Ting Tan,Jun Ma,Zewen Zhang,Si Ying Tan,Grace Meijuan Yang,Irene Teo,Wei Lin Goh,Mabel May Leng Tan,Yoon Sim Yap,Jack Junjie Chan,Ryan Shea Ying Cong Tan,Wu Meng Tan,Elaine Lim,Huren Sivaraj,Sok Yuen Beh,Lay Tin Soh,Wen Yee Chay,Rebecca Dent,Ravindran Kanesvaran,Mabel Wong,Benita Kiat Tee Tan,Fuh Yong Wong,Kiak Mien Veronique Tan,Tira J Tan
    Source: NPJ breast cancer
    The PREoperative therapy and Supportive Care in EarLy and Locally Advanced breast cancers (PreSCella) study, conducted within Singapore's SingHealth network, explored how quality of life (QOL) and supportive care needs change over the course of neoadjuvant therapy (NAT) for breast cancer. Using a longitudinal design, data were collected at three points: before NAT (T1), within two months post-surgery (T2), and at the one-year follow-up (T3). Of 241 patients enrolled, 235 were analysed. Overall...

  • Ectopy-triggering ganglionated plexus ablation is feasible as a solo strategy for persistent and long-standing persistent atrial fibrillation treatment

    Sunday, August 31, 2025
    Author(s): Clare Coyle,Jamie Kay,Daniel Keene,Ji-Jian Chow,Louisa Malcolme-Lawes,Elaine Lim,Michael Fudge,Ian J Wright,Ivin Jose,Michael Koa-Wing,Fu Siong Ng,Norman A Qureshi,Zachary I Whinnett,Nicholas S Peters,Phang Boon Lim,Nicholas W F Linton,Prapa Kanagaratnam
    Source: Heart rhythm
    CONCLUSION: ET-GP mapping and ablation, as a solo ablation strategy, are feasible in persistent AF and can prevent AF recurrence at 1 year.

  • Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

    Tuesday, June 10, 2025
    Author(s): Songlei Liu,Li Li,Fan Zhang,Mariana Garcia-Corral,Katharina Meyer,Patrick R J Fortuna,Björn van Sambeek,Evan Appleton,Alex H M Ng,Parastoo Khoshakhlagh,Yuancheng Ryan Lu,James Cameron,Ricardo N Ramirez,Yuting Chen,Chun-Ting Wu,Jeremy Y Huang,Yuqi Tan,George Chao,John Aach,Elaine T Lim,Jenny M Tam,Soumya Raychaudhuri,George M Church
    Source: Nature communications
    Differentiation of induced pluripotent stem cells (iPSCs) into specialized cell types is essential for uncovering cell-type specific molecular mechanisms and interrogating cellular function. Transcription factor screens have enabled efficient production of a few cell types; however, engineering cell types that require complex transcription factor combinations remains challenging. Here, we report an iterative, high-throughput single-cell transcription factor screening method that enables the...

  • Cell Migration in Endometriosis Responds to Omentum-Derived Molecular Cues Similar to Ovarian Cancer

    Thursday, March 13, 2025
    Author(s): Kah Yee Goh,Su Chin Tham,Terence You De Cheng,Ravichandran Nadarajah,Ronald Chin Hong Goh,Shing Lih Wong,Tew Hong Ho,Ghee Kheng Chew,Andy Wei Keat Tan,Hemashree Rajesh,Hong Liang Chua,Tze Tein Yong,Su Ling Yu,Jia Min Kang,Kah Weng Lau,Amos Zhi En Tay,Sangeeta Mantoo,Inny Busmanis,Sung Hock Chew,Timothy Yong Kuei Lim,Wai Loong Wong,Qiu Ju Ng,Junjie Wang,Sun Kuie Tay,Chit Fang Cheok,Darren Wan-Teck Lim,Elaine Hsuen Lim
    Source: International journal of molecular sciences
    Endometriosis is common and poses significant morbidity of lasting impact to young, pre-menopausal women, while ovarian cancer is a lethal gynecologic condition. Both conditions need better treatment. The human omentum is an apron of adipose tissue in the abdominopelvic cavity, the same space in which endometriosis and ovarian cancer manifest. We aim to determine molecular cues emitted by the omentum that aid the trans-coelomic spread of endometriosis and ovarian cancer in the...

  • Alzheimer's disease-associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain

    Thursday, December 19, 2024
    Author(s): Benjamin P Readhead,Diego F Mastroeni,Qi Wang,Maria A Sierra,Camila de Ávila,Tajudeen O Jimoh,Jean-Vianney Haure-Mirande,Kristina E Atanasoff,Jennifer Nolz,Crystal Suazo,Nathaniel J Barton,Adrian R Orszulak,Samantha M Chigas,Khanh Tran,Anne Mirza,Krista Ryon,Jacqueline Proszynski,Deena Najjar,Joel T Dudley,Sean T H Liu,Sam Gandy,Michelle E Ehrlich,Eric Alsop,Jerry Antone,Rebecca Reiman,Cory Funk,Rebecca L Best,Michael Jhatro,Kathy Kamath,John Shon,Timothy F Kowalik,David A Bennett,Winnie S Liang,Geidy E Serrano,Thomas G Beach,Kendall Van Keuren-Jensen,Christopher E Mason,Yingleong Chan,Elaine T Lim,Domenico Tortorella,Eric M Reiman
    Source: Alzheimer's & dementia : the journal of the Alzheimer's Association
    INTRODUCTION: While there may be microbial contributions to Alzheimer's disease (AD), findings have been inconclusive. We recently reported an AD-associated CD83(+) microglia subtype associated with increased immunoglobulin G4 (IgG4) in the transverse colon (TC).

  • Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases

    Tuesday, December 17, 2024
    Author(s): Jonathan Sundstrom,Emma Vanderleeden,Nathaniel J Barton,Sambra D Redick,Pepper Dawes,Liam F Murray,Meagan N Olson,Khanh Tran,Samantha M Chigas,Adrian R Orszulak,George M Church,Benjamin Readhead,Hyung Suk Oh,David M Harlan,David M Knipe,Jennifer P Wang,Yingleong Chan,Elaine T Lim
    Source: Cells
    Viral infections leading to inflammation have been implicated in several common diseases, such as Alzheimer's disease (AD) and type 1 diabetes (T1D). Of note, herpes simplex virus 1 (HSV-1) has been reported to be associated with AD. We sought to identify the transcriptomic changes due to HSV-1 infection and anti-viral drug (acyclovir, ACV) treatment of HSV-1 infection in dissociated cells from human cerebral organoids (dcOrgs) versus stem cell-derived pancreatic islets (sc-islets) to gain...

  • Long-term outcomes of ganglionated plexus ablation as sole therapy for paroxysmal atrial fibrillation

    Sunday, December 15, 2024
    Author(s): Jamie Kay,Min-Young Kim,Clare Coyle,David R Tomlinson,Louisa Malcolme-Lawes,Elaine Lim,Michael Fudge,Ian J Wright,Michael Koa-Wing,Fu Siong Ng,Norman A Qureshi,Zachary I Whinnett,Nicholas S Peters,Gurpreet Dhillon,Ross J Hunter,Phang Boon Lim,Nicholas W F Linton,Prapa Kanagaratnam
    Source: Heart rhythm
    No abstract

  • Cost-minimization analysis comparing subcutaneous trastuzumab at home with intravenous trastuzumab for HER2-positive breast cancer in Singapore

    Tuesday, November 12, 2024
    Author(s): Yanting Ouyang,Han Yi Lee,Fun Loon Leong,Han Jieh Tey,Vivianne Shih,Elaine Hsuen Lim,Nicholas Graves
    Source: Therapeutic advances in medical oncology
    CONCLUSION: Treatment of breast cancer with Homecare SC Herceptin is a cost-saving option compared to IV Herceptin.

  • Efficacy and safety of sacituzumab govitecan Trop-2-targeted antibody-drug conjugate in solid tumors and UGT1A1*28 polymorphism: a systematic review and meta-analysis

    Monday, November 11, 2024
    Author(s): Rehena Sultana,Sylvia Chen,Elaine Hsuen Lim,Rebecca Dent,Balram Chowbay
    Source: BJC reports
    CONCLUSION: Our systematic review and meta-analysis confirmed that SG confers good clinical activity in certain solid tumor types and was tolerable with minimal adverse events. The potential utility of UGT1A1*28 genotyping in predicting clinical response and outcomes could not be determined due to the limited number of studies with available UGT1A1 genotype data.

  • Deciphering tumour microenvironment and elucidating the origin of cancer cells in ovarian clear cell carcinoma

    Friday, August 16, 2024
    Author(s): Uma S Kamaraj,Pradeep Gautam,Terence Cheng,Tham Su Chin,Sun Kuie Tay,Tew Hong Ho,Ravichandran Nadarajah,Ronald Chin Hong Goh,Shing Lih Wong,Sangeeta Mantoo,Inny Busmanis,Hu Li,Minh Tn Le,Qi-Jing Li,Elaine Hsuen Lim,Yuin-Han Loh
    Source: bioRxiv : the preprint server for biology
    Ovarian clear cell carcinoma (CCC) has an East Asian preponderance. It is associated with endometriosis, a benign condition where endometrial (inner lining of the uterus) tissue is found outside the uterus and on the peritoneal surface, in the abdominal or pelvic space. CCC is relatively more resistant to conventional chemotherapy compared to other ovarian cancer subtypes and is associated with a poorer prognosis. In this study, we recruited and obtained tumour tissues from seven patients across...

  • Mapping recurrent mosaic copy number variation in human neurons

    Friday, May 17, 2024
    Author(s): Chen Sun,Kunal Kathuria,Sarah B Emery,ByungJun Kim,Ian E Burbulis,Joo Heon Shin,Brain Somatic Mosaicism Network,Daniel R Weinberger,John V Moran,Jeffrey M Kidd,Ryan E Mills,Michael J McConnell
    Source: Nature communications
    When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during neurotypical brain development, but neurons are almost never the origin of brain cancers. Instead, somatic mutations in neurons can bring about neurodevelopmental disorders, and contribute to the polygenic landscape of neuropsychiatric and neurodegenerative disease. A subset of human...

  • Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study

    Thursday, March 28, 2024
    Author(s): Patrick Henry Sebastian Sitjar,Si Ying Tan,Mabel Wong,Jingmei Li,Rufaihah Binte Abdul Jalil,Huizhen Aw,Elaine Hsuen Lim,Jorming Goh
    Source: GeroScience
    Breast cancer (BC) is the most prominent cancer amongst women, but fortunately, early diagnosis and advances in multimodality treatments have improved patient survivability. Cancer survivors, however, experience increased biological ageing which may accelerate other co-morbidities. Exercise intervention is a promising clinical adjuvant approach to improve BC patients' physiological function, recovery from treatment, and quality of life. However, the effects of combined aerobic and strength...

  • Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

    Thursday, March 21, 2024
    Author(s): Salome Funes,Jonathan Jung,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,None Shankaracharya,Matthew Unger,Karly Stallworth,Debra Cameron,Melissa S Rotunno,Pepper Dawes,Megan Fowler-Magaw,Pamela J Keagle,Justin A McDonough,Sivakumar Boopathy,Miguel Sena-Esteves,Jeffrey A Nickerson,Cathleen Lutz,William C Skarnes,Elaine T Lim,Dorothy P Schafer,Francesca Massi,John E Landers,Daryl A Bosco
    Source: Nature communications
    Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the intrinsic properties of microglia, we studied microglia-like cells derived from human induced pluripotent stem cells (iPSCs), termed iMGs, harboring mutations in profilin-1 (PFN1) that are causative for amyotrophic lateral sclerosis (ALS). ALS-PFN1 iMGs...

  • Cost-effectiveness analysis of add-on pertuzumab to trastuzumab biosimilar and chemotherapy as neoadjuvant treatment for human epidermal growth receptor 2-positive early breast cancer patients in Singapore

    Tuesday, January 30, 2024
    Author(s): Elaine Hsuen Lim,Andrew Lim,Jasmeet Singh Khara,John Cheong,Jek Fong,Sivabalan Sivanesan,Matt Griffiths,Emma New,Soo Chin Lee
    Source: Expert review of pharmacoeconomics & outcomes research
    CONCLUSIONS: This model demonstrated that the long-term clinical impact of early pertuzumab use, particularly the avoidance of metastatic disease and thus avoidance of higher costs and mortality rates, make neoadjuvant pertuzumab a cost-effective option in the management of patients with HER2+ breast cancer in Singapore.

  • Mutational spectrum and phenotypic variability of Duchenne muscular dystrophy and related disorders in a Bangladeshi population

    Wednesday, December 06, 2023
    Author(s): Shaoli Sarker,Tamannyat Binte Eshaque,Anjana Soorajkumar,Nasna Nassir,Binte Zehra,Shayla Imam Kanta,Md Atikur Rahaman,Amirul Islam,Shimu Akter,Mohammad Kawsar Ali,Rabeya Akter Mim,K M Furkan Uddin,Mohammod Shah Jahan Chowdhury,Nusrat Shams,Md Abdul Baqui,Elaine T Lim,Hosneara Akter,Marc Woodbury-Smith,Mohammed Uddin
    Source: Scientific reports
    Duchenne muscular dystrophy (DMD) is a severe rare neuromuscular disorder caused by mutations in the X-linked dystrophin gene. Several mutations have been identified, yet the full mutational spectrum, and their phenotypic consequences, will require genotyping across different populations. To this end, we undertook the first detailed genotype and phenotype characterization of DMD in the Bangladeshi population. We investigated the rare mutational and phenotypic spectrum of the DMD gene in 36...